Curafluke 5% Oral Drench for Cattle and Sheep
Curafluke 5% Oral Drench is a broad-spectrum flukicide and wormer containing fenbendazole 50 mg/ml and rafoxanide 50 mg/ml, developed for use in cattle and sheep.
It provides three-way activity against liver fluke, gastrointestinal worms and lungworms, as well as activity against susceptible tapeworms.
Curafluke 5% treats mature liver fluke and immature fluke over eight weeks old. It is a practical option for farms managing worm and fluke burdens in cattle and sheep, particularly where livestock graze wet or fluke-prone land.
Product Information
| Curafluke 5% Product Details | |
|---|---|
| Active Ingredients | Fenbendazole 50 mg/ml and Rafoxanide 50 mg/ml |
| Target Species | Cattle and Sheep |
| Treats and Controls | Susceptible gastrointestinal roundworms, lungworms, tapeworms and mature and immature liver fluke over eight weeks old |
| Administration Method | Oral drench |
| Cattle Dosage | 11.25 ml per 50 kg bodyweight |
| Sheep Dosage | 1.5 ml per 10 kg bodyweight |
| Pack Sizes | 1 Litre, 2.5 Litre and 5 Litre |
| Cattle Meat Withdrawal | 60 days |
| Sheep Meat Withdrawal | 54 days |
| Milk Restriction | Not authorised for use in animals producing milk for human consumption |
| Irish Licence Number | VPA10990/032/001 |
Withdrawal Periods
| Species | Meat & Offal | Milk |
|---|---|---|
| Cattle | 60 days | Not authorised for use in animals producing milk for human consumption |
| Sheep | 54 days | Not authorised for use in animals producing milk for human consumption |
Important: Do not use in animals producing milk for human consumption, including during the dry period. Do not use during the last trimester of pregnancy in heifers intended for milk production. Do not use within one year before first lambing in ewes intended to produce milk for human consumption.
Curafluke 5% Dosage for Cattle
Recommended Dose: 11.25 ml per 50 kg bodyweight, providing 11.25 mg/kg of each active ingredient.
Administer orally using properly calibrated dosing equipment. Shake well before use.
Cattle - Dose and Bottle Coverage
| Weight | Dose | 1 L | 2.5 L | 5 L |
|---|---|---|---|---|
| 50 kg | 11.25 ml | 88 | 222 | 444 |
| 100 kg | 22.5 ml | 44 | 111 | 222 |
| 150 kg | 33.75 ml | 29 | 74 | 148 |
| 200 kg | 45 ml | 22 | 55 | 111 |
| 250 kg | 56.25 ml | 17 | 44 | 88 |
| 300 kg | 67.5 ml | 14 | 37 | 74 |
| 350 kg | 78.75 ml | 12 | 31 | 63 |
| 400 kg | 90 ml | 11 | 27 | 55 |
| 450 kg | 101.25 ml | 9 | 24 | 49 |
| 500 kg | 112.5 ml | 8 | 22 | 44 |
| 550 kg | 123.75 ml | 8 | 20 | 40 |
| 600 kg | 135 ml | 7 | 18 | 37 |
Curafluke 5% Dosage for Sheep
Recommended Dose: 1.5 ml per 10 kg bodyweight, providing 7.5 mg/kg of each active ingredient.
Administer orally using properly calibrated dosing equipment. Shake well before use.
Sheep - Dose and Bottle Coverage
| Weight | Dose | 1 L | 2.5 L | 5 L |
|---|---|---|---|---|
| 10 kg | 1.5 ml | 666 | 1666 | 3333 |
| 20 kg | 3 ml | 333 | 833 | 1666 |
| 30 kg | 4.5 ml | 222 | 555 | 1111 |
| 40 kg | 6 ml | 166 | 416 | 833 |
| 50 kg | 7.5 ml | 133 | 333 | 666 |
| 60 kg | 9 ml | 111 | 277 | 555 |
| 70 kg | 10.5 ml | 95 | 238 | 476 |
Bottle Coverage: Figures show the number of complete doses per bottle, rounded down and assuming no product wastage. Calculate doses using accurate bodyweights and properly calibrated dosing equipment.
Alternative Cattle Dosage After Housing
The supplied SPC also specifies a lower dose for cattle treated two months after housing when dosing for worms and adult liver fluke.
Lower Dose: 7.5 ml per 50 kg bodyweight, equivalent to 7.5 mg/kg of each active ingredient.
Examples: 200 kg cattle require 30 ml; 500 kg cattle require 75 ml.
Important: This lower dose is specified for the particular treatment situation described in the SPC. It should not be substituted for the standard dose when treatment of immature liver fluke is required.
What Does Curafluke 5% Treat?
- Liver Fluke: Treats mature and immature Fasciola hepatica over eight weeks old.
- Gastrointestinal Roundworms: Treats susceptible mature and immature stages of stomach and intestinal worms, including Haemonchus, Ostertagia, Trichostrongylus, Cooperia and Nematodirus species.
- Lungworms: Treats susceptible Dictyocaulus species.
- Tapeworms: Treats susceptible Moniezia species.
- Type II Ostertagiasis: The supplied SPC reports a good therapeutic effect against Type II Ostertagiasis.
Refer to the product datasheet for the complete list of susceptible parasites and stages.
Key Features of Curafluke 5%
- For Cattle and Sheep: Suitable for both species when administered at the correct species-specific dosage.
- Three-Way Parasite Control: Targets liver fluke, gastrointestinal worms and lungworms.
- Two Active Ingredients: Combines fenbendazole and rafoxanide in one oral drench.
- Immature and Mature Liver Fluke: Treats fluke over eight weeks old, as well as mature fluke.
- Convenient Oral Administration: A practical drenching option for livestock.
- Broad-Spectrum Worming: Treats a range of susceptible roundworms and tapeworms.
- Supports Livestock Health: Appropriate parasite control can help reduce the effects of worm and fluke burdens on animal health and performance.
Understanding Liver Fluke in Cattle and Sheep
Liver fluke is an important parasite affecting cattle and sheep in Ireland, particularly on farms with wet or poorly drained grazing land.
Livestock become infected when they ingest infective liver fluke larvae, known as metacercariae, while grazing contaminated pasture.
Wet Ground Increases Fluke Risk
Wet and poorly drained areas can provide suitable conditions for the mud snails involved in the liver fluke lifecycle. These areas may increase the risk of livestock being exposed to infective fluke larvae.
When Is Liver Fluke Most Common?
Fluke risk can increase from late summer through winter, depending on rainfall, temperature and local grazing conditions.
Although some farms have known fluke-prone fields, infection risk should not be ruled out elsewhere. Cattle and sheep may encounter contaminated pasture even where liver fluke has not previously been identified as a major problem.
Why Is Fluke Control Important?
- Animal Health: Liver fluke infection can affect liver function and overall condition.
- Growth and Performance: Parasite burdens can reduce feed efficiency and liveweight gain.
- Housing Management: Assessing fluke risk around housing can help farmers plan appropriate treatment.
- Grazing Management: Identifying wet or fluke-prone fields can help reduce exposure.
Curafluke 5% provides treatment against susceptible liver fluke stages over eight weeks old, alongside its activity against gastrointestinal worms and lungworms.
Note: Treatment choice should take account of the age of the fluke infection, farm history and veterinary advice. Curafluke should not be relied upon to treat liver fluke younger than eight weeks.
Administration and Precautions
- Oral Administration Only: Administer by mouth using suitable drenching equipment.
- Shake Well Before Use: Ensure the suspension is properly mixed before administering.
- Cattle Dosage: 11.25 ml per 50 kg bodyweight.
- Sheep Dosage: 1.5 ml per 10 kg bodyweight.
- Estimate bodyweight as accurately as possible before treatment.
- Use properly calibrated dosing equipment.
- Take care when inserting the dosing gun to avoid injury to the animal's mouth or throat.
- Avoid frequent or repeated use of anthelmintics from the same class without an appropriate parasite-control plan.
- Do not use in animals producing milk for human consumption, including during the dry period.
- Observe the 60-day cattle and 54-day sheep meat withdrawal periods.
- Seek veterinary advice if treatment does not achieve the expected result, as parasite resistance or other health problems may be involved.
Storage and Shelf Life
- Shelf Life: 3 years unopened in white HDPE containers.
- Storage Temperature: Store below 25°C.
- Light Protection: Protect from light.
- Frost Protection: Protect from frost.
- Product Form: Pale lemon oral suspension.
- Pack Sizes: 1 Litre, 2.5 Litre and 5 Litre.
- Marketing Authorisation Holder: Univet Limited, Tullyvin, Cootehill, Co. Cavan, Ireland.
- Irish Marketing Authorisation: VPA10990/032/001.
Important: Always read the current product label and datasheet before administering Curafluke 5% Oral Drench. Follow the correct species-specific dosage and observe all withdrawal periods and milk-use restrictions.
Click here to Download Data Sheet
Health Products Regulatory Authority
Summary of Product Characteristics
1 NAME OF THE VETERINARY MEDICINAL PRODUCT
Curafluke 5% w/v Oral Drench
2 QUALITATIVE AND QUANTITATIVE COMPOSITION
Each 1 ml of suspension contains:
Active Substance
Fenbendazole 50.00 mg
Rafoxanide 50.00 mg
Excipients
Propyl parahydroxybenzoate 0.10 mg
Methyl parahydroxybenzoate 1.00 mg
Quinoline yellow (E104) 0.09 mg
For a full list of excipients, see section
6.1. 3 PHARMACEUTICAL FORM
Oral Suspension.
A pale, lemon suspension.
4 CLINICAL PARTICULARS
4.1 Target Species
Cattle and sheep.
4.2 Indications for use, specifying the target species
Curafluke 5% Oral Drench permits a three way activity against Fluke, Lungworms and Stomach Worms in Cattle and Sheep.
It is a broad spectrum anthelmintic for the treatment of benzimidazole susceptible mature and immature stages of nematodes and cestodes of the gastrointestinal and respiratory tracts of cattle and sheep.
Rafoxanide is active against immature and mature Fasciola hepatica (mature and immature over 8 weeks of age).
Cattle and Sheep:
Haemonchus sp.
Ostertagia sp.
Trichostrongylus sp.
Cooperia sp.
Nematodirus sp.
Bunostomum sp.
Trichuris sp.
Strongyloides sp.
Oesophagostomum sp.
Dictyocaulus sp.
Moniezia sp.
Fasciola hepatica (mature and immature over 8 weeks of age).
The product has a good therapeutic effect against type II Ostertagiasis.
4.3 Contraindications
None.
4.4 Special warnings for each target species
Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy.
Too frequent and repeated use of anthelmintics from the same class over an extended period of time.
Underdosing, which may be due to under-estimation of the bodyweight, mis-administration of the product or lack of calibration of the dosing device (if any).
As with other anthelmintics, veterinary advice should be sought on appropriate dosing programmes and stock management to achieve adequate parasite control and reduce the likelihood on anthelmintics resistance developing. If the product does not achieve the desired clinical effect, other diseases, nutritional diseases or anthelmintic resistance may be involved.
4.5 Special precautions for use
Special precautions for use in animals
Where a dosing gun is used to administer the product care must be taken to avoid the occurrence of dosing gun pharyngitis.
Special precautions to be taken by the person administering the veterinary medicinal product to animals Wash hands after use.
4.6 Adverse reactions (frequency and seriousness)
None known.
4.7 Use during pregnancy, lactation or lay
Fenbendazole and rafoxanide are safe for use during pregnancy. See section 4.11
4.8 Interaction with other medicinal products and other forms of interactions
None known.
4.9 Amounts to be administered and administration route
For oral administration in cattle and sheep.
For sheep, the recommended therapeutic dose is 7.5 mg fenbendazole and
7.5 mg rafoxanide per kilogram bodyweight.
For cattle, the recommended therapeutic dose is 11.25 mg fenbendazole and
11.25 mg rafoxanide per kilogram bodyweight.
Shake well before use
Estimate bodyweight carefully.
Use only properly calibrated dosing equipment.
Practical dosage recommendations are as follows:
Bodyweight (Kg) Dose (ml)
CATTLE
50 11.25
100 22.5
400 90.0
> 400 kg 11.25 ml/50 kg
SHEEP
10 1.5
50 7.5
At 2 months after housing, when dosing cattle for worms and adult fluke, a lower dose of 7.5 mg/kg can be used i.e. 7.5 ml per 50kg bodyweight,
30 ml per 200 kg or
75 ml per 500 kg.
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
Curafluke 5% Oral Drench is well tolerated in cattle at three times the recommended dosage
4.11 Withdrawal period(s)
Meat: Cattle - 60 days.
Animals intended for human consumption may be slaughtered only from 60 days after the last treatment.
Sheep - 54 days.
Animals intended for human consumption may be slaughtered only from 54 days after the last treatment.
Milk: Not authorised for use in animals producing milk for human consumption including during the dry period.
Do not use during the last trimester of pregnancy in heifers which are intended to produce milk for human consumption.
Do not use within 1 year prior to the first lambing in ewes intended to produce milk for human consumption.
5 PHARMACOLOGICAL or IMMUNOLOGICAL PROPERTIES
ATC Vet Code:
QP52AC30
Pharmacotherapeutic Group:
Anthelmintics,
combinations of benzimadazoles and related substances.
Curafluke 5% Oral Drench is a broad spectrum anthelmintic.
6 PHARMACEUTICAL PARTICULARS
6.1 List of excipients
Xanthan gum (E415)
Quinoline yellow (E104)
Simethicone emulsion
Propyl parahydroxybenzoate (E216)
Methyl parahydroxybenzoate (E218)
Polysorbate 80 Sodium citrate (E331)
Sodium metabisulphite (E223)
Citric acid monohydrate
Purified water
6.2 Major incompatibilities
None known.
6.3 Shelf-life
Shelf-life of the veterinary medicinal product as packaged for sale:
White HDPE containers: Three years
6.4 Special precautions for storage
Store below 25°C.
Protect from light and frost.
6.5 Nature and composition of immediate packaging
1L (jerrican, backpack),
2.5L (jerrican, backpack) or
5L (jerrican, backpack)
HDPE white containers with a HDPP screw cap and a wood pulp PVDC liner.
The product may be marketed with or without an outer carton.
Not all pack sizes may be marketed
6.6 Special precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products
Unused product or waste material should be disposed of in accordance with current practice for pharmaceutical waste under national waste disposal regulations
7 MARKETING AUTHORISATION HOLDER
Univet Limited
Tullyvin
Cootehill
Co. Cavan.
Ireland
8 MARKETING AUTHORISATION NUMBER(S)
VPA10990/032/001
9 DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION
Date of first authorisation: 05 September 1997
Date of last renewal: 04 September 2007
10 DATE OF REVISION OF THE TEXT
January 2018
Drench correctly
Sheep Oral Drench
The drenching technique is a vital part of ensuring that the wormer does its job effectively.
Make sure the sheep are properly restrained and cannot leap around when they are being drenched so they swallow the whole amount.
Sheep can also suffer serious injury, or even death, if they are unrestrained and the gun penetrates the tissues at the back of the mouth.
Place a hand under the head and tilt slightly to the side.
Slot the nozzle in the gap between molar and incisor teeth and then over the back of the tongue.
If the wormer is just put into the mouth, it will bypass the rumen as it escapes down the oesophageal groove and will be less effective.
This is particularly important for white (BZ) drenches.
Dosing Weigh – do not guess Underestimating the weight of sheep is a common cause of underdosing. Select and weigh the biggest sheep in the group to determine the correct dose. If there is a wide range of weights, consider splitting the group, then weigh the heaviest in each section. Do not forget to check that the weigh crate is accurate before starting!
Calibrate and maintain the drench gun
Always check the gun is delivering the right amount before you drench. Remove the plunger from a 10 ml syringe, put a thumb over the end and squirt the dose into it, making sure there are no air bubbles left. Adjust the gun until the dose delivered is correct. Drenching guns should also be well maintained and replaced regularly. Clean with warm soapy water after use and check springs and tubes to make sure there are no kinks that will form air bubbles.
Withholding food
Research has shown that the efficacy of the white (BZ) and clear (AV) drenches can be improved by withholding food for 12–24 hours before treatment. It is not advised to deprive heavily pregnant ewes of food, so if you treat this class of stock with anthelmintics, you may wish to use yellow drenches (LV) because their efficacy is less dependent on rumen fill.
Storage
Wormers should be stored securely, away from direct sunlight at 4–25°C. Check the use-by date and, once open, use within the time shown on the packaging. Shake white (BZ) products well before use.
Cattle Oral drenches
Oral drenching guns are designed to deliver the treatment towards the back of the mouth over the tongue, so the entire dose is swallowed at once to optimise efficacy.
• Make sure animals are properly restrained, with their head held up
• Slide the nozzle of the dosing gun in the side of the mouth and over the tongue so that the entire dose is swallowed immediately
• Drenching equipment must be correctly calibrated and in good working order
• Calibrate the gun using the product just before treatment starts by delivering two or more doses into a graduated measuring cylinder.
Faulty equipment, or attempting to dose too quickly, may mean that the barrel of the gun does not fill properly or that the liquid is full of bubbles.
Curafluke 5% oral solution is a broad spectrum flukicide and wormer for sheep and cattle. Curafluke 5% is used for the treatment and control of stomach worms, lungworms, mature and immature fluke, in sheep and beef cattle.
Active Ingredient: Rafoxanide, Fenbendazole
Target Species: Cattle, sheep
Treats and Controls: Stomach worms, lungworms, mature and immature fluke
Withdrawal Time: 60 days for cattle intended for meat and offal, not permitted for use on cattle producing milk for human consumption. 54 days for sheep intended for meat and offal, not permitted for use on sheep producing milk for human consumption
Legal Status: POM
Delivery Information
- Fast Nationwide Delivery (Ireland)
- Standard Delivery - orders under €129 are €6.99
- Free Shipping for orders over €129
- Typically 2-4 days for delivery
Note: Some products may have an extra heavy/bulk delivery charge; this will be noted on the product page.
Delivery Service
Here at Agridirect we have joined forces with An Post & DPD to ensure all packages are delivered promptly and safely to you. We ship to all mainland countries within the EU. Deliveries take place Monday to Friday, excluding bank holidays. Once your order has been dispatched from our warehouse, you will be notified by email. If there is a delay with your order for any reason, you will be contacted immediately.
Delivery Times
- Ireland (ROI & NI) - 2-4 Working Days
- EU (Mainland Only) - 4-6 Working Days
Some products have an extended delivery time, this is noted on the products.
Delivery Rates
- Country - Delivery Charge
- Ireland (ROI & NI) - €6.99
- Austria - €39.99
- Belgium - €36.99
- Czech Republic - €39.99
- Denmark - €39.99
- Finland - €51.99
- France - €36.99
- Germany - €36.99
- Hungary - €43.99
- Italy - €49.99
- Luxembourg - €36.99
- Netherlands - €36.99
- Poland - €36.99
- Portugal - €51.99
- Slovakia - €43.99
- Slovenia - €43.99
- Spain - €49.99
- Sweden - €49.99
A selection of the products we sell are only licensed for sale within the Republic Of Ireland and can not be shipped outside of the country. These products are noted as only being available within the Republic of Ireland on the individual product pages.
Note: There may be an additional charge on certain bulky items. This charge will be clearly marked on applicable products and will be explained on the checkout page before payment has been made.
Returns Policy
We’re sorry your purchase didn’t work out. But don’t worry; we have a great returns policy to help you out.
All purchases can be returned to us within 14 days of delivery, and returned goods must be received within 14 days from the date you informed us of the return.
Purchases may be opened for inspection but must not be used and must be repackaged securely in the original packaging if you wish to return it.
If we discover goods have been used or there has been a loss in value of the goods due to damage to the goods while in your care or whilst being returned to us, we will reduce the amount refunded, which may amount to the full cost of the product, to cover the loss of value of the goods.
All returns should be complete, which includes boxes, manuals, and accessories that may have been included with the order.
All returns must be packaged appropriately for shipping; we will not accept responsibility for damages or loss that occurs during shipping of a return product.
We accept no responsibility for goods damaged or lost while in transit to us.
How do I return a product?
We have partnered with DPD to make your returns process easy and secure. Simply follow the steps below and bring your package to an official DPD pickup point.
1) All returns must be accompanied with a fully filled out returns form which can be downloaded returns form PDF.
2) To print off your return label click DPD Returns page or visit www.dpd.ie/returns and follow the on-screen instructions. Make sure and use your order number as your reference.
- Select “Continue as Guest”
- Select “Agridirect” from the drop-down menu
- Select your reason for returning
- Select the size of the package you wish to return
- Accept DPD’s terms and conditions
- Fill in your payment details
- Fill in your own details
- Follow the instructions to print off your label
3) Bring your package to a DPD pickup point. To find your nearest drop off point DPD pickup shops.
Once the returned product has been received into our warehouse and been fully inspected a refund will be issued.
If you choose not to use the DPD returns service we recommend that you use a method that can be tracked.
For the return of bulk products please contact us at sales@agridirect.ie
I have received a damaged product from you, what should I do?
First off, if you have received a damaged electrical product from us, do not plug it in. Any electrical products that are plugged in are deemed ‘as used and accepted’ and are not accepted as returns. All damages must be reported to us via phone or email within 24hours of receipt of goods. Please ensure you check your items upon delivery.
How do I begin the returns process?
If you wish to begin the return process, please email us at sales@agridirect.ie and ensure the following information is included in your email. Your name, phone number, Order id, the item you wish to return, reason for return and if the product is damaged we require photos of the product.
Once you have sent us all required information a member of our team will assess your claim and will contact you as soon as possible. Please hold off on returning products until a member of our team has called you to confirm.
Refunds
Once the returned product has been returned to us and fully inspected a refund will be issued.
Please Note: A typical timeline for a refund to show in your account is up to 10 working days from the date processed, depending on your bank.