Animec Injection 500ml (Ivermectin)

Animec Injection is a broad spectrum anti parasitic for cattle. It is used for the treatment and control of gastro-intestinal nematodes, lungworms, warbles, mange, mites and lice in beef and non lactating dairy cattle of all ages.

​Active Ingredient: Ivermectin

Target Species: Cattle

Administration Method: Subcutaneous injection (under the skin)

Treats and Controls: Gastro-intestinal nematodes, lungworms,  warbles, mange, mites and lice in cattle.

Withdrawal Time: 49 days for cattle intended for meat and offal, not permitted for use on cattle producing milk for human consumption.

Dosage for cattle: 1 ml per 50 kg of bodyweight 

Always read the label and all enclosed information for Animec Injection before administering to animals!

Key Features of  Animec Injection

• It is a broad spectrum anti parasitic for cattle.
• Treats and controls gastro-intestinal nematodes, lungworms, warbles, mange, mites and lice
• Used in beef and non lactating dairy cattle of all ages
• Reliable way to maximise the effect.
• Rapid delivery

Why use an injection over a pour-on?

• Injections are the most reliable way to maximise the effect of the active ingredient
• Injections guarantee the active ingredient is delivered rapidly and in high concentration
• With injections, factors such as skin and coat thickness, spillage of product and weather do not affect dosage 

This product is only licensed for sale within the Republic of Ireland

Click here to Download Data Sheet

1 NAME OF THE VETERINARY MEDICINAL PRODUCT

Animec 1% Solution for Injection

2 QUALITATIVE AND QUANTITATIVE COMPOSITION

Active Substance:

Ivermectin 1% w/v (10 mg/ml)
For a full list of excipients, see section 6.1.

3 PHARMACEUTICAL FORM

Solution for injection

4 CLINICAL PARTICULARS

4.1 Target Species

Cattle and Pigs

4.2 Indications for use, specifying the target species

Animec Injection is indicated for the effective treatment and control of the following harmful parasites of cattle and
pigs:

Cattle:

Gastro-intestinal roundworms (adult and fourth stage larvae):
Ostertagia spp (including inhibited O. ostertagi),
Haemonchus placei
Trichostrongylus axei
Trichostrongylus colubriformis,
Cooperia spp,
Bunostomum phlebotomum,
Oesophagostomum radiatum,
Strongyloides papillosus (adult),
Nematodirus helvetianus (adult),
N. spathiger (adult),
Toxocara vitulorum,
Trichuris spp. (adult).

Lungworms (adult and fourth stage larvae):
Dictyocaulus viviparus.

Eye worms (adult):
Thelazia spp.

Warbles (parasitic stages):
Hypoderma bovis and H. lineatum.

Mange mites:
Psoroptes bovis,
Sarcoptes scabiei var. bovis.

Sucking lice:
Linognathus vituli,
Haematopinus eurysternus
Solenopotes capillatus.

May also be used as an aid in the control of the mange mite Chorioptes bovis and biting lice (Damalinia bovis), but
complete elimination may not occur.

Persistant activity:
Treatment at the recommended dose rate controls re-infection with Haemonchus placei and Cooperia spp. acquired up to 14 days after treatment, Ostertagia ostertagi and Oesophagostomum radiatum acquired up to 21 days after treatment and Dictyocaulus viviparus acquired up to 28 days after treatment.

To obtain optimal benefit from the persistent activity of Animec injection for grazing animals it is recommended that
calves which are set-stocked in their first grazing season should be treated 3, 8 and 13 weeks after the day of turn-out.

This can protect the animals from parasitic gastro-enteritis and lungworm disease throughout the grazing season,
provided they are set-stocked, all the calves are included in the programme and that no untreated cattle are added to the pasture.

Treated calves should always be monitored according to good husbandry practices.

Pigs:

Gastrointestinal worms (adult and fourth stage larvae):
Ascaris suum,
Hyostrongylus rubidus,
Oesophagostomum spp,
Strongyloides ransomi (adult and somatic larval stage)

Lungworms:
Metastrongylus spp. (adult)

Lice:
Haematopinus suis

Mange mites:
Sarcoptes scabiei var.suis

4.3 Contraindications

Do not use in case of known hypersensitivity to the active ingredient.
Animec Injection for Cattle and Pigs has been formulated specifically for use in those species. It should not be used in
other species as severe adverse reactions, including fatalities in dogs, may occur.
Do not administer by the intravenous or intramuscular route.

4.4 Special warnings for each target species

None.

4.5 Special precautions for use

Special precautions for use in animals
Parasite resistance to any particular class of anthelmintic may develop following frequent, repeated use of an anthelmintic of that class. It is important that the correct dose is given in order to minimise the risk of resistance. To avoid under dosing animals should be grouped according to their body weight and dosed according to the heaviest animal in the group.

Special Precautions to be taken by the Person Administering the Product to Animals
Take care to avoid self administration; the product may cause local irritation and/or pain at the site of injection.

4.6 Adverse reactions (frequency and seriousness)

Cattle:
Transitory discomfort has been observed in some cattle following subcutaneous administration. A low incidence of
soft tissue swelling at the injection site has been observed. These reactions have disappeared without treatment.

Pigs:
Mild and transient pain reactions may be seen in some pigs following subcutaneous injection.
All these reactions disappeared without treatment.

4.7 Use during pregnancy, lactation or lay

Animec Injection for cattle and pigs can be administered to beef cows at any stage of pregnancy or lactation provided
that the milk is not intended for human consumption. It can be used in breeding sows and boars and will not affect
fertility. Animec Injection for cattle and pigs can be given to all ages of animals including young calves and piglets.
Please refer to point 4.11

4.8 Interaction with other medicinal products and other forms of interaction

Animec Injection can be used concurrently without adverse effects with foot and mouth disease vaccine or clostridial
vaccine, given at separate injection sites.

4.9 Amounts to be administered and administration route

Each ml contains 10 mg of ivermectin sufficient to treat 50 kg of bodyweight of cattle, and 33 kg of bodyweight of
pigs.
The injection may be given with any standard automatic on single-dose or hypodermic syringe.
Use of 17 gauge x ½ inch needle is suggested. Replace with a fresh sterile needle after every 10 to 12 animals. Injection of wet or dirty animals is not recommended. If using a single dose hypodermic syringe, use a separate sterile needle to withdraw

Animec Injection from the container.

Cattle:
Animec Injection should be given only by subcutaneous injection at the recommended dosage level of 200 mcg
ivermectin per kg bodyweight under the loose skin in front of, or behind, the shoulder in cattle. This is equivalent to 1
ml per 50 kg bodyweight.

Pigs:
In pigs, the recommended dosage level is 300 mcg ivermectin per kg bodyweight. This is equivalent to 1 ml per 33 kg
bodyweight. The recommended route of administration is by subcutaneous injection into the neck.

Young Pigs:
In young pigs, especially those below 16 kg for which less than 0.5 ml Animec Injection is indicated, dosing accurately
is important. The use of a syringe that can accurately deliver as little as 0.1 ml is recommended.

4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary

Cattle:
Single dose of 4.0 mg ivermectin per kg (20 x the use level) given subcutaneously resulted in ataxia and depression.

Pigs:
A dose of 30 mg ivermectin per kg (100 x the recommended dose of 0.3 mg per kg) injected subcutaneously to pigs
caused lethargy, ataxia, bilateral mydriasis, intermittent tremors, laboured breathing and lateral recumbency.

4.11 Withdrawal Period(s)

Cattle:
Must not be treated within 49 days of slaughter for human consumption.
Not permitted for use in lactating cows producing milk for human consumption. Do not use in non-lactating dairy cows
including pregnant dairy heifers within 60 days of calving.

Pigs:
Must not be treated within 28 days of slaughter for human consumption.

5 PHARMACOLOGICAL or IMMUNOLOGICAL PROPERTIES

Pharmacotherapeutic group:
Endectocide

ATC vet code:
QP54AA01

5.1 Pharmacodynamic properties
Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action.
Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in
invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gammaaminobutyric (GABA).
The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gates
chloride channels, the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels
and they do not readily cross the blood-brain barrier

5.2 Pharmacokinetic properties

Maximum plasma concentration:

Cattle:
At a dose level of 0.2 mg ivermectin per kg a maximum plasma concentration of 35-50 ng/ml is reached in ±2 days and the half-life in plasma is of 2.8 days.
It is also established that ivermectin is carried mainly in the plasma (80%).
This distribution between plasma and blood cell remains relatively constant.

Pig:
During trials carried out at a dose level of 0.3 mg ivermectin per kg bodyweight, peak plasma concentrations were
reached in 3 (±0.5) days and the drug persisted in plasma for up to 28 days.

Excretion: length of time and route

Cattle:
Only about 1 - 2% is excreted in the urine the remainder is excreted in the faeces, approximately 60% of which is
excreted as unaltered drug. The remainder is excreted as metabolites or degradation products.

Pigs:
Biliary excretion is also the major route of ivermectin excretion in pigs.

6 PHARMACEUTICAL PARTICULARS

6.1 List of excipients

Glycerol
Glycerin formal

6.2 Incompatibilities

None known.

6.3 Shelf-life

Shelf life of the veterinary medicinal product as packaged for sale: 3 years.
Following withdrawal of the first dose, use the product within 28 days.

6.4 Special precautions for storage

None.

6.5 Nature and composition of immediate packaging

Multidose polyethylene bottles of 50 ml, 250 ml and 500 ml sealed with bromobutyl seals and aluminium overseals.

6.6 Special precautions for the disposal of unused veterinary medicinal products or waste materials

Extremely dangerous to fish and aquatic life.

Unused product or waste material should be disposed of in accordance with current practice for pharmaceutical waste under national waste disposal regulations.

7 MARKETING AUTHORISATION HOLDER
Chanelle Animal Health Ltd.,
7 Rodney Street,
Liverpool L19 HZ,
United Kingdom.

8 MARKETING AUTHORISATION NUMBER(S)
VPA 10879/14/1

9 DATE OF THE FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION
10th January 2006

10 DATE OF REVISION OF THE TEXT
4th January 2010
 

 Cattle Injectables
Injectables should be given according to the manufacturer’s instructions at the recommended injection site.
• Always use a clean, sterile syringe and needle. If using a multiple injection gun, ensure the needle is disinfected between injections, e.g. with an automatic sterilisation system.
• If the site to be injected is dirty, clean the skin and swab with an alcohol-impregnated wipe or cotton wool.
• Before injecting, check the expiry date and read the instructions of the product to be used. Some products need to be shaken before use.
• Use the correct-sized needle according to the size of the animal and site of injection.
• Ensure the animal is adequately restrained before attempting the injection.
• Take care to ensure it is given subcutaneously and not intramuscularly. Raise a fold of skin at the injection site (mainly neck but some are ear) recommended by the product manufacturer and inject carefully into the space created.
• If a large dose is to be delivered, it may be advisable to split the dose between two injection sites. After the injection, briefly massage the site to improve the dispersal of the injected material.
• Dispose of the needle and syringe in appropriate clinical waste and sharps containers.

Ivermectin is a semi-synthetic antiparasitic medication derived from avermectins, a class of highly active broad-spectrum antiparasitic agents isolated from the fermentation products of Streptomyces avermitilis. 
Ivermectin itself is a mixture of two avermectins, comprising roughly 90% 5-O-demethyl-22,23-dihydroavermectin A1a (22,23-dihydroavermectin B1a) and 10% 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro­-25-(1-methylethyl) avermectin A1a (22,23-dihydroavermectin B1b).

Delivery Information

Delivery Service

Here at Agridirect we have joined forces with DPD to ensure all packages are delivered promptly and safely to you. We ship to all mainland countries within the EU. Deliveries take place Monday to Friday excluding bank holidays. Once your order has been dispatched from our warehouse you will be notified by email. If there is a delay with your order for any reason you will be contacted immediately. 

Due to Brexit we are temporarily unable to ship to the UK. Shipping to Northern Ireland will remain in place.

Delivery Times

Some products have an extended delivery time, this is noted on the products.

Delivery Rates

A selection of the products we sell are only licensed for sale within the Republic Of Ireland and can not be shipped outside of the country. These products are noted as only being available within the Republic of Ireland on the individual product pages.

There may be an addition charge on certain bulky items. This charge will be clearly marked on an applicable products and will be explained on the checkout page before payment has been made.

Agridirect Returns Policy

We’re sorry your purchase didn’t work out. But don’t worry; we have a great returns policy to help you out.

All purchases can be returned to us within 14 days of delivery and returned goods must be received within 14 days from the date you informed us of the return.

Purchases may be opened for inspection but must not be used and must be repackaged securely in the original packaging if you wish to return it.

If we discover goods have been used or there has been a loss in value of the goods due to damage to the goods, while in your care or whilst being returned to us, we will reduce the amount refunded, which may amount to the full cost of the product, to cover loss of value of goods.

All returns should be complete which includes boxes, manuals and accessories that may have been included with the order.

All returns must be packaged appropriately for shipping, we will not accept responsibility for damages or loss which occur during shipping of a return product.

We accept no responsibility for goods damaged or lost while in transit to us. 

How do I return a product?

We have partnered with DPD to make your returns process easy and secure. simply follow the steps below and bring your package to an official DPD pickup point.

1) All returns must be accompanied with a fully filled out returns form which can be downloaded here.

2) To print off your return label click here or visit www.dpd.ie/returns and follow the on-screen instructions. Make sure and use your order number as your reference.

• Select “Continue as Guest”
• Select “Agridirect” from the drop-down menu
• Select your reason for returning
• Select the size of the package you wish to return
• Accept DPD’s terms and conditions
• Fill in your payment details
• Fill in your own details
• Follow the instructions to print off your label

3) Bring your package to a DPD pickup point. To find your nearest drop off point here.

Once the returned product has been received into our warehouse and been fully inspected a refund will be issued.

If you choose not to use the DPD returns service we recommend that you use a method that can be tracked.

For the return of bulk products please contact us at sales@agridirect.ie

I have received a damaged product from you, what should I do?

First off, if you have received a damaged electrical product from us, do not plug it in. Any electrical products that are plugged in are deemed ‘as used and accepted’ and are not accepted as returns. All damages must be reported to us via phone or email within 24hours of receipt of goods. Please ensure you check your items upon delivery.

How do I begin the returns process?

If you wish to begin the return process, please email us at sales@agridirect.ie and ensure the following information is included in your email. Your name, phone number, Order id, the item you wish to return, reason for return and if the product is damaged we require photos of the product.

Once you have sent us all required information a member of our team will assess your claim and will contact you as soon as possible. Please hold off on returning products until a member of our team has called you to confirm.

Refunds

Once the returned product has been returned to us and fully inspected a refund will be issued.

Please Note: A typical timeline for a refund to show in your account is up to 10 working days from the date processed, depending on your bank.