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Cydectin Triclamox Pour-On (Moxidectin, Triclabendazole)
Cydectin Triclamox Pour-On (Moxidectin, Triclabendazole)
Cydectin Triclamox Pour-On (Moxidectin, Triclabendazole)

Cydectin Triclamox Pour-On (Moxidectin, Triclabendazole)

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Delivery Time: 5-6 Days
Information

Cydectin Triclamox Pour-on is a broad spectrum flukicide and wormer for cattle. It is used for the treatment and control of gastro-intestinal worms, lungworms,  liver fluke and roundworms in beef cattle.

Active Ingredient: Moxidectin, Triclabendazole

Target Species: Cattle

Treats and Controls: Gastro-intestinal worms, lungworms,  liver fluke and roundworms

Administration Method: Pour On

Withdrawal Time: 143 days for animals intended for meat and offal, not permitted for use on animals producing milk for human consumption.

Dosage: 1 ml per 10 kg of bodyweight

Body WeightDose VolumeNumber of full doses per pack:
500ml1 Litre2.5 Litre5 Litre
50kg5 ml1002005001000
100kg10 ml50100250500
150kg15 ml3366166333
200kg20 ml2550125250
250kg25 ml2040100200
300kg30 ml163383166
350kg35 ml142871142
400kg40 ml122562125
450kg45 ml112255111
500kg50 ml102050100
550kg55 ml9184590
600kg60 ml8164183

Always read the label and all enclosed information for Cydectin Triclamoc Pour-On before administering to animals!

 

Key Features of Cydectin Triclamox Pour-on

  • Contains moxidectin: established as an effective broad spectrum wormer with high potency
  • Contains triclabendazole: established as the flukicide with activity against the widest range of fluke maturity
  • Pour-On formulation
  • Rainfast: Rainfall immediately before or within 2 hours after treatment will not affect the efficacy of the product

Key Benefits

  • Controls liver fluke and roundworms in a single treatment
  • Using a flukicide active against immature fluke:
  • Helps to ensure that fewer fluke continue to develop into adults after treatment
  • Helps to maximise the production benefits of fluke control
  • Means that treatment can be applied sooner after autumn/winter housing
  • Reduces the need for re-treatment later in the winter or the following spring
  • Easy to use, saving time and money

Cydectin Triclamoc Pour-on Comparative efficacy against fluke.

Objectives:To Evaluate the efficacy of Cydectin Triclamox Pour-on for Cattle against 4,6 and 8 week old immature and 12 week old adult stages of liver fluke (Fasciola Hepatica) in cattle compared to untreated controls and treatment with other commercially available products.

Method: 104 Holstein-Friesian calves were divided into groups and infected with liver fluke metacercariae on day 0. While one group remained untreated the other groups received either Cydectin Triclamox Pour-on, ivermectin plus closantel pour-on or ivermectin plus clorsulon injection as treatment.

Treatments were given 4, 6, 8 or 12 weeks after infection and flukes were counted 14 to 15 weeks after infection.

Results:

Cydectin Triclamox treated cattle had significantly lower fluke count than untreated cattle. Cydectin Triclamox also  showed significantly higher effectivness against 4, 6 and 8 week old fluke than either of the other treatments.

This product is only licensed for sale within the Republic of Ireland

Data Sheet

Summary of Product Characteristics

1 NAME OF THE VETERINARY MEDICINAL PRODUCT
Cydectin TriclaMox 5 mg/ml + 200 mg/ml Pour-on Solution for cattle.

2 QUALITATIVE AND QUANTITATIVE COMPOSITION
For a full list of excipients, see section 6.1.
Each ml contains:
Active substances
Moxidectin 5.0 mg
Triclabendazole 200.0 mg
Excipients
Butylhydroxytoluene (E321) 5.0 mg

3 PHARMACEUTICAL FORM
Pour-on solution.
A clear, amber liquid.

4 CLINICAL PARTICULARS

4.1 Target Species
Cattle.
Each ml contains:
Active substances
Moxidectin 5.0 mg
Triclabendazole 200.0 mg
Excipients
Butylhydroxytoluene (E321) 5.0 mg

4.2 Indications for use, specifying the target species
In cattle:
Treatment of mixed trematode (fluke) and nematode infections and certain arthropod infestations caused by
moxidectin and triclabendazole sensitive strains:
The product has a persistent effect in preventing re-infection by Ostertagia ostertagi and by Dictyocaulus viviparus for
5 weeks after a single dose.

4.3 Contraindications
Do not use in cases of known hypersensitivity to the active substance(s) or to any of the excipient(s).
Parasite Adult stage Inhibited stages
NEMATODES L4
Gastro-intestinal nematodes:
Haemonchus placei  
Ostertagia ostertagi   
Trichostrongylus axei  
Nematodirus helvetianus  
Cooperia oncophora  
Cooperia punctata 
Oesophagostomum radiatum 
Bunostomum phlebotomum 
Respiratory tract nematode:
Dictyocaulus viviparus 
TREMATODES
Liver fluke: 6 - 8 weeks
immatures
Fasciola hepatica  
ECTOPARASITES
Linognathus vituli 
Bovicola bovis 
Solenopotes capillatus 

4.4 Special warnings for each target species
Care should be taken to avoid the following practices because they increase the risk of development of resistance and
could ultimately result in ineffective therapy:
• Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
• Underdosing, which may be due to underestimation of body weight, misadministration of the product, or lack
of calibration of the dosing device (if any).
Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal
Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an
anthelmintic belonging to another pharmacological class and having a different mode of action should be used.
In 2010, no confirmed resistance to moxidectin in cattle parasites has been reported in Europe, however, resistance to
other macrocyclic lactones (MLs) has been reported mainly in Cooperia oncophora in some European countries, and
resistance to moxidectin has been reported in the Southern Hemisphere. Resistance to other MLs in some strains of
Cooperia spp. can imply concurrent resistance to Moxidectin. Resistance to triclabendazole has been reported in
Fasciola hepatica in cattle in some European countries. Triclabendazole resistant F. hepatica hosted in sheep can be
transferred to cattle grazing the same pasture. Therefore the use of this product should be based on local (regional,
farm) epidemiological information about susceptibility of parasites, local history of treatments and recommendations
on how to limit further selection for resistance to anthelmintics.
This product should not be used for the treatment of single infections.
It has been shown that rainfall immediately before or within 2 hours after treatment will not affect the efficacy of the
product.

4.5 Special precautions for use
i. Special precautions for use in animals
This product has been formulated specifically for pour-on administration for cattle and must not be given by any other
route of administration or to any other species.
All animals in a group should be treated.
ii. Special precautions to be taken by the person administering the veterinary medicinal product to
animals
Wear gloves, protective work clothing and safety glasses when using the product
Do not smoke, drink or eat while handling the product.
Avoid direct contact with skin and eyes
Wash hands after use
If splashed in the eye or on the skin, wash with plenty of clean, running water immediately.
People with known hypersensitivity to the active substance should not handle the product. If irritation persists, seek
medical advice and show the label to the doctor.

4.6 Adverse reactions (frequency and seriousness)
None known.

4.7 Use during pregnancy, lactation or lay
The product is safe for use in pregnant and lactating animals.

4.8 Interaction with other medicinal products and other forms of interaction
None known.

4.9 Amounts to be administered and administration route
For external use only.
0.5 mg moxidectin/kg body weight and 20 mg triclabendazole/kg body weight (equivalent to 1 ml of solution for 10 kg)
and as a single topical application.
To be administered directly to the hair and skin along the midline of the back of the animal from the withers to the tail
head.
Apply to clean healthy skin.
To ensure administration of a correct dose, bodyweight should be determined as accurately as possible; accuracy of the
dosing device should be checked. If animals are to be treated collectively rather than individually, they should be
grouped according to their bodyweight and dosed accordingly, in order to avoid under- or overdosing.
Shake before use.
Directions for using the Squeeze-Pour System (500 ml and 1 litre bottles only) :
Step 1: Remove screw cap from dispensing chamber only. Remove foil seal.
Step 2: Gently squeeze the bottle to fill the measuring chamber with the required amount of liquid.
Step 3: Pour the measured volume of fluid from the chamber onto the animal as directed.
Repeat steps 2 and 3 for subsequent animals
Step 4: Reapply the screw cap to the dispensing chamber after use.
Directions for using a pour-on applicator (2.5 and 5 litre backpack):
Connect the pour-on applicator to the backpack as follows:
Attach the open end of the draw-off tubing to the cap with the stem.
Replace shipping cap with the cap that has the draw-off tubing. Tighten the draw-off cap.
Gently prime the pour-on applicator, checking for leaks.
Follow manufacturer’s directions for correct use and care of equipment.

4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
Signs of overdoses have not been seen at 5 times the recommended dose. However, if they do occur they should
be consistent with the mode of action of moxidectin and would be manifested as transient salivation, depression,
drowsiness and ataxia. Treatment is not generally necessary and recovery is generally complete within 24 to 48 hours.
There is no specific antidote.

4.11 Withdrawal Period(s)
Meat and offal: 143 days
Milk: Do not use in cattle of any age intended to produce milk for human consumption.
Due to the significant likelihood of cross-contamination of non-treated animals with this product due to grooming
(licking), treated animals should be housed separately from non-treated animals throughout the withdrawal period.
Non-compliance with this recommendation may lead to residues violations in non-treated animals.

5 PHARMACOLOGICAL or IMMUNOLOGICAL PROPERTIES
Pharmacotherapeutic group: antiparasitic product, endectocides
ATC vet code: QP54AB52, moxidectin combination

5.1 Pharmacodynamic properties
Moxidectin is an endectocide active against a wide range of internal and external parasites and is a second generation
macrocyclic lactone of the milbemycin family. Its principal mode of action is interfering with neuromuscular
transmission of the GABA (gamma amino butyric acid)-gated or glutamate-gated chloride channels. Moxidectin
stimulates the release of GABA and increases its binding to the postsynaptic receptors, and binds to the glutamategated
chloride channels. The net effect is to open the chloride channels on the postsynaptic junction to allow the inflow
of chloride ions and induce an irreversible resting state. This results in flaccid paralysis and eventual death of parasites
exposed to the drug.
Triclabendazole is a flukicide belonging to the benzimidazole group of anthelmintics. It is well established that
benzimidazole anthelmintics selectively bind to -tubulin, thus causing the depolymerisation of microtubules and the
subsequent disruption of microtubule-based processes in helminths.

5.2 Pharmacokinetic properties
Moxidectin is distributed throughout the body tissues but due to its lipophilicity the highest drug concentrations are
obtained in fat tissue. Moxidectin undergoes biotransformation by hydroxylation. The only significant route of
excretion is the faeces. The main pharmacokinetic parameters of moxidectin when administered as pour-on in the final
combined formulation of this product were the following: AUClast 50.9 ng.d.mL-1, Cmax 4.69 ng.mL-1, Tmax 8.7 d,
MRT 10.74 d .
The majority of the oral dose of triclabendazole in rats, sheep, goats and rabbits is eliminated in faeces after 6-10 days,
as unchanged drug or products of biliary excretion. Urinary excretion is minimal. Sulphone, sulphoxide, ketone and 4-
hydroxy triclabendazole derivatives are the main metabolites identified in plasma. Plasma kinetic studies of sulfoxide
and sulfone derivatives in various species after oral administration showed the sulfoxide to predominate in rabbits,
sheep and humans, and the sulfone in the horse, dog and cattle. The main pharmacokinetic parameters of
triclabendazole sulfoxide when administered in the final combined formulation of this product were: AUClast 26.9
μg.h.mL-1, Cmax 2.92 μg.mL-1, Tmax 3.3 d, MRT 9.72 d. The main pharmacokinetic parameters of triclabendazole
sulfone when administered in the final combined formulation were: AUClast 110.2 μg.h.mL-1, Cmax 7.78 μg. mL-1,
Tmax 12.9 d, MRT 12.98 d.

6 PHARMACEUTICAL PARTICULARS
6.1 List of excipients
Butylhydroxytoluene (E321)
-Hexalactone
Cineole
Caprylocaproyl Macrogolglycerides

6.2 Incompatibilities
In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary
medicinal products.

6.3 Shelf-life
Shelf-life of the veterinary medicinal product as packaged for sale: 2 years.
Shelf-life after first opening the immediate packaging: 6 months.

6.4 Special precautions for storage
Do not store above 25°C.
Protect from light.
Do not freeze.
If accidentally frozen, shake vigorously before use.

6.5 Nature and composition of immediate packaging
0.5, 1, 2.5 and 5 litre HDPE containers with polypropylene screw cap and polyethylene inner seal.

6.6 Special precautions for the disposal of unused veterinary medicinal products or waste materials
The product should not enter water courses as this may be dangerous for fish and other aquatic organisms.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be
disposed of in accordance with local requirements.

7 MARKETING AUTHORISATION HOLDER
Zoetis Ireland Limited
25/28 North Wall Quay
Dublin 1
Ireland


8 MARKETING AUTHORISATION NUMBER(S)
VPA 10438/019/001

9 DATE OF THE FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION
5th April 2012

10 DATE OF REVISION OF THE TEXT
January 2014

Delivery

 

Delivery Information

Here at Agridirect we have joined forces with DPD to ensure all packages are delivered promptly and safely to you. We ship to all mainland countries within the EU. Deliveries take place Monday to Friday excluding bank holidays. Once your order has been dispatched from our warehouse you will be notified by email. If there is a delay with your order for any reason you will be contacted immediately. 

Delivery Times
Ireland (ROI & NI)United Kingdom (Mainland Only)EU (Mainland Only)
1-3 Working Days2-4 Working Days4-6 Working Days

Some product have an extended delivery time, this is noted on the products.

Delivery Rates

Delivery Rates
CountryOrders Under €70Orders Over €70
Ireland (ROI & NI)€4.99€0.00
Austria€17.99€13.00
Belgium€14.99€10.00
Czech Republic€17.99€13.00
Denmark€17.99€13.00
Finland€29.99€25.00
France€14.99€10.00
Germany€14.99€10.00
Hungary€21.99€17.00
Italy€27.99€23.00
Luxenburg€14.99€10.00
Netherlands€14.99€10.00
Poland€14.99€13.00
Portugal€29.99€25.00
Slovakia€21.99€17.00
Slovenia€21.99€17.00
Spain€27.99€23.00
Sweden€27.99€23.00
United Kingdom (Mainland Only)€14.99€10.00

 

 

A selection of the products we sell are only licensed for sale within the Republic Of Ireland and can not be shipped outside of the country. These products are noted as only being available within the Republic of Ireland on the individual product pages

There may be an addition charge on certain bulky items. This charge will be clearly marked on an applicable products and will be explained on the checkout page before payment has been made.

 

Returns

Returns Policy

We’re sorry your purchase didn’t work out. But don’t worry; we have a great returns policy to help you out.
 

All purchases can be returned to us within 14 days of delivery and returned goods must be received within 14 days from the date you informed us of the return.
 

Purchases may be opened for inspection but must not be used and must be repackaged securely in the original packaging if you wish to return it.
 

If we discover goods have been used or there has been a loss in value of the goods due to damage to the goods, while in your care or whilst being returned to us, we will reduce the amount refunded, which may amount to the full cost of the product, to cover loss of value of goods.
 

We accept no responsibility for goods damaged or lost while in transit to us. 
 

The cost of the return, including all packaging and freight, lies solely with the consumer.
 

I have received a damaged product from you, what should I do?

First off, if you have received a damaged electrical product from us, do not plug it in. Any electrical products that are plugged in are deemed ‘as used and accepted’ and are not accepted as returns. All damages must be reported to us via phone or email within 24hours of receipt of goods. Please ensure you check your items upon delivery.

How do I begin the returns process?

If you wish to begin the return process, please email us at sales@agridirect.ie and ensure the following information is included in your email. Your name, phone number, Order id, the item you wish to return, reason for return and if the product is damaged we require photos of the product.

Once you have sent us all required information a member of our team will assess your claim and will contact you as soon as possible. Please hold off on returning products until a member of our team has called you to confirm.

 

Packaging

All returns must be the complete product which includes boxes, manuals and accessories that may have been include with the order.

All returns must be packaged appropriately for shipping, we will not accept responsibility for damages or loss which occur during shipping of a return product.
 

Address: Please ship the product to the following address: Agridirect, Drumrahan Retail, Church Street, Ballyconnell, Co Cavan
 

Refunds

Once the returned product has been returned to us and fully inspected a refund will be issued.

Please Note: A typical timeline for a refund to show in your account is up to 10 working days from the date processed, depending on your bank.

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