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Eprizero Pour-On (Eprinomectin)
Eprizero Pour-On (Eprinomectin)

Eprizero Pour-On (Eprinomectin)

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Eprizero Pour-on for cattle is a ready to use pour-on solution that is used in the treatment and gastrointestinal roundworms, lungworms, warbles, mange mites and lice. Eprizero Boasts a zero hour withdrawal time for dairy cattle and a reduced withdrawal time of 10 days for beef cattle.

Active Ingredient: Eprinomectin

Target Species: Beef Cattle, Dairy Cattle

Treats and Controls: Gastrointestinal roundworm, lungworm, warbles, lice, mange mites

Administration Method: Pour-On

Withdrawal Time: 10 days for cattle intended for meat and offal, zero hours for cattle producing milk for human consumption

Dosage for cattle: 1 ml per 10 kg of bodyweight.

Body Weight Dose Volume Number of full doses per pack:
2.5 Litre 5 Litre
50kg 5 ml 500 1000
100kg 10 ml 250 500
150kg 15 ml 166 333
200kg 20 ml 125 250
250kg 25 ml 100 200
300kg 30 ml 83 166
350kg 35 ml 71 142
400kg 40 ml 62 125
450kg 45 ml 55 111
500kg 50 ml 50 100
550kg 55 ml 45 90
600kg 60 ml 41 83

Always read the label and all enclosed information for Eprizero before administering to animals!

Key Features of  Eprizero Pour-on

Increase on milk production: Studies have shown that cattle treated with Eprizero can have an increase in their milk yield of up to 2 litres per animal per day.

Increased weight gain: Cattle treated with Eprizero have also been shown to graze for up to an hour longer every day. This leads to improved weight gain as well as improved milk yields.

Improved body conditions: The increase in grazing times leads also to an increase in the nutrients consumed by cattle. This increase in nutrients leads to healthier cattle with increased body conditions.

Improved fertility rates: The elimination of parasites and the improved overall health of the cattle will lead to increased fertility rates. Herds treated with Eprizero have shown increases of up to 20% in conception rates in the first year alone.

This product is only licensed for sale within the Republic of Ireland


Click here to Download Data Sheet

Health Products Regulatory Authority

Summary of Product Characteristics

Eprizero 5 mg/ml Pour-On Solution for Beef and Dairy Cattle.

1 ml of solution contains:

Active Substance:
Eprinomectin 5 mg

Butylated Hydroxytoluene (E321) 0.1 mg

For a full list of excipients, see section 6.1.

Pour-on solution.
A clear to very light yellow solution.


4.1 Target Species

Beef and dairy cattle.

1 ml of solution contains:

Active Substance:
Eprinomectin 5 mg

Butylated Hydroxytoluene (E321) 0.1 mg

For a full list of excipients, see section 6.1.

4.2 Indications for use, specifying the target species

Indicated for the treatment and prevention of the following parasites:

Gastrointestinal Roundworms (adults and fourth stage larvae):
Ostertagia spp.,
Ostertagia lyrata (adult),
Ostertagia ostertagi (including inhibited O. ostertagi),
Cooperia spp. (including inhibited Cooperia spp.),
Cooperia oncophora,
Cooperia pectinata,
Cooperia punctata,
Cooperia surnabada,
Haemonchus placei,
Trichostrongylus spp.,
Trichostrongylus axei,
Trichostrongylus colubriformis,
Bunostomum phlebotomum,
Nematodirus helvetianus,
Oesophagostomum spp. (adult),
Oesophagostomum radiatum,
Trichuris spp. (adult).

Lungworms (adults and fourth stage larvae):
Dictyocaulus viviparus

Warbles (parasitic stages):
Hypoderma bovis,
H. lineatum

Mange Mites:
Chorioptes bovis,
Sarcoptes scabiei var bovis

Damalinia bovis (biting lice),
Linognathus vituli (sucking lice),
Haematopinus eurysternus (sucking lice),
Solenopotes capillatus (sucking lice).

Horn Flies:
Haematobia irritans.

Prolonged Activity

Applied as recommended, the product prevents reinfections with:

Parasite * Prolonged Activity
Dictyocaulus viviparus up to 28 days
Ostertagia spp up to 28 days
Oesophagostomum radiatum up to 28 days
Cooperia spp up to 21 days
Trichostrongylus spp up to 21 days
Haemonchus placei up to 14 days
Nematodirus helvetianus up to 14 days

*The following parasite species are included within each of the relevant genera: Ostertagia ostertagi, O. lyrata,
Cooperia oncophora, C. punctata, C. surnabada, Trichostronglus axei, T. colubroformis.

4.3 Contraindications

This product is formulated only for topical application to beef and dairy cattle, including lactating dairy cattle.
Do not
use in other animal species.
Do not administer orally or by injection.
Do not use in animals with known hypersensitivity to the active ingredient or any of the excipients.

4.4 Special warnings for each target species

The details provided in section 4.10 apply.
If there is a risk for re-infestation, the advice of a veterinarian should be sought regarding the need for and frequency of repeat administration.
Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:
- Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
- Underdosing, which may be due to underestimation of bodyweight, misadministration of the product, or lack of
  calibration of the dosing device (if any).

Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal

Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.

To date no resistance to eprinomectin (a macrocyclic lactone) has been reported within the EU.
However resistance to other macrocyclic lactones has been reported in parasite species in cattle within the EU. Therefore, use of this product should be based on local (regional, farm) epidemiological information about susceptibility of nematodes and recommendations on how to limit further selection for resistance to anthelmintics.

While mite and louse numbers decline rapidly following treatment, due to the feeding habits of the parasites, in some
cases several weeks may be required for complete eradication.
For effective use, the product should not be applied to areas of the backline covered with mud or manure.

4.5 Special precautions for use

i. Special precautions for use in animals

Not to be used in other species; avermectins can cause fatalities in dogs.
The product should be applied only to healthy skin.

ii. Special precautions to be taken by the person administering the veterinary medicinal product to

This product may be irritating to human skin and eyes and may cause hypersensitivity.
Avoid skin and eye contact with the product during treatment and when handling recently treated animals.
Users should wear rubber gloves, boots and a waterproof coat when applying the product.
Should clothing become contaminated, remove as soon as possible and launder before re-use.
If accidental skin contact occurs, wash the affected area immediately with soap and water.
If accidental eye exposure occurs, flush eyes immediately with water.
This product may be toxic after accidental ingestion.
Avoid accidental ingestion of the product by hand to mouth contact.
Do not smoke, eat or drink while handling the product.
In the event of ingestion, wash out mouth with water and seek medical advice.
Wash hands after use.
This product is flammable. Keep away from sources of ignition.
Inhalation of the product may cause irritation.
Use only in well ventilated areas or outdoors.

iii. Other precautions

Eprinomectin is very toxic to dung fauna and aquatic organisms and may accumulate in sediments.
The risk to aquatic ecosystems and dung fauna can be reduced by avoiding too frequent and repeated use of
eprinomectin (and products of the same anthelmintic class) in cattle.
The risk to aquatic ecosystems will be further reduced by keeping treated cattle away from water bodies for two to four weeks after treatment.

4.6 Adverse reactions (frequency and seriousness)

No undesirable effects have been identified when the product is used at the recommended dose rate.

4.7 Use during pregnancy, lactation or lay

May be used in dairy cattle during all stages of lactation.
Studies have demonstrated a wide safety margin. Studies conducted at three times the recommended use level of 0.5 mg eprinomectin/kg b.w. had no adverse effect on breeding performance of cows or bulls.

4.8 Interaction with other medicinal products and other forms of interaction

None known.

4.9 Amounts to be administered and administration route

Administer only by topical application at the dose rate of 1 ml per 10 kg of body weight, corresponding to the
recommended dose rate of 0.5 mg eprinomectin per kg b.w. The product should be applied topically by pouring along
the backline in a narrow strip extending from the withers to the tailhead.

Rainfall at anytime before or after treatment will not affect the efficacy of the product.
To ensure administration of a correct dose, bodyweight should be determined as accurately as possible; accuracy of the dosing device (dosing cup or dosing gun delivery system) should be checked.

For best results use as part of a program to control both internal and external parasites of cattle based on the
epidemiology of these parasites.

4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary

In adult cattle, after administration of 5 times the recommended dose (2.5 mg eprinomectin/kg body weight), mild hair
loss was observed. No other signs of toxicity were seen.

No antidote has been identified.

4.11 Withdrawal Period(s)

Meat & offal: 10 days
Milk: zero hours.


Pharmacotherapeutic group:

ATC Vet Code:


5.1 Pharmacodynamic properties

Mode of action

Eprinomectin is a member of the macrocyclic lactone class of endectocides.
Compounds of the class bind selectively
and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve or muscle cells.
This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite.
Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the
neurotransmitter gamma-aminobutyric acid (GABA).
The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated
chloride channels; the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels,
and they do not readily cross the blood-brain barrier.

5.2 Pharmacokinetic properties

The bioavailability of topically applied eprinomectin in cattle is about 30% with most absorption occurring by about 10
days after treatment. Eprinomectin is not extensively metabolized in cattle following topical administration. In all
biological matrices, the B1a component of eprinomectin is the single most abundant residue.

Eprinomectin consists of the components B1a ( 90 %) and B1b ( 10 %) which differ by a methylene unit and is not
extensively metabolized in cattle. Metabolites amount to approximately 10% of the total residues in plasma, milk,
edible tissues and faeces.

The metabolism profile is nearly identical, qualitatively and quantitatively, in the above biological matrices and does
not change significantly with time after administration of eprinomectin. The percent contribution of B1a and B1b to the
overall metabolite profile remains constant. The ratio of the two drug components in the biological matrices is identical to that in the formulation demonstrating that the two eprinomectin components are metabolized with nearly equal rate constants. Since the metabolism and the tissue distribution of the two components are quite similar, the
pharmacokinetics of the two components would be also similar.
Eprinomectin is strongly linked to plasma proteins (99 %). Faeces is the major route of elimination.

5.3 Environmental properties

Like other macrocyclic lactones, eprinomectin has the potential to adversely affect non-target organisms. Following
treatment, excretion of potentially toxic levels of eprinomectin may take place over a period of several weeks. Faeces
containing eprinomectin excreted onto pasture by treated animals may reduce the abundance of dung feeding organisms which may impact on the dung degradation.
Eprinomectin is very toxic to aquatic organisms and may accumulate in sediments.


6.1 List of excipients

Butylated Hydroxytoluene (E321)
Cetearyl Ethylhexanoate and Isopropyl Myristate
Propylene Glycol Dicaprylocaprate
Denatonium Benzoate
Isopropyl Alcohol

6.2 Incompatibilities

No major incompatibility has been identified.

6.3 Shelf-life
Shelf-life of the veterinary medicinal product as packaged for sale: 24 months.
Shelf-life after first opening the immediate packaging: 3 months

6.4 Special precautions for storage

Do not store above 30°C.
Keep container in the outer carton.
Protect from light.

6.5 Nature and composition of immediate packaging

Translucent 250 mL and 1 L HDPE containers with integral squeeze measure pour system and white HDPE screw caps.
White 1 L, 2.5 L and 5 L HDPE backpacks and white polypropylene screw caps.

Not all packs sizes may be marketed.

6.6 Special precautions for the disposal of unused veterinary medicinal products or waste materials

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
Extremely dangerous to fish and aquatic life. Do not contaminate ponds, waterways or ditches with the product or
empty container.

Norbrook Laboratories Limited
Station Works
Co. Down
BT35 6JP
Northern Ireland


VPA: 10999/142/001


1st March 2013


October 2013

Cattle Pour-ons

These should be applied along the length of the flattest part of the animal’s back, from the withers to the tail head.
In general, animals should not be treated when the hair is wet or if rain is anticipated within two hours of treatment. However, some products are waterproof and can be used on wet animals.
Areas of damaged skin should be avoided, as should areas contaminated with mud or manure


What is Eprinomectin?

Eprinomectin is a semi-synthetic compound of the avermectin family, intended for the treatment of internal and external parasites in cattle and in lactating cows.
Eprinomectin is a mixture of two homologues, eprinomectin B1a (90%) and eprinomectin B1b (10%), which differ by a methylene group in the C25.
The recommended dosage regimen is a single dose of 0.5 mg/kg bw (0.1 ml/10 kg bw) applied topically along the midline of the animal's back.  

How does Eprinomectin work?

The precise mode of action of eprinomectin remains unknown, despite extensive investigations with a variety of compounds from the same class.

Delivery Information

Delivery Service

Here at Agridirect we have joined forces with DPD to ensure all packages are delivered promptly and safely to you. We ship to all mainland countries within the EU. Deliveries take place Monday to Friday excluding bank holidays. Once your order has been dispatched from our warehouse you will be notified by email. If there is a delay with your order for any reason you will be contacted immediately. 

Due to Brexit we are temporarily unable to ship to the UK. Shipping to Northern Ireland will remain in place.

Delivery Times
Ireland (ROI & NI) EU (Mainland Only)
2-4 Working Days 4-6 Working Days

Some products have an extended delivery time, this is noted on the products.

Delivery Rates

Country Orders Under €129 Orders Over €129
Ireland (ROI & NI) €7.99 €0.00
Austria €24.99 €17.00
Belgium €21.99 €14.00
Czech Republic €24.99 €17.00
Denmark €24.99 €17.00
Finland €36.99 €29.00
France €21.99 €14.00
Germany €21.99 €14.00
Hungary €28.99 €21.00
Italy €34.99 €23.00
Luxenburg €21.99 €14.00
Netherlands €21.99 €14.00
Poland €21.99 €17.00
Portugal €36.99 €29.00
Slovakia €28.99 €21.00
Slovenia €28.99 €21.00
Spain €34.99 €27.00
Sweden €34.99 €27.00


A selection of the products we sell are only licensed for sale within the Republic Of Ireland and can not be shipped outside of the country. These products are noted as only being available within the Republic of Ireland on the individual product pages.

There may be an addition charge on certain bulky items. This charge will be clearly marked on an applicable products and will be explained on the checkout page before payment has been made.

Agridirect Returns Policy

We’re sorry your purchase didn’t work out. But don’t worry; we have a great returns policy to help you out.

All purchases can be returned to us within 14 days of delivery and returned goods must be received within 14 days from the date you informed us of the return.

Purchases may be opened for inspection but must not be used and must be repackaged securely in the original packaging if you wish to return it.

If we discover goods have been used or there has been a loss in value of the goods due to damage to the goods, while in your care or whilst being returned to us, we will reduce the amount refunded, which may amount to the full cost of the product, to cover loss of value of goods.

All returns should be complete which includes boxes, manuals and accessories that may have been included with the order.

All returns must be packaged appropriately for shipping, we will not accept responsibility for damages or loss which occur during shipping of a return product.

We accept no responsibility for goods damaged or lost while in transit to us. 

How do I return a product?

We have partnered with DPD to make your returns process easy and secure. simply follow the steps below and bring your package to an official DPD pickup point.

1) All returns must be accompanied with a fully filled out returns form which can be downloaded here.

2) To print off your return label click here or visit and follow the on-screen instructions. Make sure and use your order number as your reference.

  • Select “Continue as Guest”
  • Select “Agridirect” from the drop-down menu
  • Select your reason for returning
  • Select the size of the package you wish to return
  • Accept DPD’s terms and conditions
  • Fill in your payment details
  • Fill in your own details
  • Follow the instructions to print off your label

3) Bring your package to a DPD pickup point. To find your nearest drop off point here.

Once the returned product has been received into our warehouse and been fully inspected a refund will be issued.

If you choose not to use the DPD returns service we recommend that you use a method that can be tracked.

For the return of bulk products please contact us at

I have received a damaged product from you, what should I do?

First off, if you have received a damaged electrical product from us, do not plug it in. Any electrical products that are plugged in are deemed ‘as used and accepted’ and are not accepted as returns. All damages must be reported to us via phone or email within 24hours of receipt of goods. Please ensure you check your items upon delivery.

How do I begin the returns process?

If you wish to begin the return process, please email us at and ensure the following information is included in your email. Your name, phone number, Order id, the item you wish to return, reason for return and if the product is damaged we require photos of the product.

Once you have sent us all required information a member of our team will assess your claim and will contact you as soon as possible. Please hold off on returning products until a member of our team has called you to confirm.


Once the returned product has been returned to us and fully inspected a refund will be issued.

Please Note: A typical timeline for a refund to show in your account is up to 10 working days from the date processed, depending on your bank.



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