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Imec Pour On (Ivermectin)
Imec Pour On (Ivermectin)
Imec Pour On (Ivermectin)
Imec Pour On (Ivermectin)
Imec Pour On (Ivermectin)

Imec Pour On (Ivermectin)

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Imec Pour-on for Cattle 5 mg/ml is used for the treatment and control of gastro-intestinal nemotades, lungworms, warbles, chotioptic and sarcoptic mange mites and sucking and biting lice of beef and non-lactating dairy cattle.

Active Ingredient:Ivermectin

Target Species: Cattle

Administration Method: Pour-on

Treats and Controls: Gastro-intestinal roundworms, lungworms, eyeworms, mites and lice

Withdrawal Time: 31 days for animals intended for meat and offal, not permitted for use on animals producing milk for human consumption.

Dosage: 1 ml per 10 kg of bodyweight

Body WeightDose VolumeNumber of full doses per pack:
1 Litre2.5 Litre5 Liter
50kg5 ml2005001000
100kg10 ml100250500
150kg15 ml67167333
200kg20 ml50125250
250kg25 ml40100200
300kg30 ml3383167
350kg35 ml2971143
400kg40 ml2563125
450kg45 ml2256111
500kg50 ml2050100
550kg55 ml184591
600kg60 ml174183

Always read the label and all enclosed information for Imec Pour-on before administering to animals!

What are the signs and effects of livestock infected with parasites?

 

Signs and effects of infected livestock

Infection:Gut Worm

Symptoms: Diarrhoea, decreased appetite, loss of weight

Effects: Gutworm can cause severe damage to the stomach and small intestine which will cause parasitic gastroenteritis, this will not only negatively affect the health of the animal but will affect the profitability for the farmer.

Infection: Lungworm

Symptoms:Short, sharp cough that becomes worse with exercise, in severe cases the animal will have obvious difficulty breathing.

Effects:Lungworm infections cause a high susceptibility to respiratory viruses and bacteria. Infected cattle are prone to contracting severe bronchial pneumonia which if left untreated can lead to death.

 

Key Features of Imec Injection

  • Broad spectrum Ivermectin Pour on
  • Aimed at treating cattle
  • Treatment of most parisites both internal and external

 

Click here to Download Data Sheet

Health Products Regulatory Authority 

Summary of Product Characteristics

1 NAME OF THE VETERINARY MEDICINAL PRODUCT

Imec 5 mg/ml pour-on solution for cattle

2 QUALITATIVE AND QUANTITATIVE COMPOSITION

1 ml contains:

Active substance(s):

Ivermectin 5 mg

Excipient(s):

Benzyl alcohol (E1519)  10 mg

For a full list of excipients, see section 6.1

3 PHARMACEUTICAL FORM

Pour-on solution.
A clear, colourless solution.

4 CLINICAL PARTICULARS

4.1 Target Species

Cattle.

4.2 Indications for use, specifying the target species

In cattle:
For the treatment of infections with the following parasites

Gastro-intestinal worms
- Haemonchus placei (adult and L4)
Ostertagia ostertagi (adult and L4, including inhibited larvae)
Trichostrongylus axei (adult and L4)
Trichostrongylus colubriformis (adult and L4)
Cooperia punctata (adult only)
Cooperia oncophora (adult only)
Strongyloides papillosus (adult only)
Oesophagostomum radiatum, (adult and L4)

Lungworm (adult and L4)–
Dictyocaulus viviparus.

Warbles (parasitic stages) –
Hypoderma bovis,
Hypoderma lineatum.

Mange mites
Sarcoptes scabiei var. bovis.

The product may also be used to reduce infection of the mange mite Chorioptes bovis, but complete elimination may not occur.

Sucking and biting lice
Linognathus vituli,
Haematopinus eurysternus,
Bovicola (Damalinia) bovis.

The product has persistent activity against infections acquired with Trichostrongylus axei and Cooperia spp. up to 14 days after treatment, but only in the case of group treatment;
Ostertagia ostertagi and Oesophagostomum radiatum up to 21 days after treatment;
Dictyocaulus viviparus up to 28 days after treatment.
It also has persistent activity against horn flies (Haematobia irritans) for up to 28 days after treatment;
partial efficacy against Haematobia irritans may last for up to 35 days post application. 

4.3 Contraindications

Do not use in cases of known hypersensitivity to the active ingredient.
The product has been formulated for topical application specifically for cattle.
It should not be administered to other species as severe adverse reactions including fatalities in dogs, may occur.

4.4 Special warnings for each target species

Do not treat cattle when their hide is wet.
Do not treat cattle if rain is expected, as rain within 2 hours of treatment may reduce efficacy.
Do not apply to areas of skin which have mange scabs or other lesions, or to areas contaminated with mud or manure.

Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:
-Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
-Underdosing, which may be due to underestimation of body weight, misadministration of the product, or lack of calibration of the dosing device.

Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.
Resistance to ivermectin has been reported in Ostertagia ostertagi in cattle. Therefore, the use of this product should be based on local (regional, farm) epidemiological information about susceptibility of this helminth species and recommendations on how to limit further selection for resistance to anthelmintics.

4.5 Special precautions for use Special precautions for use in animals

To avoid secondary reactions due to the death of Hypoderma larvae in the oesophagus or in the spine, it is recommended to administer the product at the end of warble fly activity and before the larvae reach their resting sites. Cases of intolerance with fatal outcome are reported in dogs, especially Collies, old English Sheepdogs and related breeds or crosses, and also in turtles/tortoises.
Do not allow these species to come in contact with this product.
It is recommended to treat all animals within a herd or group.
The shedding of nematode eggs can continue for some time after treatment.
Close container after use.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

May be irritating to human skin and eyes and the user should be careful not to apply it to himself or other persons. Operators should wear rubber gloves, boots, goggles and a waterproof coat when applying the product.
Protective clothing should be washed after use.
As absorption through skin can occur, in the event of accidental skin contact, wash the affected area immediately with soap and water.
If accidental eye exposure occurs, flush the eyes immediately with water and get medical attention.
Do not smoke, eat or drink while handling the product.
Wash hands after use.
Use only in well ventilated areas or outdoors.

HIGHLY INFLAMMABLE, keep away from heat, sparks, open flame or other sources of ignition.

4.6 Adverse reactions (frequency and seriousness)

None known.

4.7 Use during pregnancy, lactation or lay

Studies in laboratory animals have shown neither embryotoxic nor teratogenic effects with ivermectin. Can be used during pregnancy and lactation provided that the milk is not intended for human consumption. Please also see section 4.11

4.8 Interaction with other medicinal products and other forms of interactions

Do not combine ivermectin treatment with vaccination against lungworms.
If vaccinated animals are to be treated, treatment should not be carried out within a period of 28 days before or after vaccination.

4.9 Amounts to be administered and administration route

To ensure administration of a correct dose, body weight should be determined as accurately as possible. If animals are to be treated collectively rather than individually they should be grouped according to their bodyweight and dosed accordingly, in order to avoid under- or over- dosing.

Dosage 1 ml per 10 kg body weight (based on a recommended dosage level of 500 micrograms per kg body weight).

Administration
For topical application.
The formulation should be applied along the mid-line of the back in a narrow strip between the withers and tailhead.

The 250 ml and 1.0 litre packs must be used with appropriate dosing equipment. Instructions for using the dispensing chamber:
a) Take dip tube and insert end into base of measuring cap with slotted end going to the bottom of the container.
b) Remove shipping cap from container.
c) Screw measuring cap onto container.
d) Select the correct dose rate by rotating the adjuster cap in either direction to position the dose indicator to the appropriate dose.
e) Gently squeeze the bottle to fill to level (any excess will return to the bottle) and then tip and apply to animal along backline.

4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary

No signs of toxicity appeared in trials up to 3 times the recommended dose rate.
Clinical symptoms of ivermectin toxicity include ataxia and depression.
No antidote has been identified.
In case of overdose, symptomatic treatment should be given.

4.11 Withdrawal period(s)

Meat and offal: 31 days.
Milk: Not permitted for use in lactating cattle producing milk for human consumption.

Do not use in non-lactating dairy cows, including pregnant dairy heifers, within 60 days of calving.

5 PHARMACOLOGICAL or IMMUNOLOGICAL PROPERTIES

ATC vet code:

QP54AA01.

Pharmacotherapeutic group:

endectocides,
avermectins

5.1 Pharmacodynamic properties

Ivermectin is a mixture of two compounds belonging to the avermectin family, which are a macrocyclic lactone group of endectocides. Avermectin is a microbial metabolite of the soil organism Streptomyces avermilitis. 

It is generally accepted that ivermectin exerts its action in two main ways, interference with neurotransmission and opening chloride ion channels.
The effect of ivermectin on the parasitic CNS is considered to operate through glutamate-mediated chloride channels. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).
The opening of pre-synaptic chloride ion channels results in an efflux of chloride ions and depolarisation of the nerve terminal. These effects interfere with normal neurotransmission between nerves and muscles, resulting in parasite paralysis and eventual death.

5.2 Pharmacokinetic particulars

After administration of the product, the ivermectin is absorbed through the skin into the circulation of the treated animal. The maximum concentration in plasma occurs around 70 hours after application. Peak concentrations of about 7 ng/ml are obtained. The residual antiparasitic effect of ivermectin is due to its persistence, which in turn is due in part to its long intrinsic half-life (t1/2β of approximately 210 hours), in part to its relatively high plasma protein binding (80% in cattle; binding remains relatively constant over time) and in part to the nature and type of the ivermectin formulation.

Elimination

is in the faeces (via biliary excretion).
Over 60% of the dose is excreted after 3 days.

6 PHARMACEUTICAL PARTICULARS

6.1 List of excipients


Isopropyl alcohol

Polypropoxylate-2-myristyl ether propionate
N-Methylpyrrolidone Benzyl Alcohol (E1519)
Water

6.2 Major incompatibilities

None known.

6.3 Shelf-life

Shelf-life of the veterinary medicinal product as packaged for sale: 2 years Shelf-life after first opening the immediate packaging: 6 months

6.4 Special precautions for storage

Do not store above 25°C.
Protect from light.
Store in the original container, tightly closed.
Keep the container in the outer carton If stored at temperatures below 0°C, the solution may appear cloudy.
Allowing to warm at room temperature will restore normal appearance without affecting efficacy.

6.5 Nature and composition of immediate packaging

250 ml white non-fluorinated or fluorinated high-density polyethylene bottle with a drawing tube and measuring device.
1.0 L white non-fluorinated or fluorinated high-density polyethylene bottle with a drawing tube and measuring device. 2.5 L white  non-fluorinated or fluorinated high-density polyethylene back-pack  with polypropylene strap and vented cap
5.0 L white non-fluorinated or fluorinated high-density polyethylene back-pack with polypropylene strap and vented cap

Closure:

White polypropylene screw-cap. 

Not all pack sizes may be marketed

6.6 Special precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products

THE PRODUCT IS EXTREMELY DANGEROUS TO FISH AND AQUATIC LIFE.
Do not contaminate surface water or ditches with product or the used container.
Any unused veterinary medicinal product or waste material derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

7 MARKETING AUTHORISATION HOLDER

ECO Animal Health Europe Limited
6th Floor
South Bank House
Barrow Street
Dublin 4
D04 TR29
Ireland

8 MARKETING AUTHORISATION NUMBER(S)

VPA22693/005/001

9 DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION

Date of first authorisation 30 August 2002
Date of last renewal: 20 December 2010

10 DATE OF REVISION OF THE TEXT

March 2019

Delivery Information

Delivery Service

Here at Agridirect we have joined forces with DPD to ensure all packages are delivered promptly and safely to you. We ship to all mainland countries within the EU. Deliveries take place Monday to Friday excluding bank holidays. Once your order has been dispatched from our warehouse you will be notified by email. If there is a delay with your order for any reason you will be contacted immediately. 

Due to Brexit we are temporarily unable to ship to the UK. Shipping to Northern Ireland will remain in place.

Delivery Times
Ireland (ROI & NI)EU (Mainland Only)
2-4 Working Days4-6 Working Days

Some product have an extended delivery time, this is noted on the products.

Delivery Rates

CountryOrders Under €99Orders Over €99
Ireland (ROI & NI)€6.99€0.00
Austria€19.99€13.00
Belgium€16.99€10.00
Czech Republic€19.99€13.00
Denmark€19.99€13.00
Finland€31.99€25.00
France€16.99€10.00
Germany€16.99€10.00
Hungary€23.99€17.00
Italy€29.99€23.00
Luxenburg€16.99€10.00
Netherlands€16.99€10.00
Poland€16.99€13.00
Portugal€31.99€25.00
Slovakia€23.99€17.00
Slovenia€23.99€17.00
Spain€29.99€23.00
Sweden€29.99€23.00

 

A selection of the products we sell are only licensed for sale within the Republic Of Ireland and can not be shipped outside of the country. These products are noted as only being available within the Republic of Ireland on the individual product pages.

There may be an addition charge on certain bulky items. This charge will be clearly marked on an applicable products and will be explained on the checkout page before payment has been made.

Agridirect Returns Policy

We’re sorry your purchase didn’t work out. But don’t worry; we have a great returns policy to help you out, plus returns are free.

All purchases can be returned to us within 14 days of delivery and returned goods must be received within 14 days from the date you informed us of the return.

Purchases may be opened for inspection but must not be used and must be repackaged securely in the original packaging if you wish to return it.
 

If we discover goods have been used or there has been a loss in value of the goods due to damage to the goods, while in your care or whilst being returned to us, we will reduce the amount refunded, which may amount to the full cost of the product, to cover loss of value of goods.

All returns should be complete which includes boxes, manuals and accessories that may have been included with the order.

All returns must be packaged appropriately for shipping, we will not accept responsibility for damages or loss which occur during shipping of a return product.

We accept no responsibility for goods damaged or lost while in transit to us. 

How do I return a product?

Making returns to us are free, simply follow the steps below and bring your package to an official DPD pickup point.

  • All returns must be accompanied with a fully filled out returns form which can be downloaded here.
  • To print off your return label click here or visit www.dpd.ie/returns and follow the on-screen instructions. Make sure and use your order number as your reference.
  • Bring your package to a DPD pickup point. To find your nearest drop off point here.

Once the returned product has been received into our warehouse and been fully inspected a refund will be issued.

For the return of bulk products please contact us at sales@agridirect.ie

I have received a damaged product from you, what should I do?

First off, if you have received a damaged electrical product from us, do not plug it in. Any electrical products that are plugged in are deemed ‘as used and accepted’ and are not accepted as returns. All damages must be reported to us via phone or email within 24hours of receipt of goods. Please ensure you check your items upon delivery.

How do I begin the returns process?

If you wish to begin the return process, please email us at sales@agridirect.ie and ensure the following information is included in your email. Your name, phone number, Order id, the item you wish to return, reason for return and if the product is damaged we require photos of the product.

Once you have sent us all required information a member of our team will assess your claim and will contact you as soon as possible. Please hold off on returning products until a member of our team has called you to confirm.

Refunds

Once the returned product has been returned to us and fully inspected a refund will be issued.

Please Note: A typical timeline for a refund to show in your account is up to 10 working days from the date processed, depending on your bank.

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