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Zanil - 5 Litre (Oxyclozanide)
Zanil - 5 Litre (Oxyclozanide)
Zanil - 5 Litre (Oxyclozanide)

Zanil - 5 Litre (Oxyclozanide)

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This product is only licensed for sale in the Republic Of Ireland

Zanil fluke drench is an orally adminstered drench for the treatment and control of liver and Tapeworms in cattle and sheep. Zanil's active ingredient, Oxyclozanide, has shown to have a  high impact on rumen fluke that are present in the bile duct of the animal. Zanil is appropriate for use on both sheep and cattle all year round, although in housed animals the treatment should be re-administered 8 to 12 weeks later to control the threat of immature fluke that may have been present at the time of housing. Zanil also boast a very short withdrawal time for dairy cattle.

Active Ingredient: Oxyclozanide

Target Species: Cattle, sheep

Administration Method: Oral drench

Treats and Controls: Liver fluke, tapeworm

Withdrawal Time: 13 days for cattle intended for meat and offal, 108 hours for cattle producing milk for human consumption. 14 days for sheep intended for meat and offal, 7 days for sheep producing milk for human consumption

Dosage for cattle: 15 ml per 50 kg of bodyweight

Body WeightDose VolumeNumber of full doses per pack
5 Litre
50kg15 ml333
100kg30 ml167
150kg45 ml111
200kg60 ml83
250kg90 ml56
350kg and over105 ml48


Dosage for sheep:4.5ml per 10kg Bodyweight

Body WeightDose VolumeNumber of full doses per pack
5 Litre
10kg4.5 ml1111
20kg9 ml556
30kg13.5 ml370
40kg18 ml278
50kg22.5 ml222
60kg27 ml185
70kg31.5 ml159

Always read the label and all enclosed information for Zanil Oral Suspension before administering to animals!

Key Features of Zanil:

  • An orally adminstered drench
  • Helps with the treatment and control of liver and Tapeworms
  • Used in cattle and sheep. 
  • Oxyclozanide has a high impact on rumen fluke 
  • Can be used all year round.
  •  A very short withdrawal time for dairy cattle.

According to "Liver Fluke - the Facts", a paper published by Animal Health Ireland (AHI), liver fluke costs the worldwide livestock and food industries an estimated €2.5 million per year. These financial losses associated with liver fluke are mainly due to a reduction in the amount of milk and meat produced. Liver fluke can cause a loss of up to 20% in cattle, 30% in sheep and a loss of up to 8% in the milk production of dairy cows.

Identifying infected cattle:

It can sometimes be hard to see the signs of fluke in infected cattle and a slight decline in the performance of the herd can be hard to associate to a single factor. Yet liver fluke affects at least 50% of all Irish herds. The following lists will show some of the common signs that your herd has been infected by liver fluke.

In Young Stock

  • Weakened calves
  • Reduced weight at the time of weaning caused by both the poor quality and quantity of the milk being produced
  • Poor feed conversion
  • On occasion anaemia, loss of weight and even death in animals younger than 2 years old.

In Breeding Stock

  • Weakened or incapacitated cows, especially in later stages of pregnancy.
  • Lower fertility rates which leads to an increase in culls
  • Sale weight of cull cows reduced
  • Production of milk is greatly reduced
  • Reduction in the nutritional value of the milk
  • Lower conception rates
  • Slower growth in heifers
  • Delay in the onset of first oestrus in the herd
  • Poor reproductive performance from bulls

​This product is only licensed for sale within the Republic of Ireland

Click here to Download Data Sheet

Summary of Product Characteristics

1 NAME OF THE VETERINARY MEDICINAL PRODUCT
Zanil Fluke Drench

2 QUALITATIVE AND QUANTITATIVE COMPOSITION

Active Substance
Oxyclozanide 3.4 % w/v

Excipients
Methyl Parahydroxybenzoate E218 0.15 % w/v
Propyl Parahydroxybenzoate E216 0.015 % w/v
Sodium Metabisulphite E223
Sodium Citrate E331

3 PHARMACEUTICAL FORM
Oral suspension.
A smooth off-white suspension.

4 CLINICAL PARTICULARS

4.1 Target Species
Cattle and Sheep.

4.2 Indications for use, specifying the target species
Indications: For the treatment and control of fascioliasis in cattle and sheep.
It removes practically all adult flukes (Fasciola spp.) present in the bile ducts of the liver. Tapeworm segments
(Moniezia) are also removed.

4.3 Contraindications
Do not use in sheep producing milk for human consumption.
Do not use in animals with known hypersensitivity to the active ingredient.
Active Substance
Oxyclozanide 3.4 % w/v
Excipients
Methyl Parahydroxybenzoate E218 0.15 % w/v
Propyl Parahydroxybenzoate E216 0.015 % w/v
Sodium Metabisulphite E223
Sodium Citrate E331

4.4 Special warnings for each target species
Care should be taken to avoid the following practices because they increase the risk of development of resistance and
could ultimately result in ineffective therapy:
 Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
 Underdosing, which may be due to underestimation of body weight, misadministration of the product, or lack of
calibration of the dosing device (if any).
Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.
Milking cattle, particularly high yielders, may show a reduction in yield, occasionally of 5 % or more, for about 48
hours after handling.
The effect of this small loss may be minimised by spreading herd dosing over a period of about one week.

4.5 Special precautions for use
Special precaution(s) for use in animals

Care should be taken when administering by dosing gun.
Due regard must always be given to the physical condition of animals undergoing treatment, particularly those in
advanced pregnancy and/or under stress from adverse weather conditions, poor nutrition, penning, handling etc.

Special precautions to be taken by the person administering the veterinary medicinal product to animals
When using, do not eat, drink or smoke.
Wash splashes immediately from eyes and skin immediately.
Take off any contaminated clothing immediately.
Wash hands and exposed skin before meals and after work.

4.6 Adverse reactions (frequency and seriousness)
At normal oxyclozanide dose levels, cattle may show slight softening of the faeces with the occasional animal showing increased frequency of defaecation and transient inappetence.
These effects are occasionally enhanced in animals suffering from severe liver damage and/or dehydration at the time of dosing.

4.7 Use during pregnancy, lactation or lay
The product may be given to pregnant and lactating animals.
However, due regard must always be given to physical condition, particularly of any animals in advanced pregnancy, and/or under stress from adverse weather conditions, poor nutrition, penning, handling etc.

4.8 Interaction with other medicinal products and other forms of interaction
None known.

4.9 Amounts to be administered and administration route
Give as an oral drench.
Shake the product well before use.
To ensure administration of a correct dose, body weight should be determined as accurately as possible; accuracy of the dosing device should be checked.
If animals are to be treated collectively rather than individually, they should be grouped according to their bodyweight
and dosed accordingly, in order to avoid under- or overdosing.

Dose according to bodyweight at the rate of
10 mg oxyclozanide per kg bodyweight (cattle) and
15 mg oxyclozanide per kg bodyweight (sheep).

Cattle : 3 ml per 10 kg bodyweight;
For example:-
Bodyweight Dose
50 kg (approx 1 cwt) 15 ml
100 kg (approx 2 cwt) 30 ml
150 kg (approx 3 cwt) 45 ml
200 kg (approx 4 cwt) 60 ml
250 kg (approx 5 cwt) 75 ml
300 kg (approx 6 cwt) 90 ml
350 kg and over (7 cwt and over) 105 ml

Drench can be given in the feed to cattle which are fed individually.
Pour the recommended dose onto their concentrate ration.
Molasses or salt may be added for shy feeders.

Sheep:4.5 ml per 10 kg bodyweight
For example:-
Bodyweight Dose
10 kg (approx 22 lb) 4.5 ml
20 kg (approx 44 lb) 9 ml
30 kg (approx 66 lb) 13.5 ml
40 kg (approx 88 lb) 18 ml
45 kg and over (approx. 100 lb and over) 20 ml


4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
The effects of oxyclozanide overdosage are dullness and some loosening of faeces in sheep and possible diarrhoea,
inappetence and loss of weight in cattle.
These effects are occasionally enhanced in animals with severe liver damage and/or dehydration at the time of dosing.

4.11Withdrawal Period(s)
Cattle:
Meat and offal: 28 days.
Milk: 72 hours.
Sheep:
Meat and offal: 28 days.
Milk: Do not use in sheep producing milk for human consumption.

5 PHARMACOLOGICAL or IMMUNOLOGICAL PROPERTIES
Pharmacotherapeutic group: Anthelmintics; Oxyclozanide

ATCvet code:
QP52AG06.

 

5.1 Pharmacodynamic properties
Oxyclozanide is a salicylanide anthelmintic.
The mechanism of action is by uncoupling of oxidative phosphorylation in liver fluke.

5.2 Pharmacokinetic properties
Oxyclozanide is slowly absorbed after oral administration with peak plasma levels 24 hours after dosing.
Excretion is predominantly faecal, biliary excretion being the most important route of elimination (cattle studies only).

6 PHARMACEUTICAL PARTICULARS

6.1 List of excipients
Sodium Laurilsulphate
Methyl Parahydroxybenzoate (E218)
Propyl Parahydroxybenzoate (E216)
Aluminium Magnesium Silicate
Carmellose Sodium
Sodium Metabisulphite (E223)
Sodium Citrate
Purified Water

6.2 Incompatibilities
In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary
medicinal products.

6.3 Shelf-life
Shelf life of the veterinary medicinal product as packaged for sale: 5 years.

6.4 Special precautions for storage
Store below 25°C.
Protect from light.
Do not freeze.

6.5 Nature and composition of immediate packaging
High density polyethylene bottles of 1, 2.5, 5 and 10 litre nominal volume, and high density polyethylene back-packs
of 1, 2.5 and 5 litre nominal volume.
Closure: Polypropylene or urea formaldehyde screw cap with wads of PVDC-faced paper on a pulpboard liner.
Not all pack sizes may be marketed.

6.6 Special precautions for the disposal of unused veterinary medicinal products or waste materials
Unused product or waste material should be disposed of in accordance with current practice for pharmaceutical waste under national waste disposal regulations.
Do not contaminate ponds, waterways or ditches.

7 MARKETING AUTHORISATION HOLDER
Schering Plough Ltd.
Shire Park
Welwyn Garden City
Hertfordshire
AL7 1TW
England

8 MARKETING AUTHORISATION NUMBER(S)
VPA: 10277/043/001

9 DATE OF THE FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION
12th November 2010

 

Drench correctly
Sheep Oral Drench

The drenching technique is a vital part of ensuring that the wormer does its job effectively.
Make sure the sheep are properly restrained and cannot leap around when they are being drenched so they swallow the whole amount.
Sheep can also suffer serious injury, or even death, if they are unrestrained and the gun penetrates the tissues at the back of the mouth.
Place a hand under the head and tilt slightly to the side.
Slot the nozzle in the gap between molar and incisor teeth and then over the back of the tongue.
If the wormer is just put into the mouth, it will bypass the rumen as it escapes down the oesophageal groove and will be less effective.
This is particularly important for white (BZ) drenches.

Dosing Weigh – do not guess Underestimating the weight of sheep is a common cause of underdosing. Select and weigh the biggest sheep in the group to determine the correct dose. If there is a wide range of weights, consider splitting the group, then weigh the heaviest in each section. Do not forget to check that the weigh crate is accurate before starting!

Calibrate and maintain the drench gun
Always check the gun is delivering the right amount before you drench. Remove the plunger from a 10 ml syringe, put a thumb over the end and squirt the dose into it, making sure there are no air bubbles left. Adjust the gun until the dose delivered is correct. Drenching guns should also be well maintained and replaced regularly. Clean with warm soapy water after use and check springs and tubes to make sure there are no kinks that will form air bubbles.

Withholding food
Research has shown that the efficacy of the white (BZ) and clear (AV) drenches can be improved by withholding food for 12–24 hours before treatment. It is not advised to deprive heavily pregnant ewes of food, so if you treat this class of stock with anthelmintics, you may wish to use yellow drenches (LV) because their efficacy is less dependent on rumen fill.

Storage
Wormers should be stored securely, away from direct sunlight at 4–25°C. Check the use-by date and, once open, use within the time shown on the packaging. Shake white (BZ) products well before use.

 Cattle Oral drenches
Oral drenching guns are designed to deliver the treatment towards the back of the mouth over the tongue, so the entire dose is swallowed at once to optimise efficacy.
• Make sure animals are properly restrained, with their head held up
• Slide the nozzle of the dosing gun in the side of the mouth and over the tongue so that the entire dose is swallowed immediately
• Drenching equipment must be correctly calibrated and in good working order
• Calibrate the gun using the product just before treatment starts by delivering two or more doses into a graduated measuring cylinder. 
Faulty equipment, or attempting to dose too quickly, may mean that the barrel of the gun does not fill properly or that the liquid is full of bubbles.

Delivery Information

Delivery Service

Here at Agridirect we have joined forces with DPD to ensure all packages are delivered promptly and safely to you. We ship to all mainland countries within the EU. Deliveries take place Monday to Friday excluding bank holidays. Once your order has been dispatched from our warehouse you will be notified by email. If there is a delay with your order for any reason you will be contacted immediately. 

Due to Brexit we are temporarily unable to ship to the UK. Shipping to Northern Ireland will remain in place.

Delivery Times
Ireland (ROI & NI)EU (Mainland Only)
2-4 Working Days4-6 Working Days

Some product have an extended delivery time, this is noted on the products.

Delivery Rates

CountryOrders Under €99Orders Over €99
Ireland (ROI & NI)€6.99€0.00
Austria€19.99€13.00
Belgium€16.99€10.00
Czech Republic€19.99€13.00
Denmark€19.99€13.00
Finland€31.99€25.00
France€16.99€10.00
Germany€16.99€10.00
Hungary€23.99€17.00
Italy€29.99€23.00
Luxenburg€16.99€10.00
Netherlands€16.99€10.00
Poland€16.99€13.00
Portugal€31.99€25.00
Slovakia€23.99€17.00
Slovenia€23.99€17.00
Spain€29.99€23.00
Sweden€29.99€23.00

 

A selection of the products we sell are only licensed for sale within the Republic Of Ireland and can not be shipped outside of the country. These products are noted as only being available within the Republic of Ireland on the individual product pages.

There may be an addition charge on certain bulky items. This charge will be clearly marked on an applicable products and will be explained on the checkout page before payment has been made.

Agridirect Returns Policy

We’re sorry your purchase didn’t work out. But don’t worry; we have a great returns policy to help you out, plus returns are free.

All purchases can be returned to us within 14 days of delivery and returned goods must be received within 14 days from the date you informed us of the return.

Purchases may be opened for inspection but must not be used and must be repackaged securely in the original packaging if you wish to return it.
 

If we discover goods have been used or there has been a loss in value of the goods due to damage to the goods, while in your care or whilst being returned to us, we will reduce the amount refunded, which may amount to the full cost of the product, to cover loss of value of goods.

All returns should be complete which includes boxes, manuals and accessories that may have been included with the order.

All returns must be packaged appropriately for shipping, we will not accept responsibility for damages or loss which occur during shipping of a return product.

We accept no responsibility for goods damaged or lost while in transit to us. 

How do I return a product?

Making returns to us are free, simply follow the steps below and bring your package to an official DPD pickup point.

  • All returns must be accompanied with a fully filled out returns form which can be downloaded here.
  • To print off your return label click here or visit www.dpd.ie/returns and follow the on-screen instructions. Make sure and use your order number as your reference.
  • Bring your package to a DPD pickup point. To find your nearest drop off point here.

Once the returned product has been received into our warehouse and been fully inspected a refund will be issued.

For the return of bulk products please contact us at sales@agridirect.ie

I have received a damaged product from you, what should I do?

First off, if you have received a damaged electrical product from us, do not plug it in. Any electrical products that are plugged in are deemed ‘as used and accepted’ and are not accepted as returns. All damages must be reported to us via phone or email within 24hours of receipt of goods. Please ensure you check your items upon delivery.

How do I begin the returns process?

If you wish to begin the return process, please email us at sales@agridirect.ie and ensure the following information is included in your email. Your name, phone number, Order id, the item you wish to return, reason for return and if the product is damaged we require photos of the product.

Once you have sent us all required information a member of our team will assess your claim and will contact you as soon as possible. Please hold off on returning products until a member of our team has called you to confirm.

Refunds

Once the returned product has been returned to us and fully inspected a refund will be issued.

Please Note: A typical timeline for a refund to show in your account is up to 10 working days from the date processed, depending on your bank.

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