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Dectomax Injection (Doremectin)
Dectomax Injection (Doremectin)

Dectomax Injection (Doremectin)

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Dectomax Injection is used for the treatment and control of internal parasites such as gastro-intestinal round worms and lungworm and external parasites such as mites, lice and ticks in sheep, cattle and pigs. It also works as an effective preventative and cure for Scab. Dectomax Injection can be given to sheep via Intramuscular injection making it quick and easy to administer compared to other injections.

Active Ingredient: Doremectin

Target Species: Sheep, cattle and pigs

Administration Method: Subcutaneous injection (under the skin) for cattle, Intramuscular injection (directly into muscle) for sheep

Treats and Controls: gastrointestinal nematodes, lungworms, eyeworms, warbles, lice, mange mites and ticks in cattle, gastrointestinal roundworms, lungworms, mange mites and nasal bots in sheep

Withdrawal Time: 70 days for animals intended for meat and offal, not permitted for use on animals producing milk for human consumption.

Dosage for cattle: 1ml per 50 kg of bodyweight 

Body WeightDose VolumeNumber of full doses per pack:
50ml200ml500ml
50kg1 ml50200500
100kg2 ml25100250
150kg3 ml1666166
200kg4 ml1250125
250kg5 ml1040100
300kg6 ml83383
350kg7 ml72871
400kg8 ml62562
450kg9 ml52255
500kg10 ml52050
550kg11 ml41845
600kg12 ml41641

Dosage for sheep:0.5 ml per 15 kg of bodyweight 

Body WeightDose VolumeNumber of full doses per pack:
50ml200ml500ml
15kg0.5 ml1004001000
30kg1 ml50200500
45kg1.5 ml33133333
60kg2 ml25100250
75kg2.5 ml2080200

For cases of scab the rate differs slightly to 1ml per 33kg.

Key Features of Dectomax Injection

  • Treats and controls of internal parasites such as gastro-intestinal round worms and lungworm and external parasites such as mites, lice and ticks in sheep,
  • Used in both cattle and pigs.
  • An effective preventative and cure for Scab. 
  • Dectomax Injection can be given to sheep via Intramuscular injection making it quick and easy to administer compared to other injections.

Always read the label and all enclosed information for Dectomax injection before administering to animal

This product is only licensed for sale within the Republic of Ireland

Click here to Download Data Sheet

Health Products Regulatory Authority 

Summary of Product Characteristics 

1 NAME OF THE VETERINARY MEDICINAL PRODUCT
DECTOMAX 10 mg/ml Solution for Injection for Cattle, Sheep and Pigs

2 QUALITATIVE AND QUANTITATIVE COMPOSITION
Each ml contains:
Active Substance
Doramectin 10.0 mg

Excipients
Butylhydroxyanisole (E320) 0.1 mg
For the full list of excipients, see section 6.1

3 PHARMACEUTICAL FORM

Solution for injection.
Clear colourless, to pale yellow solution.

4 CLINICAL PARTICULARS

4.1 Target Species

Cattle, Sheep and Pigs

4.2 Indications for use, specifying the target species
CATTLE:

For treatment and control of gastrointestinal nematodes, lungworms, eyeworms, warbles, lice, mange mites and ticks.

Gastrointestinal roundworms (adults and fourth stage larvae):
Ostertagia ostertagi (including inhibited larvae)
O.lyrata *
Haemonchus placei
Trichostrongylus axei
T.colubriformis
Cooperia oncophora
C.pectinata 
C.punctata
C.surnabada (syn. mcmasteri)
N.spathiger *
Bunostomum phlebotomum *
Strongyloides papillosus *
Oesophagostomum radiatum
Trichuris spp. * * adults

Lungworms: (adults and fourth stage larvae)
Dictyocaulus viviparus

Eyeworms: (adults)
Thelazia spp. 

Warbles: (parasitic stages)
Hypoderma bovis
H.lineatum

Sucking lice:
Haematopinus eurysternus
Linognathus vituli
Solenopotes capillatus

Mange mites:
Psoroptes bovis
Sarcoptes scabiei
The product may also be used as an aid in the control of Nematodirus helvetianus, biting lice (Damalinia bovis), the tick Ixodes ricinus and the mange mite Chorioptes bovis.
Following product administration, efficacy against re-infection with the following parasites persists for the period indicated:
Species Days
Bunostomum phlebotomum 22
Cooperia oncophora 21
Dictyocaulus viviparous 35
Haemonchus placei (adults only) 28
Linognathus vituli 28
Oesophagostomum radiatum 21
Ostertagia ostertagi 35
Psoroptes bovis 42
Trichostrongylus axei 28 

SHEEP:
For treatment and control of gastrointestinal roundworms, mange mites and nasal bots.

Gastrointestinal roundworms (Adults and fourth stage larvae (L4) unless otherwise indicated):
Bunostomum trigonocephalum (Adults only)
Chabertia ovina
Cooperia curticei (L4 only)
C.oncophora
Gaigeria pachyscelis
Haemonchus contortus
Nematodirus battus (L4 only)
N.filicollis (Adults only)
N.spathiger
Ostertagia (Teladorsagia) circumcincta*
Ostertagia (Teladorsagia) trifurcata (Adults only)
Oesophagostomum venulosum (Adults only)
O.columbianum
Strongyloides papillosus
Trichostrongylus axei
T.colubriformis
T.vitrinus
Trichuris spp. (Adults only)
*Inhibited larval stages (L4), including strains that are benzimidazole resistant, are also controlled.

Lungworms (Adults and fourth stage larvae (L4))
Cystocaulus ocreatus (Adults only)
Dictyocaulus filaria
Muellerius capillaris (Adults only)
Neostrongylus linearis (Adults only)
Protostrongylus rufescens (Adults only) 

Nasal bots (1st, 2nd and 3rd instar larvae)
Oestrus ovis

Mange mites
Psoroptes ovis

PIGS:
For treatment of mange mites, gastrointestinal roundworms, lungworms, kidney worms and sucking lice in pigs.

Gastrointestinal nematodes (adults and fourth stage larvae)
Hyostrongylus rubidus
Ascaris sum
Strongyloides ransomi (adults only)
Oesophagostomum dentatum
Oesophagostomum quadrispinulatum

Lungworms
Metastrongylus spp. (adults only)

Kidney worms Stephanurus dentatus (adults only)

Sucking Lice Haematopinus suis

Mange Mites Sarcoptes scabiei
The product protects pigs against infection or reinfection with Sarcoptes scabiei for 18 days.

4.3 Contraindications
Do not use in dogs, as severe adverse reactions may occur.
In common with other avermectins, certain breeds of dog, such as collies, are especially sensitive to doramectin and particular care should be taken to avoid accidental consumption of the product. See section 4.5 i.

Do not use in case of hypersensitivity to the active substance or any of the excipients.

4.4 Special warnings for each target species
Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:
- too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
- under dosing, which may be due to underestimation of bodyweight, misadministration of the product, or lack of calibration of a dosing device (if any).
Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. faecal egg count reduction test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to a different pharmacological class and having a different mode of action should be used.
Resistance to avermectins has been reported in Teladorsagia and Haemonchus in sheep within the EU.
Therefore, the use of this product should be based on local (regional, farm) epidemiological information about susceptibility of nematodes and recommendations on how to limit further selection for resistance to anthelmintics.

4.5 Special precautions for use
Special precautions for use in animals

Avermectins may not be well tolerated in all non-target species.
Cases of intolerance with fatal outcome are reported in dogs, especially Collies, Old English Sheepdogs and related breeds or crosses, and also in turtles/tortoise.
Care should be taken to avoid ingestion of spilled product or access to containers by these other species.
When treating groups of animals, use a suitable automatic dosing device and vented draw-off apparatus.

For treatment of individual pigs, the use of appropriate sized needles and disposable syringes should be advised by a veterinarian. 

For the treatment of piglets weighing 16 kg or less, a 1 ml disposable syringe graduated in increments of 0.1 ml or less should be used.
Use sterile equipment and follow aseptic procedures.
Avoid the introduction of contamination.
Vial stoppers must not be broached more than one time.
Swab the septum before removing each dose.

Special precautions to be taken by the person administering the veterinary medicinal product to animals
Do not smoke or eat while handling the product.
Wash hands after use.
Take care to avoid accidental self-administration – seek medical attention should any specific signs be noticed. Advice to medical practitioners:
In case of accidental self injection specific symptoms have rarely been observed and therefore any cases should be treated symptomatically.

Other precautions
Doramectin is very toxic to dung fauna and aquatic organisms and may accumulate in sediments.
The risk to aquatic ecosystems and dung fauna can be reduced by avoiding too frequent and repeated use of doramectin (and products of the same anthelmintic class) in cattle and sheep.
The risk to aquatic ecosystems will be further reduced by keeping treated cattle away from water bodies for two to five weeks after treatment.
 

4.6 Adverse reactions (frequency and seriousness)
None.


4.7 Use during pregnancy, lactation or lay
May be used in pregnant cows and ewes.
The product is indicated for use in breeding and lactating sows and in breeding boars.

4.8 Interaction with other medicinal products and other forms of interactions
None known.

4.9 Amounts to be administered and administration route
For the treatment and control of gastrointestinal roundworms, lungworms, eyeworms, warbles, lice and mange mites in cattle, and gastrointestinal roundworms and nasal bots in sheep, a single treatment of 1 ml (10 mg Doramectin) per 50 kg bodyweight, equivalent to 200 mcg/kg bodyweight, administered in the region of the neck by subcutaneous injection in cattle and by intramuscular injection in sheep. 

For the treatment of clinical signs of Psoroptes ovis (sheep scab) and elimination of living mites on sheep a single treatment of 1 ml per 33 kg bodyweight, equivalent to 300 mcg/kg bodyweight, administered in the neck by intramuscular injection. 

In addition, adequate bio-security measures should be implemented to prevent reinfestation. 
It is important to ensure that all sheep which have been in contact with infested sheep are treated.
For the treatment of Sarcoptes scabei and gastrointestinal nematodes, lungworms, kidney worms and sucking lice in pigs, a single treatment of 1 ml per 33 kg bodyweight, equivalent to 300 mcg/kg bodyweight, administered by intramuscular injection.

Piglets weighing 16 kg or less should be dosed in accordance with the following table:
Body weight (kg)            Dose (ml)
Less than 4 kg                  0.1 ml
5 - 7 kg                             0.2 ml
8 - 10 kg                           0.3 ml
11 - 13 kg                         0.4 ml
14 - 16 kg                         0.5 ml

To ensure administration of a correct dose, bodyweight should be determined as accurately as possible; accuracy of the dosing device should be checked.
If animals are to be treated collectively rather than individually, they should be grouped according to their bodyweight and dosed accordingly, in order to avoid under- and over- dosing.

Maximum injection volume for each target species:
Cattle: 5 ml per injection site
Sheep:1.5 ml per injection site
Pigs: 2.5 ml per injection site

The product may be used with automatic injection equipment with a vented draw-off system.
Vial stoppers must not be broached more than one time.

4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
In cattle, sheep and pigs overdoses up to 25, 10 and 10 times the maximum label recommended dose, respectively, resulted in no adverse clinical signs.

4.11 Withdrawal period(s)
CATTLE: Meat and offal: 70 days
Not permitted for use in lactating animals producing milk for human consumption.
Do not use in pregnant cows or heifers, which are intended to produce milk for human consumption, within 2 months of expected parturition. 

SHEEP:
Meat and offal: 70 days
Not permitted for use in lactating animals producing milk for human consumption.
Do not use in pregnant ewes, which are intended to produce milk for human consumption, within 70 days of expected parturition. 

PIGS:
Meat and offal: 77 days

5 PHARMACOLOGICAL or IMMUNOLOGICAL PROPERTIES
Pharmacotherapeutic group:

macrocyclic lactones,
avermectins

ATCvet Code:
QP 54AA03

5.1 Pharmacodynamic properties
Doramectin is an antiparasitic agent, isolated from fermentation of selected strains derived from the soil organism Streptomyces avermitilis.
It is a macrocyclic lactone and is closely related to ivermectin. 
Both compounds share a wide spectrum of antiparasitic activity and produce a similar paralysis in nematodes and parasitic arthropods.
Macrocyclic lactones activate glutamate gated chloride channels (GluCl) found on muscle membranes of the pharynx and particular neurones of invertebrate parasites. 
The selective toxicity of the macrocyclic lactones as antiparasitics is attributed to this action on channels that are not present in the host animal. 
There is evidence that the membranes of the muscle cells of the invertebrate female reproductive tract may be more sensitive to macrocyclic lactones than receptors on nerve or other muscle and this may explain the dramatic but temporary reduction in egg production in parasites not killed or eliminated by drug therapy.

5.2 Pharmacokinetic particulars
Maximum plasma concentration of Doramectin occurs in 3 days with an elimination half-life of around 6 days in cattle, following subcutaneous administration.
Maximum plasma concentration of Doramectin occurs in 2 days with an elimination half-life of 4.5 days in sheep, following either subcutaneous or intramuscular administration.
Maximum plasma concentration of Doramectin occurs in 3 days with an elimination half-life of around 6 days in pigs, following intramuscular administration.

5.3 Environmental properties
Like other macrocyclic lactones, doramectin has the potential to adversely affect non-target organisms.
Following treatment, excretion of potentially toxic levels of doramectin may take place over a period of several weeks. Faeces containing doramectin excreted onto pasture by treated animals may reduce the abundance of dung feeding organisms which may impact on the dung degradation.
Doramectin is very toxic to aquatic organisms and may accumulate in sediments.

6 PHARMACEUTICAL PARTICULARS
6.1 List of excipients

Ethyl Oleate Sesame oil Butylhydroxyanisole (E320)

6.2 Major incompatibilities
In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.

6.3 Shelf-life
Shelf life of the veterinary medicinal product as packaged for sale: 3 years.
Shelf life after first opening the immediate container: 28 days.

6.4 Special precautions for storage
Do not store above 30 °C.
Protect from direct sunlight – do not remove from the protective plastic overwrap.

6.5 Nature and composition of immediate packaging
The product is supplied in 50 ml, 200 ml and 500 ml multi-dose Type II or Type III amber glass vials with chlorobutyl rubber stoppers and aluminium overcaps or in 250 ml multi-dose Type II amber glass vials with chlorobutyl rubber stoppers and aluminium overcaps.  
Not all pack sizes may be marketed.

6.6 Special precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products
Extremely dangerous for fish and aquatic life. 
Do not contaminate ponds, waterways or ditches with the product or used container.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

7 MARKETING AUTHORISATION HOLDER
Zoetis Belgium S.A.
2nd Floor,
Building 10
Cherrywood Business Park,
Loughlinstown
Co Dublin
Ireland

8 MARKETING AUTHORISATION NUMBER(S)
VPA10387/019/001

9 DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION
Date of first authorisation: 17th August 2012
Date of last renewal: 14th October 2016

10 DATE OF REVISION OF THE TEXT
August 2020

 Cattle Injectables
Injectables should be given according to the manufacturer’s instructions at the recommended injection site.
• Always use a clean, sterile syringe and needle. If using a multiple injection gun, ensure the needle is disinfected between injections, e.g. with an automatic sterilisation system.
• If the site to be injected is dirty, clean the skin and swab with an alcohol-impregnated wipe or cotton wool.
• Before injecting, check the expiry date and read the instructions of the product to be used. Some products need to be shaken before use.
• Use the correct-sized needle according to the size of the animal and site of injection.
• Ensure the animal is adequately restrained before attempting the injection.
• Take care to ensure it is given subcutaneously and not intramuscularly. Raise a fold of skin at the injection site (mainly neck but some are ear) recommended by the product manufacturer and inject carefully into the space created.
• If a large dose is to be delivered, it may be advisable to split the dose between two injection sites. After the injection, briefly massage the site to improve the dispersal of the injected material.
• Dispose of the needle and syringe in appropriate clinical waste and sharps containers.

Sheep Subcutaneous injections
Subcutaneous injections need to be administered with care to ensure the product is placed under the skin and not into the fleece or muscle.
The sheep needs to be well restrained, and the skin ‘tented’ away from the underlying muscle.
The preferred injection site is 10–15 cm (4–6 inches) below the ear on the side of the neck (see diagram below). Usually a 1.6 cm (5/8 inch) needle is ideal.
After administration, the site should be gently massaged.

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A selection of the products we sell are only licensed for sale within the Republic Of Ireland and can not be shipped outside of the country. These products are noted as only being available within the Republic of Ireland on the individual product pages.

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Agridirect Returns Policy

We’re sorry your purchase didn’t work out. But don’t worry; we have a great returns policy to help you out, plus returns are free.

All purchases can be returned to us within 14 days of delivery and returned goods must be received within 14 days from the date you informed us of the return.

Purchases may be opened for inspection but must not be used and must be repackaged securely in the original packaging if you wish to return it.
 

If we discover goods have been used or there has been a loss in value of the goods due to damage to the goods, while in your care or whilst being returned to us, we will reduce the amount refunded, which may amount to the full cost of the product, to cover loss of value of goods.

All returns should be complete which includes boxes, manuals and accessories that may have been included with the order.

All returns must be packaged appropriately for shipping, we will not accept responsibility for damages or loss which occur during shipping of a return product.

We accept no responsibility for goods damaged or lost while in transit to us. 

How do I return a product?

Making returns to us are free, simply follow the steps below and bring your package to an official DPD pickup point.

  • All returns must be accompanied with a fully filled out returns form which can be downloaded here.
  • To print off your return label click here or visit www.dpd.ie/returns and follow the on-screen instructions. Make sure and use your order number as your reference.
  • Bring your package to a DPD pickup point. To find your nearest drop off point here.

Once the returned product has been received into our warehouse and been fully inspected a refund will be issued.

For the return of bulk products please contact us at sales@agridirect.ie

I have received a damaged product from you, what should I do?

First off, if you have received a damaged electrical product from us, do not plug it in. Any electrical products that are plugged in are deemed ‘as used and accepted’ and are not accepted as returns. All damages must be reported to us via phone or email within 24hours of receipt of goods. Please ensure you check your items upon delivery.

How do I begin the returns process?

If you wish to begin the return process, please email us at sales@agridirect.ie and ensure the following information is included in your email. Your name, phone number, Order id, the item you wish to return, reason for return and if the product is damaged we require photos of the product.

Once you have sent us all required information a member of our team will assess your claim and will contact you as soon as possible. Please hold off on returning products until a member of our team has called you to confirm.

Refunds

Once the returned product has been returned to us and fully inspected a refund will be issued.

Please Note: A typical timeline for a refund to show in your account is up to 10 working days from the date processed, depending on your bank.

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