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Elivec Pour-On- 5 litre (Eprinomectin)
Elivec Pour-On- 5 litre (Eprinomectin)

Elivec Pour-On- 5 litre (Eprinomectin)

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Elivec Pour-on for Beef and Dairy Cattle is a ready to use pour-on solution for the treatment and control of gastro-intestinal worms (including inhibited Ostrtagia ostertagia and Cooperia spp.), lungworms, warbles, sucking and biting lice, chorioptic and sarcoptic mange mites in both beef and dairy cattle. Elivec Pour-on comes with a very short withdrawal period of 15 days for beef cattle and zero milk withhold in dairy animals. Elivec Pour-On offers efficiency and easy pour-on application saving both farmers time and money. 

Active Ingredient: Eprinomectin

Target Species: Cattle

Administration Method: Pour-On, applied along the backline in a narrow strip extending from the withers to the tail head. 

Treats and Controls: Gastro-intestinal worm, lungworm, sucking and biting lice, mange mites, warbles and horn flies

Withdrawal Time: 15 days for cattle intended for meat and offal, there is no withdrawal time for cattle producing milk for human consumption.

Dosage: 1 ml per 10 kg of bodyweight 

Body WeightDose VolumeNumber of full doses per pack:
5 Litre
50kg5 ml1000
100kg10 ml500
150kg15 ml333
200kg20 ml250
250kg25 ml200
300kg30 ml166
350kg35 ml142
400kg40 ml125
450kg45 ml111
500kg50 ml100
550kg55 ml90
600kg60 ml83

Always read the label and all enclosed information for Elivec Pour-on before administering to animals!

Key Features of Elivec Pour on

  • The convenience of a broad-spectrum Pour-On
  • Available in 5 litre
  • Most potent and fastest acting endectocide available
  • Absorbed more rapidly – faster acting
  • Sustained activity to kill more species of worms for longer than any other pour-on
  • No milk withholding period
  • Short meat withhold
  • No need for protective gear
  • Completely weatherproof - not just rainfast

Trials demonstrate that treatment of lactating dairy cows with Elivec Pour-on can increase milk yield by up to 2 litres per cow per day.

• Treatment with ELIVEC increased milk production:

• Over the whole lactation treated cows produced:
   – 63 L more milk
   – 2.8 kg more protein
   – 2.8 kg more milk fat.

"The Power To Produce Your Best"

This Product is only licensed for sale in the Republic of Ireland

 

Click here to Download Data Sheet

Summary of Product Characteristics

1 NAME OF THE VETERINARY MEDICINAL PRODUCT

Elivec 5 mg/ml pour-on solution for cattle

2 QUALITATIVE AND QUANTITATIVE COMPOSITION

One ml of solution contains:

Active substance:

Eprinomectin  5.00 mg

Excipients:

Butylhydroxytoluene (E 321)  0.10 mg
All-rac-alpha-tocopherol (E 307)  0.06 mg

For the full list of excipients, see section 6.1.

3 PHARMACEUTICAL FORM

Pour-on solution.
Pale yellow to yellow clear solution.

4 CLINICAL PARTICULARS

4.1 Target Species


Cattle (beef and dairy cattle).

4.2 Indications for use, specifying the target species

Treatment of infestations by the following parasites sensitive to eprinomectin:

Cattle:
 - Warbles (parasitic stages):
Hypoderma bovis
Hypoderma lineatum

- Mange mites:
Chorioptes bovis
Sarcoptes scabiei var. Bovis

- Sucking lice:
Linognathus vituli
Haematopinus eurysternus
Solenopotes capillatus

- Biting lice:
Bovicola (Damalinia) bovis

-Horn flies:
Haematobia irritans

The product protects the animals against reinfestations with:
- Nematodirus helvetianus for 14 days.
- Trichostrongylus axei for 21 days.
- Dictyocaulus viviparus, Haemonchus placei, Cooperia oncophora, Cooperia punctata, Cooperia surnabada, Oesophagostomum radiatum and Ostertagia ostertagi for 28 days.

The duration of persistent efficacy can be variable for Cooperia spp and H. placei 14 days after treatment in particular in young and lean animals at the time of treatment.

4.3 Contraindications

Avermectins may not be well tolerated in non-target species (including dogs, cats and horses).
Cases of mortality are reported in dogs, especially Collies, bobtail and related breeds and crosses, and also in turtles/tortoises.
Do not use in other animal species.
Do not administer orally or by injection.
Do not use in cases of hypersensitivity to the active substance or to any of the excipients.

4.4 Special warnings for each target species

Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:
- Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
- Underdosing, which may be due to underestimation of bodyweight, misadministration of the product, or lack of calibration of the dosing device (if any).
Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.

To date no resistance to eprinomectin (a macrocyclic lactone) has been reported in cattle within the EU.

However, resistance to other macrocyclic lactones has been reported in parasite species in cattle within the EU.

Therefore, use of this product should be based on local (regional, farm) epidemiological information about susceptibility of nematodes and recommendations on how to limit further selection for resistance to anthelmintics.
If there is a risk for re- infection, the advice of a veterinarian should be sought regarding the need for and frequency of repeat administration.

For the best results the product should be part of a programme to control both internal and external parasites of cattle based on the epidemiology of these parasites. 

4.5 Special precautions for use Special precautions for use in animals

For external use only.
For effective use, the product should not be applied to areas of the backline covered with mud or manure.
The product should be applied only on healthy skin.
To avoid adverse reactions due to the death of warble larvae in the oesophagus or backbone, it is recommended to administer the product after the end of warble fly activity and before the larvae reach their resting sites in the body; consult a veterinary surgeon to know the appropriate treatment period.

Special precautions to be taken by the person administering the veterinary medicinal  product to animals

This product may be irritating to the skin and eyes and may cause hypersensitivity (allergic reactions).
Avoid contact with the skin and eyes during treatment and when handling recently treated animals.
People with known hypersensitivity to eprinomectin should avoid contact with the product.
Wear rubber gloves, boots and a waterproof coat when applying the product.
If accidental skin contact occurs, wash the affected area immediately with soap and water.
If accidental eye exposure occurs, flush the eyes immediately with water.
Should clothing become contaminated, remove as soon as possible and launder before re-use.
This product may affect the central nervous system if accidentally ingested.
Avoid accidental ingestion of the product, including by hand to mouth contact.
If ingestion does occur, wash the mouth out with water and seek medical advice.
Do not smoke, eat or drink while handling the product.
Wash hands after use.

Other precautions

Eprinomectin is very toxic to aquatic organisms, is persistent in soils and may accumulate in sediments.
Faeces containing eprinomectin excreted onto pasture by treated animals may temporarily reduce the abundance of dung feeding organisms.
Following treatment of cattle with the product, levels of eprinomectin that are potentially toxic to dung fly species may be excreted over a period of more than 4 weeks and may decrease dung fly abundance during that period.

In case of repeated treatments with eprinomectin (as with products of the same anthelmintic class) it is advisable not to treat animals every time on the same pasture to allow dung fauna populations to recover. 

Eprinomectin is inherently toxic to aquatic organisms.
The product should be used only according to the label instructions.
Based on the excretion profile of eprinomectin when administered as the pour-on formulation, treated animals should not have access to watercourses during the first 7 days after treatment.

4.6 Adverse reactions (frequency and seriousness)

In very rare cases, transient licking reactions, skin tremor at the administration site, minor local reactions such as the occurrence of dandruff and skin scales at the administration site have been observed.

The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reactions)
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports)

4.7 Use during pregnancy, lactation or lay

Laboratory studies (rat, rabbit) have not produced any evidence of a teratogenic or embryotoxic effects due to the use of eprinomectin at therapeutic doses.
The safety of the veterinary medicinal product in cattle has been established during pregnancy and lactation and in reproductive bulls.
Can be used during pregnancy and lactation as well as in reproductive bulls.

4.8 Interaction with other medicinal products and other forms of interaction

Since eprinomectin binds strongly to plasma proteins, this should be taken into account if it is used in association with other molecules having the same characteristics.

4.9 Amounts to be administered and administration route

Pour-on use.
To be administered topically in one single treatment at the dose rate of 500 μg eprinomectin per kg bodyweight equivalent to 1 ml per 10 kg bodyweight.
Apply the pour-on solution along the backline in a narrow strip extending from the withers to the tail head.
All the animals belonging to the same group should be treated at the same time.
To ensure administration of a correct dose, bodyweight should be determined as accurately as possible and accuracy of the dosing device should be checked.
If  animals are to be treated collectively rather than individually, they should be grouped according to their bodyweight and dosed accordingly, in order to avoid under- or over-dosing.

Method of Administration:

For the 1 litre presentation:

The bottle is equipped with an integrating dosing system, and has two openings.
One opening is connected to the body of the container and the other one to the dispensing chamber (dosing system). Unscrew the cap and remove the seal of the dispensing chamber (integrated dosing system graduated each 10 ml up to 50 ml).
Squeeze the bottle to fill the dispensing chamber with the required volume of product.

For the 2.5 L and 5 L presentations:

To be used with an appropriate dosing system such as a dosing gun and coupling vented cap.
Unscrew the polypropylene (PP) simple cap.
Remove the protective seal from the bottle.
Screw the coupling vented cap on the bottle and make sure it is tightened.
Connect the other side to a dosing gun.
Follow the gun manufacturer's instructions for adjusting the dose and proper use and maintenance of the dosing gun.

After use, coupling vented caps should be removed and replaced by PP simple cap.
Vented caps should be placed for a later use in the box.

4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary

No signs of toxicity have been observed after administration of up to 5 times the recommended dose.
No specific antidote has been identified.

4.11 Withdrawal period(s)

Meat and offal: 15 days.
Milk: zero hours.

5 PHARMACOLOGICAL or IMMUNOLOGICAL PROPERTIES

Pharmacotherapeutic group:
endectocides, macrocyclic lactones, avermectins.

ATCvet code:
QP54AA04. 

5.1 Pharmacodynamic properties

Eprinomectin is a molecule with an endectocidal activity belonging to the macrocyclic lactone class.
Compounds of the class bind with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve or muscle cells.
These compounds bind selectively to these channels, which leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite.
Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter GABA (gamma-aminobutyric acid).

5.2 Pharmacokinetic particulars 

The bioavailability of topically applied eprinomectin in cattle is about 30% with most absorption occurring by about 10 days after treatment.
Eprinomectin is strongly linked to plasma proteins (99%).
Eprinomectin is not extensively metabolized in cattle following topical administration.
Faeces are the major route of elimination.
Environmental properties Like other macrocyclic lactones, eprinomectin has the potential to adversely affect non-target organisms. See section 4.5 iii) other precautions.

6 PHARMACEUTICAL PARTICULARS

6.1 List of excipients


Butylhydroxytoluene (E321) all-rac-alpha-tocopherol (E307) Propylene glycol dicaprylocaprate

6.2 Major incompatibilities

In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.

6.3 Shelf-life Shelf life of the veterinary medicinal product as packaged for sale:
2 years Shelf life after first opening the immediate packaging:
18 months and before expiry date 

6.4 Special precautions for storage 1 L:
Keep the bottle in the outer carton in order to protect from light.

2.5 L and 5 L:

This veterinary medicinal product does not require any special storage conditions.

6.5 Nature and composition of immediate packaging

- Squeeze-measure pour-on system: 1 L natural high density polyethylene (HDPE) bottle with integrated measuring chamber graduated each 10 ml up to 50 ml, removable aluminium/PE seals and HDPE screw cap included in a cardboard box.
- Back pack: 2.5 L and 5 L white HDPE bottles with a removable (ethylene-methacrylic acid) zinc co-polymer seal, a polypropylene (PP) screw cap and a PP coupling vented cap included in a cardboard box.

Box of 1L bottle
Box of 2.5L bottle
Box of 5L bottle
Not all pack sizes may be marketed.

6.6 Special precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products

The veterinary medicinal product is dangerous for fish and aquatic organisms.
Do not contaminate surface waters or ditches with the product or used container.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

7 MARKETING AUTHORISATION HOLDER

LIVISTO Int'l,S.L.
Av. Universitat Autònoma, 29
08290 Cerdanyola des Vallès
Barcelona
E-08950
Spain

8 MARKETING AUTHORISATION NUMBER(S)

VPA10425/005/001 

9 DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION

Date of first authorisation: 25th May 2018

10 DATE OF REVISION OF THE TEXT

Cattle Pour-ons

These should be applied along the length of the flattest part of the animal’s back, from the withers to the tail head.
In general, animals should not be treated when the hair is wet or if rain is anticipated within two hours of treatment. However, some products are waterproof and can be used on wet animals.
Areas of damaged skin should be avoided, as should areas contaminated with mud or manure

 

Delivery Information

Delivery Service

Here at Agridirect we have joined forces with DPD to ensure all packages are delivered promptly and safely to you. We ship to all mainland countries within the EU. Deliveries take place Monday to Friday excluding bank holidays. Once your order has been dispatched from our warehouse you will be notified by email. If there is a delay with your order for any reason you will be contacted immediately. 

Due to Brexit we are temporarily unable to ship to the UK. Shipping to Northern Ireland will remain in place.

Delivery Times
Ireland (ROI & NI)EU (Mainland Only)
2-4 Working Days4-6 Working Days

Some product have an extended delivery time, this is noted on the products.

Delivery Rates

CountryOrders Under €99Orders Over €99
Ireland (ROI & NI)€6.99€0.00
Austria€19.99€13.00
Belgium€16.99€10.00
Czech Republic€19.99€13.00
Denmark€19.99€13.00
Finland€31.99€25.00
France€16.99€10.00
Germany€16.99€10.00
Hungary€23.99€17.00
Italy€29.99€23.00
Luxenburg€16.99€10.00
Netherlands€16.99€10.00
Poland€16.99€13.00
Portugal€31.99€25.00
Slovakia€23.99€17.00
Slovenia€23.99€17.00
Spain€29.99€23.00
Sweden€29.99€23.00

 

A selection of the products we sell are only licensed for sale within the Republic Of Ireland and can not be shipped outside of the country. These products are noted as only being available within the Republic of Ireland on the individual product pages.

There may be an addition charge on certain bulky items. This charge will be clearly marked on an applicable products and will be explained on the checkout page before payment has been made.

Agridirect Returns Policy

We’re sorry your purchase didn’t work out. But don’t worry; we have a great returns policy to help you out, plus returns are free.

All purchases can be returned to us within 14 days of delivery and returned goods must be received within 14 days from the date you informed us of the return.

Purchases may be opened for inspection but must not be used and must be repackaged securely in the original packaging if you wish to return it.
 

If we discover goods have been used or there has been a loss in value of the goods due to damage to the goods, while in your care or whilst being returned to us, we will reduce the amount refunded, which may amount to the full cost of the product, to cover loss of value of goods.

All returns should be complete which includes boxes, manuals and accessories that may have been included with the order.

All returns must be packaged appropriately for shipping, we will not accept responsibility for damages or loss which occur during shipping of a return product.

We accept no responsibility for goods damaged or lost while in transit to us. 

How do I return a product?

Making returns to us are free, simply follow the steps below and bring your package to an official DPD pickup point.

  • All returns must be accompanied with a fully filled out returns form which can be downloaded here.
  • To print off your return label click here or visit www.dpd.ie/returns and follow the on-screen instructions. Make sure and use your order number as your reference.
  • Bring your package to a DPD pickup point. To find your nearest drop off point here.

Once the returned product has been received into our warehouse and been fully inspected a refund will be issued.

For the return of bulk products please contact us at sales@agridirect.ie

I have received a damaged product from you, what should I do?

First off, if you have received a damaged electrical product from us, do not plug it in. Any electrical products that are plugged in are deemed ‘as used and accepted’ and are not accepted as returns. All damages must be reported to us via phone or email within 24hours of receipt of goods. Please ensure you check your items upon delivery.

How do I begin the returns process?

If you wish to begin the return process, please email us at sales@agridirect.ie and ensure the following information is included in your email. Your name, phone number, Order id, the item you wish to return, reason for return and if the product is damaged we require photos of the product.

Once you have sent us all required information a member of our team will assess your claim and will contact you as soon as possible. Please hold off on returning products until a member of our team has called you to confirm.

Refunds

Once the returned product has been returned to us and fully inspected a refund will be issued.

Please Note: A typical timeline for a refund to show in your account is up to 10 working days from the date processed, depending on your bank.

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