Free Delivery on orders over €89
Call today: 049 9527944
Free Delivery on orders over €89
€5 OFF ANY ORDER
Join our newsletter >>>
Hello:  |
Eprinex Multi Pour-On (Eprinomectin)

Eprinex Multi Pour-On (Eprinomectin)

was: €~~productWasPrice~~Our Price: 129.00

Volume:

Quantity:

Availability: In Stock
Free Delivery
with this product
Delivery Time: 2-4 Days
Information

Eprinex Pour-on is designed for use on beef and dairy cattle as well as sheep and goats. It is used for the treatment of and control of gastro-intestinal worms (including inhibited Ostrtagia ostertagia and Cooperia spp.), lungworms, warbles, sucking and biting lice, chorioptic and sarcoptic mange mites in beef and dairy cattle. Eprinex Pour-on boasts a very short withdrawal time for beef cattle and no withdrawal time for dairy cattle. Eprinex provides fast-acting treatment, stopping worm egg output faster than moxidectin and doramectin pour-ons. 

Studies

Eprinex has been shown to control sub-clinical parasites and to yield an increase in milk production. In a study of dairy cattle, dairy cattle that had been treated with Eprinex showed a significant and constant increase in milk production. In the first 6 months of lactation, milk production (daily) increased by 0.94kg relative to the placebo group. When Eprinex was give to a herd of cattle diagnosed with Sarcoptic mange, milk production increased by almost 1.5kg per cow per day. (Data courtesy of Boehringer Ingelheim). 

In a study of Eprinex treated heifers, calving to conception interval was reduced by an average of 12.9 days. 19.9% more first time heifers were pregnant after the first service. 

Active Ingredient: Eprinomectin

Target Species: Cattle, sheep, goats

Treats and Controls: Gastro-intestinal worm, lungworm, sucking and biting lice and mange mites

Administration Method: Pour-On

Withdrawal Time: Cattle: Meat and offal: 15 days. Milk:  zero hours. Sheep:  Meat and offal: 2 days Milk: zero hours  Goats: Meat and offal: 1 day Milk: zero hours 

Dosage: 1 ml per 10 kg of bodyweight.

Body WeightDose VolumeNumber of full doses per pack:
250 ml1 Litre2.5 Litre5 Litre
50kg5 ml502005001000
100kg10 ml25100250500
150kg15 ml1666166333
200kg20 ml1250125250
250kg25 ml1040100200
300kg30 ml83383166
350kg35 ml72871142
400kg40 ml62562125
450kg45 ml52255111
500kg50 ml52050100
550kg55 ml4184590
600kg60 ml4164183

Always read the label and all enclosed information for Eprinex Pour-on before administering to animals!

Benefits of Eprinex Pour on

  • Broad parasite protection for your cattle, sheep and goats
  • The convenience of a broad-spectrum Pour-On
  • Most potent and fastest acting endectocide available
  • Absorbed more rapidly – faster acting
  • Sustained activity to kill more species of worms for longer than any other pour-on
  • No milk withholding period
  • Short meat withholding
  • No need for protective gear
  • Completely weatherproof - not just rainfast

Trials demonstrate that treatment of lactating dairy cows with Eprinex Pour-on can increase milk yield by up to 2 litres per cow per day.

• Treatment with EPRINEX increased milk production:

• Over the whole lactation treated cows produced:
   – 63 L more milk
   – 2.8 kg more protein
   – 2.8 kg more milk fat.

• Treatment cost was recouped within 50 days of calving, with the
    treatment investment trebled by the end of lactation.

"The Power To Produce Your Best"

This Product is only licensed for sale in the Republic of Ireland

Data Sheet

Summary of Product Characteristics

1 NAME OF THE VETERINARY MEDICINAL PRODUCT

Eprinex Multi 5 mg/ml pour-on for beef and dairy cattle, sheep and goats

2 QUALITATIVE AND QUANTITATIVE COMPOSITION

Each ml contains:

 

Active substance:

Eprinomectin......................................................................................... 5.0 mg 

Excipients:

Butylhydroxytoluene (E321)................................................................. 0.1 mg

Alpha-tocopherol……………………………………………………….max. 0.06 mg

 

For the full list of excipients, see section 6.1.

3 PHARMACEUTICAL FORM

Pour-on solution.

Clear slightly yellow solution.

4 CLINICAL PARTICULARS

4.1 Target Species

Beef and dairy Cattle

Sheep

Goats

 

4.2 Indications for use, specifying the target species

Treatment of infestation by the following parasites sensitive to eprinomectin:

 

Cattle

 

PARASITE

ADULT

L4

Inhibited L4

Gastrointestinal Roundworms:

 

 

 

Ostertagiaspp.

 

O. lyrata

 

 

O. ostertagi

Cooperiaspp.

C. oncophora

 

C. punctata

 

C. surnabada C. pectinata

 

Haemonchus placei

 

Trichostrongylusspp.

 

T. axei

 

T. colubriformis

 

Bunostomum phlebotomum

 

Nematodirus helvetianus

 

Oesophagostomumspp.

 

 

Oesophagostomum radiatum

 

Trichurisspp.

 

 

Lungworm:

 

 

 

Dictyocaulus viviparus

 

 

Warbles(parasitic stages)

Hypoderma bovis

Hypoderma lineatum

 

Mange mites

Chorioptes bovis

Sarcoptes scabieivar. bovis

 

Lice

Linognathus vituli

Damalinia bovis

Haematopinus eurysternus

Solenopotes capillatus

 

Flies

Haematobia irritans

PROLONGED ACTIVITY

Applied as recommended, the product prevents reinfestations with:

 

Parasite

Prolonged Activity

Dictyocaulus viviparus

Up to 28 days

Ostertagia ostertagi

Up to 28 days

Oesophagostomum radiatum

Up to 28 days

Cooperia punctata

Up to 28 days

Cooperia surnabada Cooperia oncophora

Up to 28 days

Up to 28 days

22 August 2019                                        CRN008Q4X

Nematodirus helvetianus

Up to 14 days

Trichostrongylus colubriformis

Up to 21 days

Trichostrongylus axei

Up to 21 days

Haemonchus placei

Up to 21 days

 

For best results Eprinex Multi should be part of a programme to control both internal and external parasites of cattle based on the epidemiology of these parasites.

 

Sheep

Gastrointestinal roundworms (adults)

Teladorsagia circumcincta (pinnata/trifurcata)

Haemonchus contortus

Trichostrongylus axei

Trichostrongylus colubriformis

Nematodirus battus

Cooperia curticei

Chabertia ovina

Oesophagostomum venulosum

 

Lungworm (adult)

Dictyocaulus filaria

 

Goats

Gastrointestinal roundworms (adult)

Teladorsagia  circumcincta (pinnata/trifurcata)

Haemonchus contortus

Trichostrongylus axei

Trichostrongylus colubriformis

Nematodirus battus

Cooperia curticei

Oesophagotomum venulosum

 

Lungworm (adult)Dictyocaulus filaria

4.3 Contraindications

This product is formulated only for topical application to cattle, sheep and goatsincluding lactating dairy animals. Do not use in other animal species.

 

Do not use in cases of hypersensitivity to the active substance or to any of the excipients.

4.4 Special warnings for each target species

For effective use, the product should not be applied to areas of the backline covered with mud or manure. The product should be applied only on healthy skin.

 

In cattle, rainfall before, during or after the application of the product, has been shown to have no impact on its efficacy. It also has been demonstrated that haircoat length has no impact on the product’s efficacy. The effect of rainfall and haircoat length on efficacy has not been evaluated in sheep and goats.

 

For cattle, in order to limit cross-transfer of eprinomectin, treated animals may be separated from untreated animals. Non-compliance withthis recommendation may lead to residue violations in untreated animals.

Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:

  • Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.

 

  • Underdosing, which may be due to underestimation of bodyweight, misadministration of the product, or lack of calibration ofthe dosing device (if any).

Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.

To date no resistance to eprinomectin (a macrocyclic lactone) has been reported in cattle and sheep while resistance to eprinomectin has been reported in goats within the EU. However resistance to other macrocyclic lactones has been reported in nematode populations in cattle, sheep and goats within the EU, which may be associated with side-resistance to eprinomectin. Therefore, use of this product should be based on local (regional, farm) epidemiological information about susceptibility of nematodes and recommendations on how to limit further selection for resistance to anthelmintics.

While mite and louse numbers decline rapidly following treatment, due to the feeding habits of some mites, in some cases several weeks may be required for complete eradication.

4.5 Special precautions for use

Special precautions for use in animalsFor external use only.

Not to be used in other species; avermectins can cause fatalities in dogs, especially Collies, Old English Sheepdogs and related breeds and crosses, and also in turtles/tortoises.

To avoid secondary reactions due to the death of Hypodermalarvae in the oesophagus or in the spine, it is recommended to administer the product at the end of warble fly activity and before the larvae reach their resting sites.

 

Special precautions to be taken by the person administering the veterinary medicinal product to animalsDo not smoke, eat or drink while handling the product.

Wash hands after use.

This product may be irritating to skin and eyes. Avoid contact with eyes and skin

People with known hypersensitivity to the active substance or to any of the excipients should avoid contact with the product.

Operators should wear rubber gloves, boots and waterproof coat when applying the product.

Should clothing become contaminated, remove as soon as possible and launder before re-use.

If accidental skin contact occurs, wash the affected area immediately with soap and water.

Should accidental eye exposure occur, flush eyes immediately with plenty of clean water. Should irritation persist, seek medical advice.

Do not ingest.

In case of accidental ingestion, rinse out mouth thoroughly with water, seek medical advice immediately and show the package insert or the label to the physician.

 

Other precautions

Eprinomectin is very toxic to dung fauna and aquatic organisms, is persistent in soils and may accumulate in sediments. The risk to aquatic ecosystems and dung fauna can be reduced by avoiding repeated use of eprinomectin (and products of the same anthelmintic class).

In order to reduce the risk to aquatic ecosystems, treated animals should not have direct access to water bodies for a minimum of two weeks after treatment.

4.6 Adverse reactions (frequency and seriousness)

In very rare cases, pruritus and alopecia have been observed after the use of the veterinary medicinal product

 

The frequency of adverse reactions is defined using the following convention:

  • very common (more than 1 in 10 animals treated displaying adverse reaction(s))
  • common (more than 1 but less than 10 animals in 100 animals treated)
  • uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
  • rare (more than 1 but less than 10 animals in 10,000 animals treated)
  • very rare (less than 1 animal in 10,000 animals treated, including isolated reports).

4.7 Use during pregnancy, lactation or lay

Laboratory studies (rat, rabbit) have not produced any evidence of a teratogenic or embryotoxic effects due to the use of eprinomectin at therapeutic doses. Laboratory studies in cattle have not produced any evidence of a teratogenic or foetotoxic effect at the recommended therapeutic dose. The product can be used in dairy cattle during pregnancy and lactation.

 

The safety of eprinomectin during pregnancy in sheep and goats has not been tested. Use only according to the benefit/risk assessment of the responsible veterinarian in these species.

4.8 Interaction with other medicinal products and other forms of interactions

No interactions with other medicines and no other forms of interactions are known.

Since eprinomectin binds extensively to plasmatic proteins, this should be taken into account if it is used in association with other molecules having the same characteristics.

4.9 Amounts to be administered and administration route

Pour-on use

 

To ensure administration of a correct dose, bodyweight should be determined as accurately as possible; accuracy of the dosing device should be checked. If animals are to be treated collectively rather than individually, they should be grouped according to their bodyweight and dosed accordingly, in order to avoid under- and over- dosing.

 

The product should be applied topically by pouring along the backline in a narrow strip extending from the withers to the tailhead.

 

Cattle:

Administer by topical application at the dose rate of 0.5 mg eprinomectin per kg bodyweight, corresponding to the recommended dose rate of 1 ml per 10 kg bodyweight.

 

Sheep and goats:

Administer by topical application at the dose rate of 1.0 mg eprinomectin per kg bodyweight, corresponding to the recommended dose rate of 2 ml per 10 kg bodyweight.

When administering the product along the backline, part the fleece/coat and place applicator nozzle or bottle spout against the skin.

 

Method of administration

For 250 ml and 1 litre bottles :

  • Attach the metering cup to the bottle.
  • Set the dose by turning the top section of the cup to align the correct bodyweight with the pointer on the knurled cap. When bodyweight is between markings, use the higher setting.
  • Hold the bottle upright and squeeze it to deliver a slight excess of the required dose. Release the pressure and tilt the bottle to deliver the dose. For the 1 litre bottle: when a 10 ml or 15 ml dose is required, turn the pointer to “STOP” before delivering the dose. The off (STOP) position will close the system between dosing.
  • The dosing cup should not be stored attached to the bottle when not in use. Remove the cup after each use and replace with the bottle cap.

 

For 2.5 and 5 litre

  • Attach the open end of the draw-off tubing to an appropriate dosing gun.
  • Attach draw-off tubing to the cap with the stem that is included in the pack. Replace shipping cap with the cap having the draw-off tubing. Tighten the draw-off cap.
  • Gently prime the dosing gun, checking for leaks.
  • Follow the dosing gun manufacturer’s directions for adjusting the dose.

 

4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary

No signs of toxicity were observed when 8 - week old calves were treated at up to 5 times the therapeutic dose (2.5 mg eprinomectin/kg bodyweight.) 3 times at 7 - day intervals.

One calf treated once at 10 times the therapeutic dose (5 mg/kg bodyweight.) in the tolerance study showed transient mydriasis. There were no other adverse reactions to the treatment.

 

No signs of toxicity were observed when 17 - week old sheep were treated at doses up to 5 times the therapeutic dose (5 mg eprinomectin/kg bodyweight) 3 times at 14 - day intervals.

 

No antidote has been identified.

4.11 Withdrawal period(s)

Cattle:

Meat and offal: 15 days.

Milk:  zero hours.

Sheep:

Meat and offal: 2 days

Milk: zero hours Goats:

Meat and offal: 1 day

Milk: zero hours

5 PHARMACOLOGICAL or IMMUNOLOGICAL PROPERTIES

Pharmacotherapeutic group: Antiparasitic products, Avermectins. ATCvet code: QP54AA04

5.1 Pharmacodynamic properties

Eprinomectin is a member of the macrocyclic lactone class of endectocides. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve or muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite.

Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).

The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels; the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels, and they do not readily cross the blood-brain barrier.

5.2 Pharmacokinetic particulars

Eprinomectin is bound extensively to plasma proteins (99 %).

 

Pharmacokinetic studies have been conducted in lactating and non-lactating animals, administered topically at a single dosage of 0.5 mg/kg body weight in cattle and at 1 mg/kg bodyweight in sheep and goats.

 

For cattle, results from two representative studies found mean peak plasma concentrations of 9.7 and 43.8 ng/ml that were observed at 4.8 and 2.0 days post dose. The corresponding elimination half-lives in plasma were 5.2 and 2.0 days, and mean area-under-the-curve values of 124 and 241 ng*day/ml.

 

Eprinomectin is not extensively metabolized in cattle following topical administration. Faeces was the major route of elimination of the drug in beef cattle and dairy cows.

 

For sheep, a mean peak plasma concentration (Cmax) of 6.20 ng/ml was observed following a topical dose of 1mg/kg. The half-life in plasma was 6.4 days with mean area under the curve (AUClast) value of  48.8 ng*day/ml.

 

For goats, peak mean plasma concentrations ranging from 3 to 13.1 ng/ml were observed from day 1 to day 2 post dose. The half life in plasma ranged from less than one day to 3 days with area under the curve mean values ranging from 15.7 to 39.1 ng-day/ml.

 

An in vitro microsomal metabolism study was conducted using liver microsomes isolated from cattle, sheep and goats. It showed that the differences in pharmacokinetics observed between cattle, sheep and goats do not result from differences in the rate or extent of metabolism but suggests more complete absorption of eprinomectin by cattle.

 

Environmental properties

 

See section 4.5 (other precautions).

 

Like other macrocyclic lactones, eprinomectin has the potential to adversely affect non-target organisms. Following treatment, excretion of potentially toxic levels of eprinomectin may take place over a period of several weeks. Faeces containing eprinomectin excreted onto pasture by treated animals may reduce the abundance of dung feeding organisms which may impact on the dung degradation.

6 PHARMACEUTICAL PARTICULARS

6.1 List of excipients

Butylhydroxytoluene (E321)

Propylene glycol dicaprylocaprate Alpha-tocopherol

6.2 Major incompatibilities

In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.

6.3 Shelf-life

Shelf life of the veterinary medicinal product as packaged for sale: 3 years. Shelf life after first opening the immediate packaging: see expiry date.

6.4 Special precautions for storage

Keep the container in the outer carton in order to protect from light.

This veterinary medicinal product does not require any special temperature storage conditions.Store container upright.

6.5 Nature and composition of immediate packaging

250 ml and 1 L HDPE bottle

2.5 and 5 L HDPE back pack

Sealed foil and tamper evident HDPE screw cap with polypropylene liner

 

 

250 ml bottle with 2 measuring devices of 25 ml (1 for cattle, 1 for sheep/goat)

1L bottle with 2 measuring devices (1 of 60 ml for cattle, 1 of 25 ml for sheep/goat)

2.5L back-pack with a dispensing cap

5L back-pack with a dispensing cap

One bottle or one back-pack per cardboard box.

The 2.5 litre and 5 litre back-packs are designed for use with a suitable automatic dispensing gun. Not all pack sizes may be marketed.

6.6 Special precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

 

Do not contaminate surface waters or ditches with the product or used container.

7 MARKETING AUTHORISATION HOLDER

Boehringer Ingelheim Vetmedica GmbH

Binger Strasse 173

55216 Ingelheim am Rhein

Germany

  1. MARKETING AUTHORISATION NUMBER(S)

VPA10454/034/001

  1. DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION

Date of first authorisation: 09 December 2016

10 DATE OF REVISION OF THE TEXT

August 2019

Delivery

 

Delivery Information

Here at Agridirect we have joined forces with DPD to ensure all packages are delivered promptly and safely to you. We ship to all mainland countries within the EU. Deliveries take place Monday to Friday excluding bank holidays. Once your order has been dispatched from our warehouse you will be notified by email. If there is a delay with your order for any reason you will be contacted immediately. 

Delivery Times
Ireland (ROI & NI)United Kingdom (Mainland Only)EU (Mainland Only)
1-3 Working Days2-4 Working Days4-6 Working Days

Some product have an extended delivery time, this is noted on the products.

Delivery Rates

Delivery Rates
CountryOrders Under €70Orders Over €70
Ireland (ROI & NI)€4.99€0.00
Austria€17.99€13.00
Belgium€14.99€10.00
Czech Republic€17.99€13.00
Denmark€17.99€13.00
Finland€29.99€25.00
France€14.99€10.00
Germany€14.99€10.00
Hungary€21.99€17.00
Italy€27.99€23.00
Luxenburg€14.99€10.00
Netherlands€14.99€10.00
Poland€14.99€13.00
Portugal€29.99€25.00
Slovakia€21.99€17.00
Slovenia€21.99€17.00
Spain€27.99€23.00
Sweden€27.99€23.00
United Kingdom (Mainland Only)€14.99€10.00

 

 

A selection of the products we sell are only licensed for sale within the Republic Of Ireland and can not be shipped outside of the country. These products are noted as only being available within the Republic of Ireland on the individual product pages

There may be an addition charge on certain bulky items. This charge will be clearly marked on an applicable products and will be explained on the checkout page before payment has been made.

 

Returns

Returns Policy

We’re sorry your purchase didn’t work out. But don’t worry; we have a great returns policy to help you out.
 

All purchases can be returned to us within 14 days of delivery and returned goods must be received within 14 days from the date you informed us of the return.
 

Purchases may be opened for inspection but must not be used and must be repackaged securely in the original packaging if you wish to return it.
 

If we discover goods have been used or there has been a loss in value of the goods due to damage to the goods, while in your care or whilst being returned to us, we will reduce the amount refunded, which may amount to the full cost of the product, to cover loss of value of goods.
 

We accept no responsibility for goods damaged or lost while in transit to us. 
 

The cost of the return, including all packaging and freight, lies solely with the consumer.
 

I have received a damaged product from you, what should I do?

First off, if you have received a damaged electrical product from us, do not plug it in. Any electrical products that are plugged in are deemed ‘as used and accepted’ and are not accepted as returns. All damages must be reported to us via phone or email within 24hours of receipt of goods. Please ensure you check your items upon delivery.

How do I begin the returns process?

If you wish to begin the return process, please email us at sales@agridirect.ie and ensure the following information is included in your email. Your name, phone number, Order id, the item you wish to return, reason for return and if the product is damaged we require photos of the product.

Once you have sent us all required information a member of our team will assess your claim and will contact you as soon as possible. Please hold off on returning products until a member of our team has called you to confirm.

 

Packaging

All returns must be the complete product which includes boxes, manuals and accessories that may have been include with the order.

All returns must be packaged appropriately for shipping, we will not accept responsibility for damages or loss which occur during shipping of a return product.
 

Address: Please ship the product to the following address: Agridirect, Drumrahan Retail, Church Street, Ballyconnell, Co Cavan
 

Refunds

Once the returned product has been returned to us and fully inspected a refund will be issued.

Please Note: A typical timeline for a refund to show in your account is up to 10 working days from the date processed, depending on your bank.

Read our reviews:

Secure online payments with Realex

You might also like...

From
€375.00
From
€249.00
From
€195.00
©2019 Agridirect.ie Drumrahan Retail Ltd
webdesign by dmac media