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Levafas Diamond (Levamisole hyrochloride, Oxyclozanide)
Levafas Diamond (Levamisole hyrochloride, Oxyclozanide)
Levafas Diamond (Levamisole hyrochloride, Oxyclozanide)

Levafas Diamond (Levamisole hyrochloride, Oxyclozanide)

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Levafas Diamond fluke and worm drench for sheep and cattle is a broad spectrum anthelmintic that is used as an oral drench in the treatment and control of gastro-intestinal and pulmonary roundworm infections and adult liver fluke infections. The active ingredient in Levafas Diamond is Levamisole hydrochloride. Levamisole is highly effective in the treatment of mature and developing immature stages of a wide range of important roundworm species in sheep and cattle.

Active Ingredient: Levamisole hyrochloride, Oxyclozanide

Target Species: Cattle, sheep

Treats and Controls: Liver fluke, roundworms

Administration Method: Oral drench

Withdrawal Time: 28 days for cattle intended for meat and offal,not permitted for use on cattle producing milk for human consumption. 10 days for sheep intended for meat and offal, not permitted for use on sheep producing milk for human consumption.

Dosage for cattle: 12.5 ml per 50 kg of bodyweight

Dosage rates for cattle
Body WeightDose VolumeNumber of full doses per pack:
1 Litre2.5 Litre4 Litre
50kg12.5 ml80200320
100kg25.0 ml40100160
150kg37.5 ml2666106
200kg50.0 ml205080
250kg62.5 ml164064
300kg75.0 ml133353
350kg87.5 ml112845
400kg100 ml102540
450kg112.5 ml82235
500kg125.0 ml82032
550kg137.5 ml71829
600kg150.0 ml61626

Dosage for sheep: 2.5ml per 10kg Bodyweight

Dosage rates for sheep
Body WeightDose VolumeNumber of full doses per pack:
1 Litre2.5 Litre4 Litre
10kg2.5 ml40010001600
20kg5.0 ml200500800
30kg7.5 ml133333532
40kg10.0 ml100250400
50kg12.5 ml80200320
60kg15.0 ml66166264
70kg17.5 ml57142228

Always read the label and all enclosed information for Levafas Diamond before administering to animals!

What is the financial cost of fluke infections?

According to "Liver Fluke - the Facts", a paper published by Animal Health Ireland (AHI), liver fluke costs the worldwide livestock and food industries an estimated €2.5 million per year. These financial losses associated with liver fluke are mainly due to a reduction in the amount of milk and meat produced. Liver fluke can cause a loss of up to 20% in cattle, 30% in sheep and a loss of up to 8% in the milk production of dairy cows.

Animals become infected with liver fluke by ingesting encapsulated Larvae (metacercariae). These larvae are picked up when the animal grazes on contaminated grass. It is very common that farms have a wet and "flukey" area that shouldn't be used for grazing at times of year when the metacercariae are present. Nonetheless, cattle and sheep still graze on these areas so we must accept that liver fluke is still a problem in the livestock industry.

What are the signs and effects of livestock infected with other parasites?

Signs and effects of infected livestock

Infection: Gut Worm

Symptoms: Diarrhoea, decreased appetite, loss of weight

Effects: Gutworm can cause severe damage to the stomach and small intestine which will cause parasitic gastroenteritis, this will not only negatively affect the health of the animal but will affect the profitability for the farmer.

Infection: Lungworm

Symptoms: Short, sharp cough that becomes worse with exercise, in severe cases the animal will have obvious difficulty breathing.

Effects: Lungworm infections cause a high susceptibility to respiratory viruses and bacteria. Infected cattle are prone to contracting severe bronchial pneumonia which if left untreated can lead to death.

Features of Levafas Diamond 

  • Fluke and worm drench for sheep and cattle
  • A broad spectrum anthelmintic that is used as an oral drench
  • Treats and controls of gastro-intestinal and pulmonary roundworm infections and adult liver fluke infections.
  • Active ingredient is Levamisole hydrochloride.
  • Highly effective in the treatment of mature and developing immature roundworm species in sheep and cattle.

​This product is only licensed for sale within the Republic of Ireland

Data Sheet

1 NAME OF THE VETERINARY MEDICINAL PRODUCT
Levafas Diamond Fluke and Worm Drench

2 QUALITATIVE AND QUANTITATIVE COMPOSITION
Active Substances
Levamisole hydrochloride 3.0 % w/v
Oxyclozanide 6.0 % w/v
Excipients
Sodium metabisulphite (E223) 0.15 % w/v
Tartrazine (E102) 0.011 % w/v
Sodium methyl parahydroxybenzoate (E219) 0.18 % w/v

3 PHARMACEUTICAL FORM
Oral suspension.
A yellow viscous suspension.

4 CLINICAL PARTICULARS
4.1 Target Species
Cattle, sheep.
Active Substances
Levamisole hydrochloride 3.0 % w/v
Oxyclozanide 6.0 % w/v
Excipients
Sodium metabisulphite (E223) 0.15 % w/v
Tartrazine (E102) 0.011 % w/v
Sodium methyl parahydroxybenzoate (E219) 0.18 % w/v

4.2 Indications for use, specifying the target species
For the treatment and control of both gastro-intestinal and pulmonary nematode infections and adult liver fluke
infections in cattle and sheep. Levafas Diamond Fluke and Worm Drench should be used in cases of parasitic
gastroenteritis and lungworm caused by those organisms sensitive to treatment with Levamisole hydrochloride.
Levamisole is effective against mature and developing immature stages of a wide range of important nematode species
and is highly effective against the following:
Lungworms:
Dictyocaulus spp.
Gastrointestinal worms:
Trichostrongyles spp.
Cooperia spp.
Ostertagia spp. (except inhibited Ostertagia larvae)
Haemonchus spp.
Nematodirus spp.
Bunostomum spp.
Oesophagostomum spp.
Chabertia spp.
Levafas Diamond Fluke & Worm Drench also removes most mature Fasciola spp. (flukes) present in the bile ducts of
the liver.

4.3 Contraindications
Do not use in animals known to be hypersensitive to the active substances

4.4 Special warnings for each target species
Care should be taken when treating heavily pregnant animals or animals under stress from adverse weather conditions,
poor nutrition, penning, handling, etc.. Levafas Diamond Fluke and Worm Drench is not effective against Type II
Ostertagiasis (winter scours) in cattle. In cases of lungworm infections, coughing may persist for a considerable time
following successful treatment with Levafas Diamond Fluke and Worm Drench. This is due to tissue damage caused
by the parasites.
Care should be taken to avoid the following practices because they increase the risk of development of resistance and
could ultimately result in ineffective therapy:
- Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
- Underdosing which may be due to underestimation of bodyweight, misadministration of the product, or lack of
calibration of the dosing device.
Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal
Egg Count Reduction Test). Where the results of the tests strongly suggest resistance to a particular anthelmintic, an
anthelmintic belonging to another pharmacological class and having a different mode of action should be used.

4.5 Special precautions for use
Special precautions for use in animals
When using a dosing gun to administer this product, care must be taken to avoid dosing gun pharyngitis. After
treatment, animals should be moved to clean pasture in order to prevent re-infection. Where this is not done, further
dosing at 10-14 day intervals may be necessary.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
When using, do not eat, drink or smoke.
Wash splashes from eyes and skin immediately.
Take off immediately any contaminated clothing.
Wash hands and exposed skin before meals and after work.
Levamisole can cause idiosyncratic reactions and serious blood disorders in a very small number of people. If
symptoms such as dizziness, nausea, vomiting or abdominal discomfort are experienced when using the product, or
sore mouth/throat or fever occur shortly afterwards, then medical advice should be sought immediately.

4.6 Adverse reactions (frequency and seriousness)
At normal oxyclozanide dose levels, cattle may show slight softening of the faeces with the occasional animal showing
increased frequency of defecation and transient inappetance.

4.7 Use during pregnancy, lactation or lay
The product can be safely administered to pregnant or lactating animals.

4.8 Interaction with other medicinal products and other forms of interaction
Concurrent treatment with products containing organophosphorus compounds or diethylcarbamazine citrate should be
avoided. These compounds should not be administered within a period of 14 days before or after treatment with
Levafas Diamond Fluke and Worm Drench.

4.9 Amounts to be administered and administration route
To ensure administration of a correct dose, bodyweight should be determined as accurately as possible; accuracy of the
dosing device should be checked. If animals are to be treated collectively rather than individually, they should be
grouped according to their bodyweight and dosed accordingly, in order to avoid under- or overdosing.
Levafas Diamond Fluke and Worm Drench should be administered as an oral drench.
Dosing may be carried out using a drenching bottle or a suitable gun system, at a rate of 7.5 mg levamisole
hydrochloride/kg bodyweight and 15 mg oxyclozanide/kg bodyweight achieved by administering 25 ml per 100 kg
bodyweight in cattle and 2.5 ml per 10 kg bodyweight in sheep.
The veterinary surgeon should give advice regarding appropriate dosing programmes and stock management to achieve
adequate parasite control.

4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
If recommended dosages are exceeded animals may exhibit signs of overdosage. The effects of levamisole overdosage
include impaired motor function i.e. muscle tremors, head shaking and increased salivation. These effects are transient
and more likely to be found in cattle than in sheep. The effects of oxyclozanide overdosage are dullness and some
loosening of faeces in sheep and possible diarrhoea, inappetence and loss of weight in cattle. The effects are
occasionally enhanced in animals with severe liver damage and/or dehydration at the time of dosing.

4.11Withdrawal Period(s)
Animals must not be slaughtered for human consumption during treatment.
Cattle may be slaughtered for human consumption only after 28 days from the last treatment.
Sheep may be slaughtered for human consumption only after 10 days from the last treatment.
Do not use in animals producing milk for human consumption.

5 PHARMACOLOGICAL or IMMUNOLOGICAL PROPERTIES
Pharmacotherapeutic group: Anthelmintics, levamisole, combinations
ATCvet code: QP52AE51

5.1 Pharmacodynamic properties
Levamisole is an imidazothiazole that acts by interfering with parasite nerve transmission causing muscular paralysis.
It is effective against adult and immature gastro-intestinal roundworm and lungworm infections. Oxyclozanide is a
salicylanilide which is mainly active against adult liver flukes. It is distributed to the liver, kidney and intestines and is
excreted in the bile.

6 PHARMACEUTICAL PARTICULARS
6.1 List of excipients
Sodium citrate
Anhydrous citric acid
Sodium metabisulphite (E223)
Disodium edetate
Polysorbate 80
Xanthan gum
Tartrazine (E102)
Sodium methyl parahydroxybenzoate (E219)
Antifoam M30
Purified water

6.2 Incompatibilities
None known.

6.3 Shelf-life
Shelf-life of the veterinary medicinal product as packaged for sale: 2 years.

6.4 Special precautions for storage
Do not store above 25°C.
Protect from light.

6.5 Nature and composition of immediate packaging
Low density polyethylene containers of 1 litre, 2.5 litres, 4 litres and 10 litres.
Not all pack sizes may be marketed.

6.6 Special precautions for the disposal of unused veterinary medicinal products or waste materials
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be
disposed of in accordance with local requirements.

7 MARKETING AUTHORISATION HOLDER
Norbrook Laboratories Limited
Station Works
Newry, BT35 6JP
Co. Down
Northern Ireland

8 MARKETING AUTHORISATION NUMBER(S)
VPA 10999/036/001

9 DATE OF THE FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION
30th September 2009

Delivery

 

Delivery Information

Here at Agridirect we have joined forces with DPD to ensure all packages are delivered promptly and safely to you. We ship to all mainland countries within the EU. Deliveries take place Monday to Friday excluding bank holidays. Once your order has been dispatched from our warehouse you will be notified by email. If there is a delay with your order for any reason you will be contacted immediately. 

Delivery Times
Ireland (ROI & NI)United Kingdom (Mainland Only)EU (Mainland Only)
1-3 Working Days2-4 Working Days4-6 Working Days

Some product have an extended delivery time, this is noted on the products.

Delivery Rates

Delivery Rates
CountryOrders Under €70Orders Over €70
Ireland (ROI & NI)€4.99€0.00
Austria€17.99€13.00
Belgium€14.99€10.00
Czech Republic€17.99€13.00
Denmark€17.99€13.00
Finland€29.99€25.00
France€14.99€10.00
Germany€14.99€10.00
Hungary€21.99€17.00
Italy€27.99€23.00
Luxenburg€14.99€10.00
Netherlands€14.99€10.00
Poland€14.99€13.00
Portugal€29.99€25.00
Slovakia€21.99€17.00
Slovenia€21.99€17.00
Spain€27.99€23.00
Sweden€27.99€23.00
United Kingdom (Mainland Only)€14.99€10.00

 

 

A selection of the products we sell are only licensed for sale within the Republic Of Ireland and can not be shipped outside of the country. These products are noted as only being available within the Republic of Ireland on the individual product pages

There may be an addition charge on certain bulky items. This charge will be clearly marked on an applicable products and will be explained on the checkout page before payment has been made.

 

Returns

Returns Policy

We’re sorry your purchase didn’t work out. But don’t worry; we have a great returns policy to help you out.
 

All purchases can be returned to us within 14 days of delivery and returned goods must be received within 14 days from the date you informed us of the return.
 

Purchases may be opened for inspection but must not be used and must be repackaged securely in the original packaging if you wish to return it.
 

If we discover goods have been used or there has been a loss in value of the goods due to damage to the goods, while in your care or whilst being returned to us, we will reduce the amount refunded, which may amount to the full cost of the product, to cover loss of value of goods.
 

We accept no responsibility for goods damaged or lost while in transit to us. 
 

The cost of the return, including all packaging and freight, lies solely with the consumer.
 

I have received a damaged product from you, what should I do?

First off, if you have received a damaged electrical product from us, do not plug it in. Any electrical products that are plugged in are deemed ‘as used and accepted’ and are not accepted as returns. All damages must be reported to us via phone or email within 24hours of receipt of goods. Please ensure you check your items upon delivery.

How do I begin the returns process?

If you wish to begin the return process, please email us at sales@agridirect.ie and ensure the following information is included in your email. Your name, phone number, Order id, the item you wish to return, reason for return and if the product is damaged we require photos of the product.

Once you have sent us all required information a member of our team will assess your claim and will contact you as soon as possible. Please hold off on returning products until a member of our team has called you to confirm.

 

Packaging

All returns must be the complete product which includes boxes, manuals and accessories that may have been include with the order.

All returns must be packaged appropriately for shipping, we will not accept responsibility for damages or loss which occur during shipping of a return product.
 

Address: Please ship the product to the following address: Agridirect, Drumrahan Retail, Church Street, Ballyconnell, Co Cavan
 

Refunds

Once the returned product has been returned to us and fully inspected a refund will be issued.

Please Note: A typical timeline for a refund to show in your account is up to 10 working days from the date processed, depending on your bank.

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