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Flukiver Oral Drench (Closantel)
Flukiver Oral Drench (Closantel)
Flukiver Oral Drench (Closantel)
Flukiver Oral Drench (Closantel)

Flukiver Oral Drench (Closantel)

was: €~~productWasPrice~~Our Price: 54.00



Availability: In Stock
Delivery Time: 5-6 Days

Flukiver 5% Oral Drench is a highly effective orally administered treatment against immature and mature fluke, larval stages nasal bot fly in sheep. Flukiver 5% Oral Drench also fights against immature and adult stages of haemonchus contortus, including benzimidazole resistant strains. It has also been found at the time of treatment that ticks feeding on the sheep produce fewer viable eggs.

Active Ingredient: Closantel

Target Species: Sheep

Treats and Controls: Liver fluke, larval stage nasal bots, haemonchus contortus

Administration Method: Oral Drench

Withdrawal Time: 42 days for animals intended for meat and offal, not permitted for use on animals producing milk for human consumption.

Dosage:1 ml per 5 kg of bodyweight

Bodyweight in kgDose in mlDoses per 1 ltr bottleDoses per 2.5 ltr bottleDoses per 5 ltr bottle

Always read the label and all enclosed information for Flukiver before administering to animals!

Liver fluke is one of the biggest dangers to the sheep industry causing death and lost production, which in turn costs farmers millions of euro per year. The loss of profit liver fluke can cause for the farmers is caused by many different factors, some of which are:
  • Acute or untreated chronic infections which can lead to death
  • Reduced lambing percentages and ewe fertility
  • Reduced weight in new born lambs
  • Infected lambs take longer to reach finish weight
  • Reduced and lower quality wool yields
  • Heightened susceptibility to clostridial infections
Flukiver 5% oral drench contains clostantel, a flukicide in a class of it's own with an effective two stage system in the fight against fluke.
Stage 1: Kills adult, immature fluke as well as fluke that is resistant to triclabendazole.
Stage 2: The continuous action of Flukiver 5% oral drench results in:
  • Smaller fluke
  • Production of eggs is drastically delayed
  • The number of eggs laid is reduced
  • The number of eggs hatching is reduced
  • The re-contamination of pasture is reduced
Rotate and protect:
Since there is a limited amount of products available for the treatment of fluke and there is an ever growing resistance to triclabendazole (the active ingredient used in other popular flukicides), it is important to protect ALL flukicide products. It is a necessity that all sheep farmers establish a competent control of fluke for the future.
Triclabendazole resistance is a reality and a strategic rotation program with Flukiver and/or Sperverm can reduce the danger of fluke developing a resistance on your farm.
"An essential part of any strategic fluke control programme"
This product is only licensed for sale within the Republic of Ireland
Data Sheets

Flukiver 5% w/v Oral Suspension

Active Substance
Closantel (as Clostanel sodium) 50 mg/ml
For a full list of excipients, see section 6.1

Oral suspension.
A white suspension

4.1 Target Species
Sheep and lambs.

4.2 Indications for use, specifying the target species
For the treatment and control of adult and immature liver fluke, haematophagous nematodes and larval stages of some
arthropods in sheep.
Liver fluke:
Fasciola hepatica (average efficacy against 6 week immature stages is 86%)
Fasciola gigantica
Haematophagous nematodes
Haemonchus contortus (including benzimidazole resistant strains)
Chabertia ovina
Gaigeria pachyscelis
Oestrus ovis (Sheep Nasal Bot Fly)
Ticks (lxodes ricinus) feeding on sheep at the time of treatment are likely to produce fewer viable eggs.

4.3 Contraindications
Do not use in animals with known hypersensitivity to the active ingredient.

4.4 Special warnings for each target species
Care should be taken to avoid the following practices because they increase the risk of development of resistance and could
ultimately result in ineffective therapy:
• Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
• Underdosing which may be due to underestimation of bodyweight, misadministration of the product, or lack of
calibration of the dosing device.
Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count
Reduction Test). Where the results of the tests strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to
another pharmacological class and having a different mode of action should be used.

4.5 Special precautions for use
Special precautions for use in animals:
Do not overdose. Care should be taken when administering the product to avoid causing injury to the pharynx. Appropriate
drenching equipment to allow accurate dosing should be used.
Special precautions to be taken by the person administering the veterinary medicinal product to animals:
Wash hands after administration.

4.6 Adverse reactions (frequency and seriousness)
At therapeutic doses Flukiver is not toxic and causes no side effects.

4.7 Use during pregnancy, lactation or lay
Flukiver can be used at any time during pregnancy and during the lactating period. See section 4.11.

4.8 Interaction with other medicinal products and other forms of interaction
None known.

4.9 Amounts to be administered and administration route
For oral administration.
If animals are to be treated collectively rather than individually, they should be grouped according to their bodyweight and dosed
accordingly, in order to avoid under- or overdosing.
Shake well before use.
1 ml of Flukiver per 5 kg bodyweight (i.e. 10 mg closantel per kg bodyweight).
Bodyweight of animals should be assessed accurately.
For example:
Bodyweight Dose
Up to 5 kg 1 ml
10 kg 2 ml
20 kg 4 ml
30 kg 6 ml
40 kg 8 ml
50 kg 10 ml
60 kg 12 ml
70 kg 14 ml
80 kg 16 ml
Fluke infestations
All sheep on infested pasture should be dosed at regular intervals during the fluke season (September - March).
Since closantel has been shown to delay egg laying for up to 13 weeks after artificial infection, treatment intervals of 10-12
weeks throughout the fluke season are recommended. In severe fluke seasons more frequent dosing may be necessary. The
treatment of ewes with a single dose of Flukiver in the spring will contribute to reducing pasture contamination during the
following summer and autumn.
Any sheep brought in from liver fluke infested areas should be dosed before they join the flock.
H. contortus
For the treatment and prevention of benzimidazole resistant and susceptible H. contortus, dose at lambing to help prevent
pasture contamination by infected ewes. Treat all animals at 6 weekly intervals during high risk periods in summer and
The veterinary surgeon should give advice regarding appropriate dosing programmes and stock management to achieve adequate
parasite control.

4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
Symptoms of acute overdosage include decreased vision or blindness, anorexia, inco-ordination and general weakness.

4.11 Withdrawal Period(s)
Meat: 42 days
Not authorised for use in ewes producing milk for human consumption including during the dry period. Do not use
within 1 year prior to the first lambing in ewes intended to produce milk for human consumption.

Pharmacotherapeutic group: Anthelmintics, closantel.
ATCvet code: QP52AG09

5.1 Pharmacodynamic properties
Flukiver 5% oral suspension contains the salicylanilide closantel, a synthetic antiparasitic agent with high efficacy against
liver fluke and haematophagous nematodes in sheep and goats and against the larval stages of some arthropods in sheep.
Closantel uncouples the mitochondrial oxidative phosphorylation resulting in inhibition of ATP synthesis. This induces a
marked change in the energy metabolism of the parasite, which finally kills it.

5.2 Pharmacokinetic properties
Closantel is rapidly absorbed into the systemic circulation with peak plasma levels at 24-48 hours after dosing. The
bioavailability of an oral dose is 50% of a parenteral one. In plasma, closantel is bound to albumin for more than 99%. As
a result, tissue distribution is very limited. On average, tissue levels are 15 times lower than plasma levels. The
elimination half-life of closantel from plasma and tissues is approximately 2 to 4 weeks in sheep and about 8 days in goats.
Closantel is metabolised only to a slight extent and the main excretion route is the faeces via the bile. The urinary
excretion is negligible.

6.1 List of excipients
Propylene Glycol
Microcrystalline Cellulose and Carmellose sodium
Hypromellose 15 cps
Sodium Laurilsulfate
Simethicone emulsion 30 %
Purified water

6.2 Incompatibilities
None known

6.3 Shelf-life
Shelf-life of the veterinary medicinal product as packaged for sale: 4 years

6.4 Special precautions for storage
Do not store above 25oC.
Protect from light

6.5 Nature and composition of immediate packaging
The product is packed in white high density polyethylene flexipacks containing 1 litre, 2.5 litres and 5 litres of product.
Closures: Tamper evident high density polyethylene cap (screw-fit) with high density polyethylene screw fit nozzle cap.
Not all pack sizes may be marketed.

6.6 Special precautions for the disposal of unused veterinary medicinal products or waste materials
Any unused product or waste material should be disposed of in accordance with national requirements.

Eli Lilly & Company Limited
Elanco Animal Health
Lilly House
Priestly Road
RG24 9NL

VPA 10047/037/001

30th September 2009

February 2013



Delivery Information

Here at Agridirect we have joined forces with DPD to ensure all packages are delivered promptly and safely to you. We ship to all mainland countries within the EU. Deliveries take place Monday to Friday excluding bank holidays. Once your order has been dispatched from our warehouse you will be notified by email. If there is a delay with your order for any reason you will be contacted immediately. 

Delivery Times
Ireland (ROI & NI)United Kingdom (Mainland Only)EU (Mainland Only)
1-3 Working Days2-4 Working Days4-6 Working Days

Some product have an extended delivery time, this is noted on the products.

Delivery Rates

Delivery Rates
CountryOrders Under €99Orders Over €99
Ireland (ROI & NI)€6.99€0.00
Czech Republic€19.99€13.00



A selection of the products we sell are only licensed for sale within the Republic Of Ireland and can not be shipped outside of the country. These products are noted as only being available within the Republic of Ireland on the individual product pages

There may be an addition charge on certain bulky items. This charge will be clearly marked on an applicable products and will be explained on the checkout page before payment has been made.



Returns Policy

We’re sorry your purchase didn’t work out. But don’t worry; we have a great returns policy to help you out.

All purchases can be returned to us within 14 days of delivery and returned goods must be received within 14 days from the date you informed us of the return.

Purchases may be opened for inspection but must not be used and must be repackaged securely in the original packaging if you wish to return it.

If we discover goods have been used or there has been a loss in value of the goods due to damage to the goods, while in your care or whilst being returned to us, we will reduce the amount refunded, which may amount to the full cost of the product, to cover loss of value of goods.

We accept no responsibility for goods damaged or lost while in transit to us. 

The cost of the return, including all packaging and freight, lies solely with the consumer.

I have received a damaged product from you, what should I do?

First off, if you have received a damaged electrical product from us, do not plug it in. Any electrical products that are plugged in are deemed ‘as used and accepted’ and are not accepted as returns. All damages must be reported to us via phone or email within 24hours of receipt of goods. Please ensure you check your items upon delivery.

How do I begin the returns process?

If you wish to begin the return process, please email us at and ensure the following information is included in your email. Your name, phone number, Order id, the item you wish to return, reason for return and if the product is damaged we require photos of the product.

Once you have sent us all required information a member of our team will assess your claim and will contact you as soon as possible. Please hold off on returning products until a member of our team has called you to confirm.



All returns must be the complete product which includes boxes, manuals and accessories that may have been include with the order.

All returns must be packaged appropriately for shipping, we will not accept responsibility for damages or loss which occur during shipping of a return product.

Address: Please ship the product to the following address: Agridirect, Drumrahan Retail, Church Street, Ballyconnell, Co Cavan


Once the returned product has been returned to us and fully inspected a refund will be issued.

Please Note: A typical timeline for a refund to show in your account is up to 10 working days from the date processed, depending on your bank.

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