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Oramec (Ivermectin)
Oramec (Ivermectin)
Oramec (Ivermectin)
Oramec (Ivermectin)

Oramec (Ivermectin)

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Oramec drench is an ivermectin based wormer for sheep. Oramec is used for the treatment and control of gastro-intestinal worms, lungworms and nasal bots.

Active Ingredient: Ivermectin

Target Species: Sheep

Administration Method: Oral drench

Treats and Controls: Gastro-intestinal worms, lungworms, nasal bots

Withdrawal Time: 6 days for sheep intended for meat and offal. Not permitted for use on sheep producing milk for human consumption

Dosage for sheep: 2.5 ml per 10 kg of bodyweight.

Body Weight Dose Volume Number of worm doses per pack
1 Litre 2.5 Litre 5 Litre
10kg 2.5 ml 200 1000 2000
20kg 5 ml 400 500 1000
30kg 7.5 ml 133 333 667
40kg 10 ml 100 250 500
50kg 12.5 ml 80 200 400
60kg 15 ml 67 167 333
70kg 17.5 ml 57 143 286

Always read the label and all enclosed information for Oramec Oral Suspension before administering to animals!

 

Key Features of Oramec

  • An ivermectin based wormer for sheep. 
  • Used for the treatment and control of gastro-intestinal worms, lungworms and nasal bots.
  • Withdrawel period of 6 days for sheep intended for meat and offal. 
  • Not permitted for use on sheep producing milk for human consumption

Commonly asked questions about Oramec Drench

Q. Will Oramec  kill worms that are resistant to control by white drenches?

A. Yes. Oramec is routinely used in wormer rotation programmes. Also, it is often used to treat sheep that are brought in from market and neighbouring farms where the worming history is either not known or may be in doubt. It makes sense to treat all sheep with Oramec and keep them isolated, preferably on hard standing, for 48 hours before mixing them with the main flock.

Q. Will Oramec control inhibited time-bomb worms and help prevent the spring rise?

A. Yes. Treat the ewes just before you house the sheep or just prior to lambing. This will kill the dormant worms in the sheep that would emerge in the spring and contaminate pasture at the time when lambs are beginning to graze.

How sheep contract worms:

 

​This product is only licensed for sale within the Republic of Ireland

 

Click here to Download Data Sheet

 

Summary of Product Characteristics

1 NAME OF THE VETERINARY MEDICINAL PRODUCT
ORAMEC Drench for Sheep 0.8 mg/ml

2 QUALITATIVE AND QUANTITATIVE COMPOSITION
Active substance
Ivermectin 0.8 mg/ml


Excipients
Benzyl Alcohol 31.0 mg/ml

For a full list of excipients, see section 6.1

3 PHARMACEUTICAL FORM
Oral solution.

4 CLINICAL PARTICULARS
4.1 Target Species
Sheep.

4.2 Indications for use, specifying the target species
ORAMEC Drench for Sheep is highly effective for the treatment and control of mixed infections with the following
gastrointestinal roundworms (including benzimidazole-resistant strains of Haemonchus contortus, Ostertagia circumcincta and levamisole-resistant strains of H. contortus, O. circumcincta and T. colubriformis):

Gastrointestinal roundworms (adult and fourth larval stage)
Haemonchus contortus*
Ostertagia circumcincta*
Trichostrongylus spp.
Cooperia spp.
Nematodirus spp.
Including N. battus
Strongyloides papillosus
Oesophagostomum spp.
Chabertia ovina

Lungworms (adult and fourth larval stage)
Dictyocaulus filaria

Nasal bot (all larval stages)
Oestrus ovis
* including benzimidazole resistant strains.

4.3 Contraindications
Do not use in animals with known hypersensitivity to the active ingredient.

4.4 Special warnings for each target species
Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately
result in ineffective therapy:
• Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
• Underdosing which may be due to underestimation of bodyweight, misadministration of the product, or lack of calibration of the dosing device.
Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the tests strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.

4.5 Special precautions for use
Special precautions for use in animals:
No special precautions are required.

Special precautions to be taken by the person administering the veterinary medicinal product to animals:
Wash hands after use.
Do not smoke or eat while handling the product.
Avoid contact with skin and eyes. If this occurs, rinse affected area immediately with water.

4.6 Adverse reactions (frequency and seriousness)
ORAMEC Drench for Sheep is readily accepted by the animal. Some sheep may cough immediately after treatment.
This passing response is of no consequence.

4.7 Use during pregnancy, lactation or lay
ORAMEC Drench for Sheep can be administered to ewes at any stage of pregnancy or lactation provided that the milk is not used for human consumption.
ORAMEC Drench for Sheep will not affect the fertility of breeding ewes and rams and can be given to all ages of animals including young lambs.

4.8 Interaction with other medicinal products and other forms of interaction
ORAMEC Drench for Sheep may be used concurrently with clostridial vaccine without any adverse effects. Adequate
vaccination of sheep against clostridial infections is strongly recommended.

4.9 Amounts to be administered and administration route
Oral administration with a dosing gun of 2.5 ml per 10 kg bodyweight (corresponding to the recommended dose rate of 0.2 mg ivermectin per kg bodyweight).
To ensure administration of a correct dose, bodyweight should be determined as accurately as possible.
If animals are to be treated collectively rather than individually, they should be grouped according to their bodyweight and dosed accordingly, in order to avoid under- or overdosing.
Use properly calibrated dosing equipment.

ORAMEC Drench for Sheep has demonstrated a wide safety margin at the recommended dose level.
ORAMEC Drench for Sheep may be used in sheep of all ages.

4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
At doses up to 4 mg ivermectin per kg administered by stomach tube (20x the recommended dose level) undesirable
toxic reactions occurred. Acute symptoms (ataxia, staggering gait, incoordination, depression) were observed at the
dose rate of 8 mg/kg (40x the recommended dose level) during a study carried out on 4 animals. Twenty-four hours
later, the animals showed only mild incoordination and depression.
Three days post dose all the animals were nearly normal. It is possible that the signs of toxaemia were due to the
propylene glycol.
No antidote has been identified; however, symptomatic treatment may be beneficial.

4.11 Withdrawal Period(s)
Animals intended for human consumption must not be slaughtered during treatment.
Animals intended for human consumption may only be slaughtered from 6 days after the last treatment.
Do not use in lactating sheep producing milk for human consumption.
Sheep must not be treated within 60 days prior to the commencement of lactation, if milk is to be used for human
consumption.

5 PHARMACOLOGICAL or IMMUNOLOGICAL PROPERTIES
Phamacotherapeutic group:
Anthelmintics, ivermectin.

ATCvet code:
QP54AA01

5.1 Pharmacodynamic properties
Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action.
Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells.
This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite.
Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gammaaminobutyric acid (GABA).
The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated
chloride channels, the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels and they do not readily cross the blood-brain barrier.

5.2 Pharmacokinetic properties
Maximum plasma concentration:

The maximum plasma concentration is reached in 6 hours after oral administration and ranges from 12 to 34 ng/ml at
the dose rate of 0.3 mg ivermectin per kg bodyweight. This concentration gradually decreases to range from 2 to 7
ng/ml 2 days post dose.

Excretion: length of time and route:
A liquid chromatographic method with fluorescence detection indicates that after oral administration of 0.3 mg
ivermectin per kg bodyweight, the liver (target tissue) has average residues ranging from 72 ppb at 1 day post dose to 8 ppb at 7 days post dose.
At early time periods fat had higher residues than liver. By 5 days post dose the liver and fat residues were equivalent. Fat averaged 145 ppb at 1 day, declining to 9 ppb at 7 days.
Muscle and kidney had lower residues at all withdrawal time periods studied.

6 PHARMACEUTICAL PARTICULARS
6.1 List of excipients
Propylene Glycol
Polysorbate 80
Benzyl Alcohol
Disodium Phosphate Dodecahydrate
Sodium Dihydrogen Phosphate Dihydrate
PurifiedWater

6.2 Incompatibilities
None known

6.3 Shelf-life
Shelf-life of the veterinary medicinal product as packaged for sale: 2 years

6.4 Special precautions for storage
Do not store above 25°C. Protect from direct sunlight.

6.5 Nature and composition of immediate packaging
The product is packaged in polyethylene backpacks containing 1 litre, 2.5 litres and 5 litres, and in polyethylene
jerrycans containing 1 litre.
Not all pack sizes may be marketed.

6.6 Special precautions for the disposal of unused veterinary medicinal products or waste materials
Unused product or waste material should be disposed of in accordance with current practice for pharmaceutical waste under national waste disposal regulations.
Studies indicate that when ivermectin comes in contact with the soil, it readily and tightly binds to the soil and becomes inactive over time.
Do not contaminate lakes and streams with unused product or waste material as free ivermectin may adversely affect fish and certain water borne organisms.#

7 MARKETING AUTHORISATION HOLDER
Merial Animal Health Ltd,
PO Box 327,
Sandringham House,
Harlow Business Park,
Harlow,
Essex CM19 5TG,
England.

8 MARKETING AUTHORISATION NUMBER(S)
VPA 10857/018/001

9 DATE OF THE FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION
30th September 2009

10 DATE OF REVISION OF THE TEXT
31st March 2011

Drench correctly
Sheep Oral Drench

The drenching technique is a vital part of ensuring that the wormer does its job effectively.
Make sure the sheep are properly restrained and cannot leap around when they are being drenched so they swallow the whole amount.
Sheep can also suffer serious injury, or even death, if they are unrestrained and the gun penetrates the tissues at the back of the mouth.
Place a hand under the head and tilt slightly to the side.
Slot the nozzle in the gap between molar and incisor teeth and then over the back of the tongue.
If the wormer is just put into the mouth, it will bypass the rumen as it escapes down the oesophageal groove and will be less effective.
This is particularly important for white (BZ) drenches.

Dosing Weigh – do not guess Underestimating the weight of sheep is a common cause of underdosing. Select and weigh the biggest sheep in the group to determine the correct dose. If there is a wide range of weights, consider splitting the group, then weigh the heaviest in each section. Do not forget to check that the weigh crate is accurate before starting!

Calibrate and maintain the drench gun
Always check the gun is delivering the right amount before you drench. Remove the plunger from a 10 ml syringe, put a thumb over the end and squirt the dose into it, making sure there are no air bubbles left. Adjust the gun until the dose delivered is correct. Drenching guns should also be well maintained and replaced regularly. Clean with warm soapy water after use and check springs and tubes to make sure there are no kinks that will form air bubbles.

Withholding food
Research has shown that the efficacy of the white (BZ) and clear (AV) drenches can be improved by withholding food for 12–24 hours before treatment. It is not advised to deprive heavily pregnant ewes of food, so if you treat this class of stock with anthelmintics, you may wish to use yellow drenches (LV) because their efficacy is less dependent on rumen fill.

Storage
Wormers should be stored securely, away from direct sunlight at 4–25°C. Check the use-by date and, once open, use within the time shown on the packaging. Shake white (BZ) products well before use.

 

Delivery Information

Delivery Service

Here at Agridirect we have joined forces with DPD to ensure all packages are delivered promptly and safely to you. We ship to all mainland countries within the EU. Deliveries take place Monday to Friday excluding bank holidays. Once your order has been dispatched from our warehouse you will be notified by email. If there is a delay with your order for any reason you will be contacted immediately. 

Due to Brexit we are temporarily unable to ship to the UK. Shipping to Northern Ireland will remain in place.

Delivery Times
Ireland (ROI & NI) EU (Mainland Only)
2-4 Working Days 4-6 Working Days

Some products have an extended delivery time, this is noted on the products.

Delivery Rates

Country Orders Under €129 Orders Over €129
Ireland (ROI & NI) €7.99 €0.00
Austria €24.99 €17.00
Belgium €21.99 €14.00
Czech Republic €24.99 €17.00
Denmark €24.99 €17.00
Finland €36.99 €29.00
France €21.99 €14.00
Germany €21.99 €14.00
Hungary €28.99 €21.00
Italy €34.99 €23.00
Luxenburg €21.99 €14.00
Netherlands €21.99 €14.00
Poland €21.99 €17.00
Portugal €36.99 €29.00
Slovakia €28.99 €21.00
Slovenia €28.99 €21.00
Spain €34.99 €27.00
Sweden €34.99 €27.00

 

A selection of the products we sell are only licensed for sale within the Republic Of Ireland and can not be shipped outside of the country. These products are noted as only being available within the Republic of Ireland on the individual product pages.

There may be an addition charge on certain bulky items. This charge will be clearly marked on an applicable products and will be explained on the checkout page before payment has been made.

Agridirect Returns Policy

We’re sorry your purchase didn’t work out. But don’t worry; we have a great returns policy to help you out.

All purchases can be returned to us within 14 days of delivery and returned goods must be received within 14 days from the date you informed us of the return.

Purchases may be opened for inspection but must not be used and must be repackaged securely in the original packaging if you wish to return it.

If we discover goods have been used or there has been a loss in value of the goods due to damage to the goods, while in your care or whilst being returned to us, we will reduce the amount refunded, which may amount to the full cost of the product, to cover loss of value of goods.

All returns should be complete which includes boxes, manuals and accessories that may have been included with the order.

All returns must be packaged appropriately for shipping, we will not accept responsibility for damages or loss which occur during shipping of a return product.

We accept no responsibility for goods damaged or lost while in transit to us. 

How do I return a product?

We have partnered with DPD to make your returns process easy and secure. simply follow the steps below and bring your package to an official DPD pickup point.

1) All returns must be accompanied with a fully filled out returns form which can be downloaded here.

2) To print off your return label click here or visit www.dpd.ie/returns and follow the on-screen instructions. Make sure and use your order number as your reference.

  • Select “Continue as Guest”
  • Select “Agridirect” from the drop-down menu
  • Select your reason for returning
  • Select the size of the package you wish to return
  • Accept DPD’s terms and conditions
  • Fill in your payment details
  • Fill in your own details
  • Follow the instructions to print off your label

3) Bring your package to a DPD pickup point. To find your nearest drop off point here.

Once the returned product has been received into our warehouse and been fully inspected a refund will be issued.

If you choose not to use the DPD returns service we recommend that you use a method that can be tracked.

For the return of bulk products please contact us at sales@agridirect.ie

I have received a damaged product from you, what should I do?

First off, if you have received a damaged electrical product from us, do not plug it in. Any electrical products that are plugged in are deemed ‘as used and accepted’ and are not accepted as returns. All damages must be reported to us via phone or email within 24hours of receipt of goods. Please ensure you check your items upon delivery.

How do I begin the returns process?

If you wish to begin the return process, please email us at sales@agridirect.ie and ensure the following information is included in your email. Your name, phone number, Order id, the item you wish to return, reason for return and if the product is damaged we require photos of the product.

Once you have sent us all required information a member of our team will assess your claim and will contact you as soon as possible. Please hold off on returning products until a member of our team has called you to confirm.

Refunds

Once the returned product has been returned to us and fully inspected a refund will be issued.

Please Note: A typical timeline for a refund to show in your account is up to 10 working days from the date processed, depending on your bank.

 

 

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