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Heptavac P Plus
Heptavac P Plus
Heptavac P Plus
Heptavac P Plus
Heptavac P Plus
Heptavac P Plus

Heptavac P Plus

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2-4 Days
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This product is only licensed for sale in the Republic Of Ireland

Heptavac-P Plus is an injectable immunisation which reduces mortality in sheep and is used in the control of pasteurellosis pneumonia and clostridial diseases in sheep such as lamb dysentery, pulpy kidney, struck, tetanus,braxy, blackleg and black disease. Vaccinating your flock with Heptavac-P Plus not only protects your sheep against these conditions but also reduces mortality rates throughout your flock.

Active Ingredient: Clostridium perfringens beta toxoid inducing, Clostridium perfringens epsilon toxoid inducing , Clostridium septicum toxoid inducing, Clostridium tetani toxoid inducing, Clostridium novyi toxoid inducing, Clostridium chauvoei cells and equivalent toxoid inducing 

Target Species: Sheep and Lambs from 3 weeks

Treats and Controls: Pneumonia, lamb dysentery, pulpy kidney, struck, tetanus,braxy, blackleg and black disease

Administration Method: Subcutaneous injection (under the skin)

Withdrawal Time: There is no withdrawal time for this product

Dosage: 2 ml per animal. After the initial vaccination a second dose should be given no less than 4 weeks and no more than 6 weeks after.

Body Weight Dose Volume Doses Per Pack
50ml 100ml 250ml 500ml
All Sizes 2ml 25 50 125 250

Always read the label and all enclosed information for Heptavac P Plus before administering to animals!

Pasteurellosis Pneumonia
One of the biggest killer of sheep in Ireland is pasteurellosis pneumonia. The organism that causes this disease is carried on the tonsils of most sheep and when the animals are stressed or run down their immune system is lowered and the disease can take hold.

Clostridial Diseases

Clostridial Diseases such as lamb dysentery, pulpy kidney, struck, tetanus,braxy, blackleg and black disease can all be fatal to sheep. The organisms that cause clostridial diseases can commomly be found in soil and when conditions are right they can even multiply throughout the soil. These organisms can also live in the stomach of sheep with out causing any damage and then spread throuth the soil via the animals manure. When the conditions are correct for the organism they release toxins which when the sheep are stressed can be fatal.

What causes a sheep to be stressed?

Transport: Long journeys and crowded transport conditions.
Nutritional Imbalances: Underfeeding or over grazing can both lead to imbalances in the sheep's needs and can cause ill health.
Weather: Extreme heat, humidity, or cold can all cause a sheep to be stressed.
Parasites: Parasites such as worms and fluke can lower the immune system and stress the animal.
Confinement: Overcrowded confinement or long periods of confinement.
Handling: Especially for wilder sheep that are not handled very often.
Weaning: The Weaning of Lambs can be extremely stressful.
Vaccinating your sheep with Heptavac-P Plus will protect your sheep at times of stress and reduce mortality rates by protecting against pasteurellosis pneumonia and clostridial diseases.
This Product is only licensed for sale in the Republic of Ireland

Click here to Download Data Sheet

Summary of Product Characteristics

Heptavac P Plus (IT: Heptavac P)

Active substances:
per ml:
Clostridium perfringens beta toxoid inducing                            ≥ 10  IU
Clostridium perfringens epsilon toxoid inducing                        ≥ 5    IU
Clostridium septicum toxoid inducing                                        ≥ 2.5 IU
Clostridium tetani toxoid inducing                                              ≥ 2.5 IU
Clostridium novyi toxoid inducing                                              ≥ 3.5 IU
Clostridium chauvoei cells and equivalent toxoid inducing        ≥ 0.5 guinea pig PD90

Formalin killed cells of the epidemiologically most important serotypes of Mannheimia haemolytica and Pasteurella trehalosi grown under iron restricted conditions: 5x108 cells per strain

Aluminium hydroxide gel  400 mg

Thiomersal  0.13 mg (preservative)

For a full list of excipients, see section 6.1.

Suspension for injection.

4.1       Target species 

4.2       Indications for use, specifying the target species
For the active immunisation of sheep as an aid in the control of lamb dysentery, pulpy kidney, struck, tetanus, braxy, blackleg, black disease, clostridial metritis caused by Clostridium perfringens types B, C and D, Cl.septicum, Cl.novyi, Cl.chauvoei and Cl.tetani
The vaccine may be used as an aid in the control of pneumonic pasteurellosis in sheep of all ages from a minimum age of 3 weeks and in the control of systemic pasteurellosis in weaned fattening and breeding sheep.

The vaccine may be used in pregnant ewes as an aid in the control of lamb dysentery, pulpy kidney, tetanus and pasteurellosis in their lambs provided that the lambs receive sufficient immune colostrum during the first 1-2 days of life.

4.3       Contraindications

4.4       Special warnings for each target species
Heptavac P Plus should not be used in lambs less than 3 weeks of age.
The nutritional and metabolic status of pregnant ewes is extremely important at the time of vaccination.
If in doubt, advice should be sought from a veterinary surgeon.

4.5       Special precautions for use
 i.          Special precautions for use in animals
In any group of animals, a small number of individuals may fail to respond to vaccination as a result of immunological incompetence.
Satisfactory immune responses will only be attained in healthy animals, thus it is important to avoid vaccination of animals which have intercurrent infection or metabolic disorder.
As with most killed vaccines, significant levels of immunity cannot be expected until two weeks after the second dose of vaccine in the primary vaccination course.

When handling sheep, stress should be avoided, particularly during the later stages of pregnancy when there is a risk of inducing abortion and metabolic disorders.

Because sheep are very sensitive to contamination of the injection site (which may result in non-product related tissue reactions and even in abscesses), it is advised to follow strict aseptic injection techniques.

ii.         Special precautions to be taken by the person administering the veterinary medicinal product to animals
In the case of accidental self-injection seek medical advice immediately and show the package leaflet or the label to the physician.

4.6    Adverse reactions (frequency and seriousness)
Occasionally hypersensitivity reactions may occur. In the event of an anaphylactic reaction appropriate treatment should be administered without delay.

Vaccination may result in small transient injection site reactions, usually characterised by swelling, possibly lasting for up to 3‑4 months after vaccination.

4.7    Use during pregnancy, lactation or lay
Ewes may be vaccinated during pregnancy as an aid in the control of lamb dysentery, pulpy kidney, tetanus and pasteurellosis in their lambs provided that the lambs receive sufficient immune colostrum during the first 1-2 days of life.

Regarding the handling of pregnant sheep see also section 4.5.

4.8    Interaction with other medicinal products and other forms of interaction
No information is available on the safety and efficacy of this vaccine when used with any other veterinary medicinal product.
A decision to use this vaccine before or after any other veterinary medicinal product therefore needs to be made on a case by case basis.

4.9       Amounts to be administered and administration route
The vaccine should be administered by subcutaneous injection in the lateral side of the upper neck observing aseptic precautions.  All breeding sheep not previously vaccinated with Heptavac P Plus must receive two injections, each of 2.0 ml, separated by an interval of 4-6 weeks.
Thereafter they must receive booster injections at intervals of not more than 12 months.
In adult breeding ewes these yearly booster injections should be given during the pre-lambing period, 4-6 weeks pre-lambing, as an aid in control of disease in their lambs.

On farms where the incidence of pasteurellosis is high, a supplementary booster injection using a Pasteurella vaccine may be required 2-3 weeks prior to expected seasonal outbreaks.

Heptavac P Plus should not be used in lambs less than 3 weeks of age due to the possible immunological incompetence of the very young lamb and competition from any maternally derived colostral antibodies.
Lambs being retained for fattening or subsequent breeding will require a full course of vaccination.
At a minimum age of 3 weeks these lambs should receive two injections, each of 2.0 ml, separated by an interval of 4-6 weeks. 
It should be noted that Heptavac P Plus is the recommended vaccine for breeding stock since it provides optimal aid in the control of the predominant clostridial diseases in adult sheep by active immunisation and in young lambs by passive immunisation.

The vaccine bottle must be shaken well before use.
The use of automatic vaccination equipment is recommended.
Since the bottle is non-collapsible, a vaccinator with a vented draw-off spike or similar device must be used.
The instructions supplied with such equipment should be noted and care should be taken to ensure the delivery of the full dose, particularly with the final few doses from the bottle.

The vaccine may be administered using a sterile needle and syringe, providing a fresh sterile needle is used each time the rubber cap is punctured, to avoid contamination of the remaining contents.
Syringes and needles must be from gamma irradiated packs or freshly sterilised by boiling for at least 20 minutes. 
No alcohol or other disinfectants should be used for sterilisation.

Evidence of efficacy of the Pasteurella/Mannheimia component of Heptavac P Plus was generated in an experimental infection model and it is not possible to provide duration of immunity information using this system. There are reports that active immunity will last for up to one year and that passive immunity will persist for up to 4 weeks after birth in lambs from ewes vaccinated with conventional Pasteurella vaccines.

Heptavac P Plus has been developed following research and development which resulted in the application of Plus ‘IRP’ technology for the manufacture of the Pasteurella/Mannheimia components of this vaccine.
The inclusion of these IRP components should provide enhanced efficacy and cross protection e.g. protection against serotype A12, which is not included in the vaccine, has been demonstrated.
Studies on the response of sheep to this vaccine show that two injections separated by an interval of 4-6 weeks are required to gain the full benefit of the ‘IRP’.

4.10    Overdose (symptoms, emergency procedures, antidotes), if necessary
Accidental overdosage is unlikely to cause any reaction other than described in section 4.6.
No adverse local or systemic reactions were noted in overdose studies (double dose) performed in pregnant ewes and lambs.

4.11  Withdrawal period
Zero days.

For the immunisation of sheep as an aid in the control of clostridial diseases and pasteurellosis.

ATCvet code:

6.1    List of excipients
Maleic acid,
Sodium chloride,

6.2    Incompatibilities
Do not mix with any other veterinary medicinal product.

6.3    Shelf life
Shelf-life: 24 months.
Once opened, the vaccine must be used within 10 hours.

6.4.   Special precautions for storage
Store between +2°C and +8°C in the dark. Do not freeze.

6.5    Nature and composition of immediate packaging
Low density polyethylene containers of 50, 100, 250 or 500 ml with rubber closure and aluminium cap.
Not all pack sizes may be marketed.

6.6       Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products
Any unused product or waste materials should be disposed of in accordance with national requirements.

Intervet UK Ltd
Walton Manor
Milton Keynes

Vm 01708/4468

Date: 17-12-2002/17-12-2007

Date: July 2010

Not applicable.

Sheep Subcutaneous injections

Subcutaneous injections need to be administered with care to ensure the product is placed under the skin and not into the fleece or muscle.
The sheep needs to be well restrained, and the skin ‘tented’ away from the underlying muscle.
The preferred injection site is 10–15 cm (4–6 inches) below the ear on the side of the neck (see diagram below). Usually a 1.6 cm (5/8 inch) needle is ideal.
After administration, the site should be gently massaged.

Delivery Information

Delivery Service

Here at Agridirect we have joined forces with DPD to ensure all packages are delivered promptly and safely to you. We ship to all mainland countries within the EU. Deliveries take place Monday to Friday excluding bank holidays. Once your order has been dispatched from our warehouse you will be notified by email. If there is a delay with your order for any reason you will be contacted immediately. 

Due to Brexit we are temporarily unable to ship to the UK. Shipping to Northern Ireland will remain in place.

Delivery Times
Ireland (ROI & NI) EU (Mainland Only)
2-4 Working Days 4-6 Working Days

Some products have an extended delivery time, this is noted on the products.

Delivery Rates

Country Orders Under €129 Orders Over €129
Ireland (ROI & NI) €7.99 €0.00
Austria €24.99 €17.00
Belgium €21.99 €14.00
Czech Republic €24.99 €17.00
Denmark €24.99 €17.00
Finland €36.99 €29.00
France €21.99 €14.00
Germany €21.99 €14.00
Hungary €28.99 €21.00
Italy €34.99 €23.00
Luxenburg €21.99 €14.00
Netherlands €21.99 €14.00
Poland €21.99 €17.00
Portugal €36.99 €29.00
Slovakia €28.99 €21.00
Slovenia €28.99 €21.00
Spain €34.99 €27.00
Sweden €34.99 €27.00


A selection of the products we sell are only licensed for sale within the Republic Of Ireland and can not be shipped outside of the country. These products are noted as only being available within the Republic of Ireland on the individual product pages.

There may be an addition charge on certain bulky items. This charge will be clearly marked on an applicable products and will be explained on the checkout page before payment has been made.

Agridirect Returns Policy

We’re sorry your purchase didn’t work out. But don’t worry; we have a great returns policy to help you out.

All purchases can be returned to us within 14 days of delivery and returned goods must be received within 14 days from the date you informed us of the return.

Purchases may be opened for inspection but must not be used and must be repackaged securely in the original packaging if you wish to return it.

If we discover goods have been used or there has been a loss in value of the goods due to damage to the goods, while in your care or whilst being returned to us, we will reduce the amount refunded, which may amount to the full cost of the product, to cover loss of value of goods.

All returns should be complete which includes boxes, manuals and accessories that may have been included with the order.

All returns must be packaged appropriately for shipping, we will not accept responsibility for damages or loss which occur during shipping of a return product.

We accept no responsibility for goods damaged or lost while in transit to us. 

How do I return a product?

We have partnered with DPD to make your returns process easy and secure. simply follow the steps below and bring your package to an official DPD pickup point.

1) All returns must be accompanied with a fully filled out returns form which can be downloaded here.

2) To print off your return label click here or visit and follow the on-screen instructions. Make sure and use your order number as your reference.

  • Select “Continue as Guest”
  • Select “Agridirect” from the drop-down menu
  • Select your reason for returning
  • Select the size of the package you wish to return
  • Accept DPD’s terms and conditions
  • Fill in your payment details
  • Fill in your own details
  • Follow the instructions to print off your label

3) Bring your package to a DPD pickup point. To find your nearest drop off point here.

Once the returned product has been received into our warehouse and been fully inspected a refund will be issued.

If you choose not to use the DPD returns service we recommend that you use a method that can be tracked.

For the return of bulk products please contact us at

I have received a damaged product from you, what should I do?

First off, if you have received a damaged electrical product from us, do not plug it in. Any electrical products that are plugged in are deemed ‘as used and accepted’ and are not accepted as returns. All damages must be reported to us via phone or email within 24hours of receipt of goods. Please ensure you check your items upon delivery.

How do I begin the returns process?

If you wish to begin the return process, please email us at and ensure the following information is included in your email. Your name, phone number, Order id, the item you wish to return, reason for return and if the product is damaged we require photos of the product.

Once you have sent us all required information a member of our team will assess your claim and will contact you as soon as possible. Please hold off on returning products until a member of our team has called you to confirm.


Once the returned product has been returned to us and fully inspected a refund will be issued.

Please Note: A typical timeline for a refund to show in your account is up to 10 working days from the date processed, depending on your bank.



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