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Bovicox (Toltrazuril)
Bovicox (Toltrazuril)

Bovicox (Toltrazuril)

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Bovicox 50 mg/ml oral suspension for cattle  and sheep and is used in the treatment and prevention of coccidiosis (caused by Eimeria bovis or Eimeria zuernii) in calves,cattle and sheep. Bovicox is a highly reliable market replacement for Vecoxan . Coccidiosis is a very costly disease that causes severe sickness and even death in cattle, Bovicox not only treats this disease but can also prevent your herd from contracting it in the first place.
 
 
 

What is coccidiosis?

 
Coccidiosis is a highly contagious disease that normally infects calves between one and six months of age but can also infect older cattle as well. Coccidiosis is caused by a single celled microscopic parasite that multiplies in the intestine of infected animals, the eggs are then passed through faeces onto the soil and grass where they are eaten by other animals which then become infected. Coccidiosisis still one of the most common and costly diseases a farmer can face on his farm.
 
 
 

What are the symptoms of Coccidiosis?

 
Common symptoms of Coccidiosis are diarrhoea, rough coat, loss of appetite, loss of weight and weakness in calves. In severe cases there will be blood and mucus present in the animals manure and if left untreated will lead to the animal's death.
 
 
 
 

How Bovicox works

 
The active ingredient in Bovicox is Toltrazuril. Toltrazuril kills all stages of  Coccidiosis (including schizonts, microgamonts and macrogamonts). In calves Bovicox kills all developing stages of Coccidiosis while still allowing the calf to develop a natural immunity to the disease.
 

Active Ingredients
Toltrazuril
 

Target Species
Cattle and Sheep
 

Application Method
For oral use.
 

Withdrawal Period
Cattle: Meat and offal: 63 days.
Not authorised for use in animals producing milk for human consumption.
Sheep: Meat and offal: 42 days.
Not authorised for use in animals producing milk for human consumption.

 

Dosage
Cattle:
Each animal: a single oral dose of 15 mg toltrazuril/kg body weight (i.e. 3.0 ml of the product/10 kg bw.).
For the treatment of a group of animals of the same breed and same or similar age, the dosing should be done according to the heaviest animal of this group.
Sheep:
Each animal: a single oral dose of 20 mg toltrazuril/kg body weight (i.e. 0.4 ml of the product/kg bw.).
If animals are to be treated collectively rather than individually, they should be grouped according to their body weight and dosed accordingly, in order to avoid under- or over-dosing.
The ready-to-use oral suspension must be shaken before use.

To ensure administration of a correct dose, body weight should be determined as accurately as possible.
To obtain maximum benefit, animals should be treated before the expected onset of clinical signs, i.e. in the prepatent period.
Treatment during an outbreak will be of limited value for the individual animal, because of damage to the small intestine having already occurred.

 

 

Key Features of Bovicox

 
  • Single dose oral administration
  • Long lasting
  • Use as a prevention or a cure
  • Allows the animal to build a natural immunity to the disease
  • Safe and easy to use

This Product is only licensed for sale in the Republic of Ireland

Bovicox is an oral suspension that should be administered at a dosage rate of  3 ml per 10kg bodyweight for calves and at a dosage rate of 4ml per 10kg bodyweight.
 
To ensure administration of a correct dose of Bovicox, body weight should be determined as accurately as possible; accuracy of the dosing device should be checked. If animals are to be treated collectively rather than individually, they should be grouped according to their bodyweight and dosed accordingly, in order to avoid under or overdosing.

 

Dosage rates for calves
Body WeightDose VolumeNumber of full doses per pack:
250ml1 Litre
100kg30 ml833
120kg36 ml627
140kg42 ml623
160kg48 ml520
180kg54 ml418
200kg60 ml416
220kg66 ml315
240kg72 ml313
260kg78 ml312
280kg84 ml211
300kg90 ml211

 

Dosage rates for sheep
Body WeightDose VolumeNumber of full doses per pack:
250 ml1 Litre
10kg4 ml62250
20kg8 ml31125
30kg12 ml2083
40kg16 ml1562
50kg20 ml1250
60kg24 ml1041
70kg28 ml835

 

 
 
 
 
Precautions
 
Cattle must not be treated within 63 days of slaughter for human consumption. Not permitted for use in animals producing milk for human consumption, including pregnant animals intended to produce milk for human consumption

Click here to Download Data Sheet

Health Products Regulatory Authority

 Summary of Product Characteristics

1 NAME OF THE VETERINARY MEDICINAL PRODUCT
Bovicox 50 mg/ml oral suspension for cattle and sheep

2 QUALITATIVE AND QUANTITATIVE COMPOSITION
1 ml of oral suspension contains:
Active substance:
Toltrazuril 50 mg
Excipients:
Sodium benzoate (E211) 2.1 mg
Sodium propionate (E281) 2.1 mg
For the full list of excipients, see section 6.1

3 PHARMACEUTICAL FORM
Oral suspension.
Thick white suspension.

4 CLINICAL PARTICULARS
4.1 Target Species

Cattle (calves on dairy farms).
Sheep (lambs).

4.2 Indications for use, specifying the target species
Cattle:
For the prevention of clinical signs of coccidiosis and reduction of oocyst shedding in housed calves replacing cows producing milk for human consumption (dairy cows) on farms with a confirmed history of coccidiosis caused by Eimeria bovis or Eimeria zuernii.

Sheep:
For the prevention of clinical signs of coccidiosis and reduction of oocyst shedding in lambs on farms with a confirmed history of coccidiosis caused by Eimeria crandallis and Eimeria ovinoidalis.

4.3 Contraindications
Do not use in cases of hypersensitivity to the active substance or to any of the excipients.
Cattle: For environmental reasons:
Do not use in calves weighing more than 80 kg body weight.
Do not use in fattening units such as veal or beef calves.
For more details see sections 4.5, other precautions and section 5, environmental properties.

4.4 Special warnings for each target species
As with any antiparasiticide frequent and repeated use of antiprotozoals from the same class may lead to the development of resistance.
It is recommended to treat all calves or lambs in a pen. 
Hygienic measures may reduce the risk of coccidiosis.
It is therefore, recommended to improve concomitantly the hygienic conditions in the concerned facility, particularly dryness and cleanliness.
To obtain maximum benefit, animals should be treated before the expected onset of clinical signs, i.e. in the prepatent period.
To alter the course of an established clinical coccidial infection, in individual animals already showing signs of diarrhoea, additional supportive therapy may be required.

4.5 Special precautions for use
Special precautions for use in animals

None.

Special precautions to be taken by the person administering the veterinary medicinal product to animals
People with known hypersensitivity to any of the ingredients should avoid contact with the veterinary medicinal product. Wash any splashes from skin or eyes immediately with water.

Other precautions
The major metabolite of toltrazuril, toltrazuril sulfone (ponazuril), has been shown to be both persistent (half-life > 1 year) and mobile in soil and to be toxic to plants.
In order to prevent any adverse effects on plants and possible contamination of groundwater, manure from treated calves must be not be spread onto land without dilution with manure from untreated cows.
Manure from treated calves must be diluted with at least 3 times the weight of manure from mature cows before it can be spread onto land.
Lambs kept throughout the whole life span indoors under an intensive rearing system must not be treated beyond the age of 6 weeks or body weight of more than 20 kg at treatment.
Manure from these animals should only be applied to the same piece of land every third year.

4.6 Adverse reactions (frequency and seriousness)
None known.

4.7 Use during pregnancy, lactation or lay
Not applicable.

4.8 Interaction with other medicinal products and other forms of interactions
None known.

4.9 Amounts to be administered and administration route
For oral use.
Cattle:
Each animal: a single oral dose of 15 mg toltrazuril/kg body weight (i.e. 3.0 ml of the product/10 kg bw.).
For the treatment of a group of animals of the same breed and same or similar age, the dosing should be done according to the heaviest animal of this group.

Sheep:
Each animal: a single oral dose of 20 mg toltrazuril/kg body weight (i.e. 0.4 ml of the product/kg bw.).
If animals are to be treated collectively rather than individually, they should be grouped according to their body weight and dosed accordingly, in order to avoid under- or over-dosing.
The ready-to-use oral suspension must be shaken before use.

To ensure administration of a correct dose, body weight should be determined as accurately as possible.
To obtain maximum benefit, animals should be treated before the expected onset of clinical signs, i.e. in the prepatent period.
Treatment during an outbreak will be of limited value for the individual animal, because of damage to the small intestine having already occurred. 

4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
A threefold overdose is well tolerated by calves without signs of intolerance.
In lambs, no signs of overdose have been observed with threefold overdose at a single treatment and twofold overdose at treatment on two consecutive days.

4.11 Withdrawal period(s)
Cattle: Meat and offal: 63 days.
Not authorised for use in animals producing milk for human consumption.

Sheep:Meat and offal:42 days.
Not authorised for use in animals producing milk for human consumption.

5 PHARMACOLOGICAL or IMMUNOLOGICAL PROPERTIES
Pharmacotherapeutic group:

Antiprotozoals, triazines, toltrazuril.


ATCvet code:
QP51AJ01

5.1 Pharmacodynamic properties
Toltrazuril is a triazinon derivative. It acts against coccidia of the genus Eimeria.
It is active against all intracellular development stages of coccidia of the merogony (asexual multiplication) and gamogony (sexual phase).
All stages are destroyed, and hence the mode of action is coccidiocidal.

5.2 Pharmacokinetic particulars
Cattle:
After oral administration of the product in cattle, toltrazuril is slowly absorbed.
The maximal plasma concentration (Cmax = 41.4 mg/l) was observed between 6.00 and 48 hours (median 18 hours) following oral administration.
The elimination of toltrazuril is slow with a terminal half-life time of approximately 2.5 days (59.5 hours).
The main metabolite is characterised as toltrazuril sulfone.
The major route of excretion is via the faeces.

Sheep:
After oral administration of the product in sheep, toltrazuril is slowly absorbed.
The main metabolite is characterised as toltrazuril sulfone.
The maximal plasma concentration (Cmax = 64.6 mg/L) was observed between 12 and 120 hours (median 18 hours) following a single oral dose of 20 mg/kg bw.
The elimination of toltrazuril is slow with an elimination half-life time of up to 9 days (mean 5 days).
The major route of excretion is via the faeces.

5.3 Environmental properties
The metabolite of toltrazuril, toltrazuril sulfone (ponazuril) is a persistent (half-life >1 year) and mobile compound and has adverse effects on both the growth and emergence of plants.

Given the persistent properties of ponazuril, repeated spreading of manure from treated animals may lead to an accumulation in the soil and consequently a risk to plants.
The accumulation of ponazuril in soil together with its mobility also leads to a risk of leaching to groundwater.
See sections 4.3 and 4.5.

6 PHARMACEUTICAL PARTICULARS
6.1 List of excipients

Sodium benzoate (E211)
Sodium propionate (E281)
Propylene glycol
Docusate sodium
Simeticone emulsion
Aluminium magnesium silicate
Citric acid monohydrate 
Xanthan gum
Water, purified

6.2 Major incompatibilities
In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.

6.3 Shelf-life
Shelf-life of the veterinary medicinal product as packaged for sale: 3 years.
Shelf-life after first opening the immediate packaging: 1 year.

6.4 Special precautions for storage This veterinary medicinal product does not require any special storage conditions

6.5 Nature and composition of immediate packaging.  
Bottle (HDPE), closure (HDPE), sealing liner (LDPE):                250 ml of oral suspension in a box.
Bottle (HDPE), closure (HDPE), sealing liner (LDPE):              1000 ml of oral suspension in a box.
Not all pack sizes may be marketed.

6.6 Special precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

7 MARKETING AUTHORISATION HOLDER
J. & M. Veterinary Services Ltd
30 Coolmine Business Park,
Clonsilla Road,
Dublin 15
Ireland

8 MARKETING AUTHORISATION NUMBER(S)
VPA10954/011/001

9 DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION
Date of first authorisation: 20th September 2013
Date of last renewal: 19th September 2018

10 DATE OF REVISION OF THE TEXT
September 2019

Drench correctly
Sheep Oral Drench

The drenching technique is a vital part of ensuring that the wormer does its job effectively.
Make sure the sheep are properly restrained and cannot leap around when they are being drenched so they swallow the whole amount.
Sheep can also suffer serious injury, or even death, if they are unrestrained and the gun penetrates the tissues at the back of the mouth.
Place a hand under the head and tilt slightly to the side.
Slot the nozzle in the gap between molar and incisor teeth and then over the back of the tongue.
If the wormer is just put into the mouth, it will bypass the rumen as it escapes down the oesophageal groove and will be less effective.
This is particularly important for white (BZ) drenches.

Dosing Weigh – do not guess Underestimating the weight of sheep is a common cause of underdosing. Select and weigh the biggest sheep in the group to determine the correct dose. If there is a wide range of weights, consider splitting the group, then weigh the heaviest in each section. Do not forget to check that the weigh crate is accurate before starting!

Calibrate and maintain the drench gun
Always check the gun is delivering the right amount before you drench. Remove the plunger from a 10 ml syringe, put a thumb over the end and squirt the dose into it, making sure there are no air bubbles left. Adjust the gun until the dose delivered is correct. Drenching guns should also be well maintained and replaced regularly. Clean with warm soapy water after use and check springs and tubes to make sure there are no kinks that will form air bubbles.

Withholding food
Research has shown that the efficacy of the white (BZ) and clear (AV) drenches can be improved by withholding food for 12–24 hours before treatment. It is not advised to deprive heavily pregnant ewes of food, so if you treat this class of stock with anthelmintics, you may wish to use yellow drenches (LV) because their efficacy is less dependent on rumen fill.

Storage
Wormers should be stored securely, away from direct sunlight at 4–25°C. Check the use-by date and, once open, use within the time shown on the packaging. Shake white (BZ) products well before use.

 Cattle Oral drenches
Oral drenching guns are designed to deliver the treatment towards the back of the mouth over the tongue, so the entire dose is swallowed at once to optimise efficacy.
• Make sure animals are properly restrained, with their head held up
• Slide the nozzle of the dosing gun in the side of the mouth and over the tongue so that the entire dose is swallowed immediately
• Drenching equipment must be correctly calibrated and in good working order
• Calibrate the gun using the product just before treatment starts by delivering two or more doses into a graduated measuring cylinder. 
Faulty equipment, or attempting to dose too quickly, may mean that the barrel of the gun does not fill properly or that the liquid is full of bubbles.

Delivery Information

Delivery Service

Here at Agridirect we have joined forces with DPD to ensure all packages are delivered promptly and safely to you. We ship to all mainland countries within the EU. Deliveries take place Monday to Friday excluding bank holidays. Once your order has been dispatched from our warehouse you will be notified by email. If there is a delay with your order for any reason you will be contacted immediately. 

Due to Brexit we are temporarily unable to ship to the UK. Shipping to Northern Ireland will remain in place.

Delivery Times
Ireland (ROI & NI)EU (Mainland Only)
2-4 Working Days4-6 Working Days

Some product have an extended delivery time, this is noted on the products.

Delivery Rates

CountryOrders Under €99Orders Over €99
Ireland (ROI & NI)€6.99€0.00
Austria€19.99€13.00
Belgium€16.99€10.00
Czech Republic€19.99€13.00
Denmark€19.99€13.00
Finland€31.99€25.00
France€16.99€10.00
Germany€16.99€10.00
Hungary€23.99€17.00
Italy€29.99€23.00
Luxenburg€16.99€10.00
Netherlands€16.99€10.00
Poland€16.99€13.00
Portugal€31.99€25.00
Slovakia€23.99€17.00
Slovenia€23.99€17.00
Spain€29.99€23.00
Sweden€29.99€23.00

 

A selection of the products we sell are only licensed for sale within the Republic Of Ireland and can not be shipped outside of the country. These products are noted as only being available within the Republic of Ireland on the individual product pages.

There may be an addition charge on certain bulky items. This charge will be clearly marked on an applicable products and will be explained on the checkout page before payment has been made.

Agridirect Returns Policy

We’re sorry your purchase didn’t work out. But don’t worry; we have a great returns policy to help you out, plus returns are free.

All purchases can be returned to us within 14 days of delivery and returned goods must be received within 14 days from the date you informed us of the return.

Purchases may be opened for inspection but must not be used and must be repackaged securely in the original packaging if you wish to return it.
 

If we discover goods have been used or there has been a loss in value of the goods due to damage to the goods, while in your care or whilst being returned to us, we will reduce the amount refunded, which may amount to the full cost of the product, to cover loss of value of goods.

All returns should be complete which includes boxes, manuals and accessories that may have been included with the order.

All returns must be packaged appropriately for shipping, we will not accept responsibility for damages or loss which occur during shipping of a return product.

We accept no responsibility for goods damaged or lost while in transit to us. 

How do I return a product?

Making returns to us are free, simply follow the steps below and bring your package to an official DPD pickup point.

  • All returns must be accompanied with a fully filled out returns form which can be downloaded here.
  • To print off your return label click here or visit www.dpd.ie/returns and follow the on-screen instructions. Make sure and use your order number as your reference.
  • Bring your package to a DPD pickup point. To find your nearest drop off point here.

Once the returned product has been received into our warehouse and been fully inspected a refund will be issued.

For the return of bulk products please contact us at sales@agridirect.ie

I have received a damaged product from you, what should I do?

First off, if you have received a damaged electrical product from us, do not plug it in. Any electrical products that are plugged in are deemed ‘as used and accepted’ and are not accepted as returns. All damages must be reported to us via phone or email within 24hours of receipt of goods. Please ensure you check your items upon delivery.

How do I begin the returns process?

If you wish to begin the return process, please email us at sales@agridirect.ie and ensure the following information is included in your email. Your name, phone number, Order id, the item you wish to return, reason for return and if the product is damaged we require photos of the product.

Once you have sent us all required information a member of our team will assess your claim and will contact you as soon as possible. Please hold off on returning products until a member of our team has called you to confirm.

Refunds

Once the returned product has been returned to us and fully inspected a refund will be issued.

Please Note: A typical timeline for a refund to show in your account is up to 10 working days from the date processed, depending on your bank.

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