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Closamectin Pour-On
Closamectin Pour-On
Closamectin Pour-On
Closamectin Pour-On
Closamectin Pour-On
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Closamectin Pour-On


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Closamectin Pour-on for cattle is a ready to use pour-on solution that is used in the treatment and control of mixed trematode (fluke) and nematode or arthropod infestations due to roundworms, lungworms, eye worms, warbles, mites and lice. Closamectin Pour-on uses a unique mixture of ivermectin (for the treatment of lice, worms and ticks) and closantel (for the treatment of liver fluke and gastrointestinal roundworm).Closamectin pour-on is highly effective and extremely easy to use compared to injections or drenches. The ease and efficiency of this product will save farmers both time and money.

Active Ingredient: Ivermectin, Closantle

Target Species: Cattle, sheep

Treats and Controls: Gastro-intestinal worm, lungworm,eye worms, warbles, lice, mange mites, immature and mature fluke

Administration Method: Pour-On

Withdrawal Time:28 days for cattle intended for meat and offal, not suitable for cattle producing milk for human consumption.

Dosage for cattle: 1 ml per 10 kg of bodyweight.

Body WeightDose VolumeNumber of full doses per pack:
500ml1 Litre2.5 Litre5 Litre
50kg5 ml1002005001000
100kg10 ml50100250500
150kg15 ml3366166333
200kg20 ml2550125250
250kg25 ml2040100200
300kg30 ml163383166
350kg35 ml142871142
400kg40 ml122562125
450kg45 ml112255111
500kg50 ml102050100
550kg55 ml9184590
600kg60 ml8164183

Always read the label and all enclosed information for Closamectin before administering to animals!

Field Tests

Field tests have shown that ClosamectinPour-on is highly effective in the fight against ostertagia ostertagi

  • Killed 99.8% of adult fluke aged 12 weeks following infection
  • Killed 98.3% of immature fluke aged 7 weeks following infection
  • Killed 95.7% of Cooperia oncophora in field tests
  • Killed 99.5% of Cooperia surnabada in field tests

Closamectin Treatment Regime

It is recomended that treating beef cattle at least twice a year is the most effective way of controlling the fluke problem on your farm. 

Housing: Cattle should be treated at the time of housing or just after housing. A second treatment may be needed if the cattle are housed early or if the area is highly susceptible to contamination.

Turnout:Cattle should be treated at 8 to 10 weeks after turnout. This treatment will kill fluke that have been picked up by cattle as soon as they were turned out. This treatment will also help reduce the reinfection of pastures. 

Outwintering: For cattle who are outwintered a treatment should be given in the late autumn to early winter, a second treatment may be needed in January/February.

Bought in cattle: All bought in livestock should be treated and quarantined for at least 48 hours, this will help protect your herd from infections introduced from new cattle

"Choose Closamectin Pour on… The easy and effective way to treat  fluke, worms and lice."

Summary of Product Characteristics

1 NAME OF THE VETERINARY MEDICINAL PRODUCT
Closamectin Pour-On Solution for Cattle.

2 QUALITATIVE AND QUANTITATIVE COMPOSITION
Active ingredient(s)
Ivermectin 5 mg/mL
Closantel (as closantel sodium) 200 mg/mL
Excipients
Brilliant Blue FCF (E133) 0.1 mg/mL
For a full list of excipients see section 6.1.

3 PHARMACEUTICAL FORM
Pour-On solution.
A clear blue/green solution.

4 CLINICAL PARTICULARS
4.1 Target Species
Cattle.
Active ingredient(s)
Ivermectin 5 mg/mL
Closantel (as closantel sodium) 200 mg/mL
Excipients
Brilliant Blue FCF (E133) 0.1 mg/mL
For a full list of excipients see section 6.1.

4.2 Indications for use, specifying the target species
For the treatment of mixed trematode (fluke) and nematode or arthropod infestations due to roundworms, lungworms, eyeworms,
warbles, mites and lice of cattle.
Gastrointestinal roundworms (adults and fourth stage larvae)
Ostertagia ostertagi (including inhibited O. ostertagi), Haemonchus placei, Trichostrongylus axei, Trichostrongylus
colubriformis, Cooperia spp, Oesophagostomum radiatum, Nematodirus helvetianus (adult), Strongyloides papillosus (adult).
Lungworms (adult and fourth stage larvae)
Dictyocaulus viviparus
Trematodes (adult and late immatures)
Fasciola gigantica
Fasciola hepatica
Treatment of fluke at 12 weeks (mature) >95% efficacy.
Treatment of fluke at 7 weeks (late immature) >95% efficacy.
Eyeworms (adult)
Thelazia spp
Cattle grubs (parasitic stages)
Hypoderma bovis, Hypoderma lineatum
Lice
Linognathus vituli, Haematopinus eurysternus, Damalinia bovis
Mange Mites
Chorioptes bovis, Sarcoptes scabiei var bovis

4.3 Contraindications
Do not use in cases of known hypersensitivity to the active substances.
Do not apply to areas of skin which have mange, scabs or other lesions or to areas contaminated with mud or manure.
Avermectins may not be well tolerated in non-target species (cases of intolerance with fatal outcome are reported in dogs –
especially Collies, Old English Sheepdogs and related breeds or crosses, and also in turtles/tortoises).

4.4 Special warnings for each target species
Care should be taken to avoid the following practices because they increase the risk of development of resistance and could
ultimately result in ineffective therapy.
- Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
- Underdosing which may be due to underestimation of bodyweight, misadministration of the product, or lack of calibration of the
dosing device.
The effect of rain on the pour-on formulation at the time of and after application has not been investigated. For maximum effect
animals should be kept indoors or undercover following treatment, when there is rain or an imminent risk of rain.
Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g., Faecal Egg
Count Reduction Test). Where the results of the tests strongly suggest resistance to a particular anthelmintic, an anthelmintic
belonging to another pharmacological class and having a different mode of action should be used.
Resistance to ivermectin has been reported in Cooperia spp in cattle. Therefore the use of this product should be based on local
epidemiological information about the susceptibility of the Cooperia spp and recommendations on how to limit further selection
for resistance to anthelmintics.

4.5 Special precautions for use
(i)Special precautions for use in animals:
None
(ii)Special precautions to be taken by the person administering the veterinary medicinal product to animals:
The veterinary medicinal product may be irritating to human skin and eyes and the user should be careful not to apply it to himself
or other persons. Operators should wear nitrile rubber gloves and boots with a waterproof coat when applying the product.
Protective clothing should be washed after use. If accidental skin contact occurs, wash the affected area immediately with soap
and water. If accidental eye exposure occurs, flush the eyes immediately with water and get medical attention.
Do not smoke or eat whilst handling the product. Wash hands after use. Use only in well ventilated areas or outdoors.
(iii)Other Precautions Regarding the Environment.
Treated cattle should not have direct access to ponds, streams or ditches for 14 days after treatment.

4.6 Adverse reactions (frequency and seriousness)
Undesirable effects are not expected when the product is used at the recommended dose rate

4.7 Use during pregnancy, lactation or lay
The product is safe for use during pregnancy and lactation. However, the product is not permitted for use in animals
producing milk for human consumption, including pregnant animals intended to produce milk for human consumption.

4.8 Interaction with other medicinal products and other forms of interaction
None known.

4.9 Amounts to be administered and administration route
The veterinary medicinal product should be administered topically at a dosage rate of 500μg ivermectin per kg bodyweight and 20
mg closantel per kg bodyweight (1 mL per 10 kg).
The formulation should be applied along the midline of the back in a narrow strip between the withers and the tail head.
Assess bodyweight carefully prior to administration.
The timing for treatment should be based on epidemiological factors and should be customised for each individual farm. A dosing
programme should be established by a veterinary professional.
* Dose rate 1 ml per 10 kg bodyweight

4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
At doses of three times the recommended dose, no significant clinical signs were recorded.
Ivermectin
No antidote has been identified. Symptomatic treatment may be beneficial.
Closantel like other salicylanilides is a potent uncoupler of oxidative phosphorylation and the safety index is not as high as is the
case of many other anthelmintics. However where used as directed there are unlikely to be any untoward effects. Signs of
overdosage can include slight loss of appetite, loose faeces, decreased vision and increased frequency of defecation. High doses
may cause blindness, hyperventilation, general weakness and inco-ordination, hyperthermia, convulsions, tachycardia and in
extreme cases death. Treatment of overdosage is symptomatic as no antidote has been identified.

4.11Withdrawal Period(s)
Cattle must not be treated within 28 days of slaughter for human consumption.
Not permitted for use in animals producing milk for human consumption, including pregnant animals intended to
produce milk for human consumption.

5 PHARMACOLOGICAL or IMMUNOLOGICAL PROPERTIES
ATC Vet Code: QP54AA51
Pharmacotherapeutic Group: Ivermectin, combinations.
Handy dosing guide Animals should be weighed and grouped according to bodyweight
to avoid under or over-dosing*
Bodyweight Dose Volume Number of full doses per pack
250 ml 1 litre 2.5 litre 5 litre
100 kg* 10 ml 25 100 250 500
150 kg 15 ml 16 66 166 333
200 kg 20 ml 12 50 125 250
250 kg 25 ml 10 40 100 200
300 kg 30 ml 8 33 83 166
350 kg 35 ml 7 28 71 142
400 kg 40 ml 6 25 62 125
450 kg 45 ml 5 22 55 111
500 kg 50 ml 5 20 50 100
550 kg 55 ml 4 18 45 90
600 kg 60 ml 4 16 41 83

5.1 Pharmacodynamic properties
Ivermectin is an endectocide with activity against a wide range of internal and external parasites. Ivermectin is a macrocylic
lactone and acts by inhibiting nerve impulses. It binds selectively and with high affinity to glutamate-gated chloride ion channels
which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride
ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the relevant parasites. Compounds of
this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gammaaminobutyric
acid (GABA). The margin of safety for compounds of this class is attributable to the fact that mammals do not have
glutamate-gated chloride channels. The macrocylic lactones have a low affinity for other mammalian ligand-gated chloride
channels and they do not readily cross the blood-brain barrier.
Closantel is a member of the salicylanilide class of anthelmintics. Salicylanilides are hydrogen (proton) ionophores (referred to as
oxidative phosphorylase uncouplers.)
The chemical structure of salicylanilides illustrate the possession of a detachable proton. This type of molecule is lipophilic and is
known to shuttle protons across membranes, in particular the inner mitochondrial membrane. Closantel acts by uncoupling
oxidative phosphorylation.
Closantel is a parasiticide with flukicide activity and efficacy against certain other helminths and arthropods.

5.2 Pharmacokinetic properties
After topical administration of Closamectin Pour-On to cattle at a dose rate of 500 microgram ivermectin per kg and 20 mg
closantel per kg the following parameters were observed: Ivermectin – Cmax of 19.13 ng/mL and AUC of 2440 ng.hr/mL;
Closantel – Cmax of 68.5 microgram/mL and AUC of 35207 microgram.hr/mL.
Ivermectin is only partially metabolised. In cattle, only about 1 to 2% is excreted in the urine the remainder is excreted in the
faeces, approximately 60% of which is excreted as unaltered drug. The remainder is excreted as metabolites or degradation
products. Salicylanilides are poorly metabolised and are excreted mainly unchanged. About 90% of closantel is excreted
unchanged in the faeces and urine in cattle.

6 PHARMACEUTICAL PARTICULARS
6.1 List of excipients
Brilliant Blue FCF (E133) Dye
Anhydrous Ethanol
Macrogol,
Cetearyl Ethylhexanoate
Isopropyl Myristate
Povidone
Denatonium Benzoate
Trolamine
Isopropylalcohol

6.2 Incompatibilities
None known.

6.3 Shelf-life
Shelf-life of the veterinary medicinal product as packaged for sale: 1 year.

6.4 Special precautions for storage
Do not store above 25°C.
Store upright in original container.
Protect from light.
Discard unused material. Avoid introduction of contamination.
If stored at temperatures below 0°C, Closamectin Pour-On Solution for Cattle may appear cloudy. Allowing to warm at room
temperature will restore the normal appearance without affecting efficacy.
Flammable – keep away from heat, sparks, open flame or other sources of ignition.

6.5 Nature and composition of immediate packaging
Translucent 250 mL and 1L HDPE containers with white HDPE caps and white 1L, 2.5L and 5L HDPE backpacks with white
polypropylene screw caps.
Not all packs sizes may be marketed.

6.6 Special precautions for the disposal of unused veterinary medicinal products or waste materials
EXTREMELY DANGEROUS TO FISH AND AQUATIC LIFE. Do not contaminate surface waters or ditches with
the product or used container. Any unused product or waste material should be disposed of in accordance with
national requirements.

7 MARKETING AUTHORISATION HOLDER
Norbrook Laboratories Limited
Station Works
Camlough Road
Newry
Co Down,
BT35 6JP
Northern Ireland

8 MARKETING AUTHORISATION NUMBER(S)
VPA 10999/124/001

9 DATE OF THE FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION
7th August 2009

10 DATE OF REVISION OF THE TEXT
5th May 2010

At Agridirect we have joined forces with Fastway & DPD, to ensure your products are delivered to your door within 2-4 working days from time of order.

Our delivery charges are as follows:

Ireland

€4.99 for all orders UNDER €70

There is FREE delivery on all orders OVER €70 ( some exceptions apply on bulky products)

U.K. and France

€14.99 for all orders UNDER €70

€9.99 for all orders OVER €70

Delivery is from Monday to Friday ONLY

There may be an additional charge on certain bulky items. This charge will be detailed on any applicable product and will be explained before the checkout stage.

Returns Policy

We’re sorry your purchase didn’t work out. But don’t worry; we have a great returns policy to help you out.
 

All purchases can be returned to us within 14 days of delivery and returned goods must be received within 14 days from the date you informed us of the return.
 

Purchases may be opened for inspection but must not be used and must be repackaged securely in the original packaging if you wish to return it.
 

If we discover goods have been used or there has been a loss in value of the goods due to damage to the goods, while in your care or whilst being returned to us, we will reduce the amount refunded, which may amount to the full cost of the product, to cover loss of value of goods.
 

We accept no responsibility for goods damaged or lost while in transit to us. 
 

The cost of the return, including all packaging and freight, lies solely with the consumer.
 

I have received a damaged product from you, what should I do?

First off, if you have received a damaged electrical product from us, do not plug it in. Any electrical products that are plugged in are deemed ‘as used and accepted’ and are not accepted as returns. All damages must be reported to us via phone or email within 24hours of receipt of goods. Please ensure you check your items upon delivery.

How do I begin the returns process?

If you wish to begin the return process, please email us at sales@agridirect.ie and ensure the following information is included in your email. Your name, phone number, Order id, the item you wish to return, reason for return and if the product is damaged we require photos of the product.

Once you have sent us all required information a member of our team will assess your claim and will contact you as soon as possible. Please hold off on returning products until a member of our team has called you to confirm.

 

Packaging

All returns must be the complete product which includes boxes, manuals and accessories that may have been include with the order.

All returns must be packaged appropriately for shipping, we will not accept responsibility for damages or loss which occur during shipping of a return product.
 

Address: Please ship the product to the following address: Agridirect, Drumrahan Retail, Church Street, Ballyconnell, Co Cavan
 

Refunds

Once the returned product has been returned to us and fully inspected a refund will be issued.

Please Note: A typical timeline for a refund to show in your account is up to 10 working days from the date processed, depending on your bank.

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