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Vecoxan (diclazuril, methyl parahydroxybenzoate, propyl parahydroxybenzoate)
Vecoxan (diclazuril, methyl parahydroxybenzoate, propyl parahydroxybenzoate)
Vecoxan (diclazuril, methyl parahydroxybenzoate, propyl parahydroxybenzoate)
Vecoxan (diclazuril, methyl parahydroxybenzoate, propyl parahydroxybenzoate)

Vecoxan (diclazuril, methyl parahydroxybenzoate, propyl parahydroxybenzoate)

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Vecoxan is a white Oral Suspension for lambs and calves which has been created to prevent scours caused by coccidiosis.  
In lambs Vecoxan is used for the prevention of coccidiosis caused by Eimeria crandallis and Eimeria ovinoidalis.
In calves Vecoxan is used for the prevention of coccidiosis caused by Eimeria bovis and Eimeria zuernii.
The easy to use drench comes in a bottle supplied with harness and spouted cap.

Each ml contains: 
diclazuril 2.5mg, 
methyl parahydroxybenzoate (E218) 1.8mg, 
propyl parahydroxybenzoate (E216) 0.2mg.

What is coccidiosis?

Coccidiosis is a highly contagious disease that normally infects calves between one and six months of age but can also infect older cattle as well. 
Coccidiosis is caused by a single celled microscopic parasite that multiplies in the intestine of infected animals, the eggs are then passed through faeces onto the soil and grass where they are eaten by other animals which then become infected. 
Coccidiosis is still one of the most common and costly diseases a farmer can face on his farm.

What are the symptoms of Coccidiosis?

Common symptoms of Coccidiosis are diarrhoea, rough coat, loss of appetite, loss of weight and weakness in calves. In severe cases there will be blood and mucus present in the animals manure and if left untreated will lead to the animal's death.

Active ingredient

Diclazuril 2.5 mg

Target Species

Calves and Lambs

Treats and Controls

Prevention of scours caused by coccidiosis.  

Application Method for Vecoxan

A single oral administration. 

 

Withdrawal Period for Vecoxan

Vecoxan has a zero day withdrawal for both lambs and Calves

Dose rates for Vecoxan

1 mg diclazuril per kg body weight (i.e 1 ml of the oral suspension per 2.5 kg body weight), in a single oral administration for both lambs and calves. Read the package leaflet before use.

Key Features of Vecoxan

  • Prevention of Coccidosis
  • For use on both calves and lambs
  • Easy to use 

This Product is only licensed for sale in the Republic of Ireland

Click here to Download Data Sheet

Health Products Regulatory Authority

Summary of Product Characteristics

1 NAME OF THE VETERINARY MEDICINAL PRODUCT
Vecoxan 2.5 mg/ml Oral Suspension for lambs and calves

2 QUALITATIVE AND QUANTITATIVE COMPOSITION
Each ml contains:
Active substance:
Diclazuril 2.5 mg

Excipients:
Methyl parahydroxybenzoate (E218) 1.8 mg
Propyl parahydroxybenzoate 0.2 mg
For a full list of excipients see 6.1

3 PHARMACEUTICAL FORM
White, oral suspension.

4 CLINICAL PARTICULARS
4.1 Target Species

Ovine (lambs) and bovine (calves).

4.2 Indications for use, specifying the target species
In lambs: Prevention of coccidiosis caused by Eimeria crandallis and Eimeria ovinoidalis.
In calves: Prevention of coccidiosis caused by Eimeria bovis and Eimeria zuernii.
If there is no recent and confirmed history of clinical coccidiosis, the presence of coccidia in the flock or herd should be confirmed by faecal sampling prior to treatment.

4.3 Contraindications
Do not use in cases of hypersensitivity to the active substance or to any of the excipients.

4.4 Special warnings for each target species
Avoid underdosing which may be due to underestimation of body weight, misadministration of the product or lack of calibration of the dosing device (if any).
Calves: in certain cases, only a transient reduction of oocyst shedding may be achieved.
Suspected clinical cases of resistance to anticoccidials should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test).
Where the results of the test(s) strongly suggest resistance to a particular antiprotozoal, an anticoccidial belonging to another pharmacological class and having a different mode of action should be used.

4.5 Special precautions for use
Special precautions for use in animals

The preferred timing of treatment is directed by the known epidemiology of Eimeria spp. and the presence of coccidia in the flock or herd should be confirmed by faecal sampling prior to treatment, if there is no recent and confirmed history of clinical coccidiosis. 
Coccidiosis is an indicator of insufficient hygiene in the flock/pen.
It is recommended to improve hygiene and to treat all lambs in the flock and all calves in a pen.
Frequent and repeated use of antiprotozoals may lead to the development of resistance in the target parasite.
To alter the course of an established clinical coccidial infection, in individual animals already showing signs of diarrhoea, additional supportive therapy may be required as diclazuril has no antimicrobial activity.
Special precautions to be taken by the person administering the veterinary medicinal product to animals Wash hands after administration of the product.

4.6 Adverse reactions (frequency and seriousness)
In very rare cases, adverse events involving gastrointestinal disorders (such as diarrhoea, with possible presence of blood), lethargy and/or neurological troubles (agitation, recumbency, paresis...) have been reported.
Some treated animals may show signs of clinical disease (diarrhoea) even though oocyst excretion is reduced to a very low level.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals displaying adverse reaction(s) during the course of one treatment)
- common (more than 1 but less than 10 animals in 100 animals)
- uncommon (more than 1 but less than 10 animals in 1,000 animals)
- rare (more than 1 but less than 10 animals in 10,000 animals)
- very rare (less than 1 animal in 10,000 animals, including isolated reports).

4.7 Use during pregnancy, lactation or lay
Not applicable.

4.8 Interaction with other medicinal products and other forms of interactions
None known.

4.9 Amounts to be administered and administration route
Shake well before use.
To ensure a correct dosage, body weight should be determined as accurately as possible.
If animals are to be treated collectively rather than individually, they should be grouped according to their body weight and dosed accordingly, in order to avoid under- or overdosing.
1 mg diclazuril per kg body weight (i.e. 1 ml of the oral suspension per 2.5 kg body weight), in a single oral administration. 

4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
In lambs: no signs of overdose were noted after administration of 5 times the recommended dose.
In calves: no signs of overdose were noted after a single administration of 5 times the recommended dose.
In case of repeated administration of 3 to 5 times the dose, on 3 consecutive days, a softening and a colour change (dark brown) of the faeces can be observed in some calves.
These observations were transient and disappeared without specific treatment.

4.11 Withdrawal period(s)
Meat and offal:
Lambs: zero days
Calves: zero days 

5 PHARMACOLOGICAL or IMMUNOLOGICAL PROPERTIES Pharmacotherapeutic group:
Antiprotozoals, Triazines

ATCVet Code:
QP51AJ03

5.1 Pharmacodynamic properties
Diclazuril is an anticoccidial of the benzeneacetonitrile group and has anticoccidial activity against Eimeria species. Depending on the coccidia species, diclazuril has a coccidiocidal effect on the asexual or sexual stages of the development cycle of the parasite.
Diclazuril treatment will only have limited effect on the intestinal lesions caused by parasitic stages older than 16 days.
Treatment with diclazuril causes interruption of the coccidial cycle and of excretion of oocysts for approximately 2 weeks.
This allows the animal to bridge the period of decrease of maternal immunity (observed at approximately 4 weeks of age).

5.2 Pharmacokinetic particulars
The absorption of diclazuril in lambs is poor after administration of the oral suspension.
Maximum concentrations in plasma are reached about 24 hours after dosing.
The absorption decreases with the animals’ age.
The elimination half-life is about 30 hours.
In-vitro studies on sheep hepatocytes demonstrated that metabolic transformation of diclazuril is limited.
This was equally observed in other animal species.
Excretion occurs almost completely via the faeces.
When diclazuril is administered in oral suspension to calves, its absorption is poor.

6 PHARMACEUTICAL PARTICULARS
6.1 List of excipients

Methyl parahydroxybenzoate (E218)
Propyl parahydroxybenzoate
Microcrystalline cellulose (E460)
Carboxymethylcellulose sodium (E466)
Citric acid monohydrate (E330)
Polysorbate 20 (E432)
Sodium hydroxide (E524)
Purified water

6.2 Major incompatibilities
None known.

6.3 Shelf-life
Shelf-life of the veterinary medicinal product as packaged for sale: 3 years
Shelf-life after first opening the immediate packaging: 3 months

6.4 Special precautions for storage
Do not freeze.

6.5 Nature and composition of immediate packaging
Nature of the container High density polyethylene bottle
High density polyethylene dosing cap
Commercial packs Box with 200 ml container with harness and spouted cap
Box with 1 litre container with harness and spouted cap
Box with 2.5 litre container with harness and spouted cap
Box with 5 litre container with harness and spouted cap

Not all pack sizes may be marketed.

6.6 Special precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products
Any unused veterinary medicinal product or waste material derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

7 MARKETING AUTHORISATION HOLDER
Intervet Ireland Limited
Magna Drive
Magna Business Park,
Citywest Road
Dublin 24
Ireland

8 MARKETING AUTHORISATION NUMBER(S)
VPA10996/285/001

9 DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION
Date of first authorisation: 04 February 2000
Date of last renewal: 24 October 2008

10 DATE OF REVISION OF THE TEXT
November 2020

Drench correctly
Sheep Oral Drench

The drenching technique is a vital part of ensuring that the wormer does its job effectively.
Make sure the sheep are properly restrained and cannot leap around when they are being drenched so they swallow the whole amount.
Sheep can also suffer serious injury, or even death, if they are unrestrained and the gun penetrates the tissues at the back of the mouth.
Place a hand under the head and tilt slightly to the side.
Slot the nozzle in the gap between molar and incisor teeth and then over the back of the tongue.
If the wormer is just put into the mouth, it will bypass the rumen as it escapes down the oesophageal groove and will be less effective.
This is particularly important for white (BZ) drenches.

Dosing Weigh – do not guess Underestimating the weight of sheep is a common cause of underdosing. Select and weigh the biggest sheep in the group to determine the correct dose. If there is a wide range of weights, consider splitting the group, then weigh the heaviest in each section. Do not forget to check that the weigh crate is accurate before starting!

Calibrate and maintain the drench gun
Always check the gun is delivering the right amount before you drench. Remove the plunger from a 10 ml syringe, put a thumb over the end and squirt the dose into it, making sure there are no air bubbles left. Adjust the gun until the dose delivered is correct. Drenching guns should also be well maintained and replaced regularly. Clean with warm soapy water after use and check springs and tubes to make sure there are no kinks that will form air bubbles.

Withholding food
Research has shown that the efficacy of the white (BZ) and clear (AV) drenches can be improved by withholding food for 12–24 hours before treatment. It is not advised to deprive heavily pregnant ewes of food, so if you treat this class of stock with anthelmintics, you may wish to use yellow drenches (LV) because their efficacy is less dependent on rumen fill.

Storage
Wormers should be stored securely, away from direct sunlight at 4–25°C. Check the use-by date and, once open, use within the time shown on the packaging. Shake white (BZ) products well before use.

 Cattle Oral drenches
Oral drenching guns are designed to deliver the treatment towards the back of the mouth over the tongue, so the entire dose is swallowed at once to optimise efficacy.
• Make sure animals are properly restrained, with their head held up
• Slide the nozzle of the dosing gun in the side of the mouth and over the tongue so that the entire dose is swallowed immediately
• Drenching equipment must be correctly calibrated and in good working order
• Calibrate the gun using the product just before treatment starts by delivering two or more doses into a graduated measuring cylinder. 
Faulty equipment, or attempting to dose too quickly, may mean that the barrel of the gun does not fill properly or that the liquid is full of bubbles.

Delivery Information

Delivery Service

Here at Agridirect we have joined forces with DPD to ensure all packages are delivered promptly and safely to you. We ship to all mainland countries within the EU. Deliveries take place Monday to Friday excluding bank holidays. Once your order has been dispatched from our warehouse you will be notified by email. If there is a delay with your order for any reason you will be contacted immediately. 

Due to Brexit we are temporarily unable to ship to the UK. Shipping to Northern Ireland will remain in place.

Delivery Times
Ireland (ROI & NI)EU (Mainland Only)
2-4 Working Days4-6 Working Days

Some product have an extended delivery time, this is noted on the products.

Delivery Rates

CountryOrders Under €99Orders Over €99
Ireland (ROI & NI)€6.99€0.00
Austria€19.99€13.00
Belgium€16.99€10.00
Czech Republic€19.99€13.00
Denmark€19.99€13.00
Finland€31.99€25.00
France€16.99€10.00
Germany€16.99€10.00
Hungary€23.99€17.00
Italy€29.99€23.00
Luxenburg€16.99€10.00
Netherlands€16.99€10.00
Poland€16.99€13.00
Portugal€31.99€25.00
Slovakia€23.99€17.00
Slovenia€23.99€17.00
Spain€29.99€23.00
Sweden€29.99€23.00

 

A selection of the products we sell are only licensed for sale within the Republic Of Ireland and can not be shipped outside of the country. These products are noted as only being available within the Republic of Ireland on the individual product pages.

There may be an addition charge on certain bulky items. This charge will be clearly marked on an applicable products and will be explained on the checkout page before payment has been made.

Agridirect Returns Policy

We’re sorry your purchase didn’t work out. But don’t worry; we have a great returns policy to help you out, plus returns are free.

All purchases can be returned to us within 14 days of delivery and returned goods must be received within 14 days from the date you informed us of the return.

Purchases may be opened for inspection but must not be used and must be repackaged securely in the original packaging if you wish to return it.
 

If we discover goods have been used or there has been a loss in value of the goods due to damage to the goods, while in your care or whilst being returned to us, we will reduce the amount refunded, which may amount to the full cost of the product, to cover loss of value of goods.

All returns should be complete which includes boxes, manuals and accessories that may have been included with the order.

All returns must be packaged appropriately for shipping, we will not accept responsibility for damages or loss which occur during shipping of a return product.

We accept no responsibility for goods damaged or lost while in transit to us. 

How do I return a product?

Making returns to us are free, simply follow the steps below and bring your package to an official DPD pickup point.

  • All returns must be accompanied with a fully filled out returns form which can be downloaded here.
  • To print off your return label click here or visit www.dpd.ie/returns and follow the on-screen instructions. Make sure and use your order number as your reference.
  • Bring your package to a DPD pickup point. To find your nearest drop off point here.

Once the returned product has been received into our warehouse and been fully inspected a refund will be issued.

For the return of bulk products please contact us at sales@agridirect.ie

I have received a damaged product from you, what should I do?

First off, if you have received a damaged electrical product from us, do not plug it in. Any electrical products that are plugged in are deemed ‘as used and accepted’ and are not accepted as returns. All damages must be reported to us via phone or email within 24hours of receipt of goods. Please ensure you check your items upon delivery.

How do I begin the returns process?

If you wish to begin the return process, please email us at sales@agridirect.ie and ensure the following information is included in your email. Your name, phone number, Order id, the item you wish to return, reason for return and if the product is damaged we require photos of the product.

Once you have sent us all required information a member of our team will assess your claim and will contact you as soon as possible. Please hold off on returning products until a member of our team has called you to confirm.

Refunds

Once the returned product has been returned to us and fully inspected a refund will be issued.

Please Note: A typical timeline for a refund to show in your account is up to 10 working days from the date processed, depending on your bank.

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