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Flukiver Injection 250ml (Closantel)
Flukiver Injection 250ml (Closantel)

Flukiver Injection 250ml (Closantel)

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32.00
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Flukiver Injection is used for the treatment and control of liver fluke in cattle.

Active Ingredient: Closantel

Target Species: Cattle

Administration Method: Subcutaneous injection (under the skin)

Treats and Controls: Liver fluke in cattle

Withdrawal Time:77 days for animals intended for meat and offal, not permitted for use on animals producing milk for human consumption.

Dosage For Cattle:2.5 ml per 50 kg of bodyweight.

Weight in kgDosage in mlDoses in 250 ml Bottle
Up to 502.5100
51 - 1005.050
101 - 1507.533
151 - 20010.025
201 - 25012.520
251 - 30015.016
301 - 35017.514
351 - 40020.0012
401 - 45022.511
451 - 50025.010
501 - 55027.59

 

Always read the label and all enclosed information for Flukiver Injection before administering to animals!

Key Features of Flukiver:

  • When used in the treatment of culling cows they can grow up to 10 kg heavier
  • Treated herds can produce an extra 1-3% more calves
  • Calves whose mothers have been treated are on average 20 kg heavier at the time of weaning
  • Fluke egg laying is reduced for 13 weeks, this is longer than any other flukicide
  • Fluke egg hatchability is highly reduced
 
Identifying infected cattle:
 
It can sometimes be hard to see the signs of fluke in infected cattle and a slight decline in the performance of the herd can be hard to associate to a single factor. Yet liver fluke affects at least 50% of all Irish herds. The following list will show some of the common signs that your herd has been infected by liver fluke.

 

 
In Young Stock
  • Weakened calves
  • Reduced weight at the time of weaning caused by both the poor quality and quantity of the milk being produced
  • Poor feed conversion
  • On occasion, anaemia, loss of weight and even death in animals younger than 2 years old.
In Breeding Stock
  • Weakened or incapacitated cows, especially in later stages of pregnancy.
  • Lower fertility rates which leads an increase in culls
  • Sale weight of cull cows reduced
  • Production of milk is greatly reduced
  • Reduction in the nutritional value of the milk
  • Lower conception rates
  • Slower growth in heifers
  • Delay in the onset of first oestrus in the herd
  • Poor reproductive performance from bulls
"It's time to revise your tactics for fluke control"
 
This product is only licensed for sale within the Republic of Ireland

Click here to Download Data Sheet

Health Products Regulatory Authority 

Summary of Product Characteristics

1 NAME OF THE VETERINARY MEDICINAL PRODUCT
Flunixin Injection

2 QUALITATIVE AND QUANTITATIVE COMPOSITION

Active Substance
Flunixin (as flunixin meglumine) 50 mg/ml

Excipients
Phenol 5.0 mg/ml
Sodium formaldehyde Sulphoxylate Dihydrate 2.5 mg/ml

For a full list of excipients, see section 6.1

3 PHARMACEUTICAL FORM
A sterile aqueous solution for injection.

4 CLINICAL PARTICULARS

4.1 Target Species


Cattle, horses and pigs

4.2 Indications for use, specifying the target species

Flunixin Injection is indicated for use in cattle and horses in the alleviation of inflammation and pain.
In the horse, Flunixin Injection is indicated for the alleviation of inflammatory signs associated with musculo-skeletal disorders and for the alleviation of visceral pain associated with colic.
In cattle, Flunixin Injection is indicated for the control of acute inflammation associated with respiratory disease.

Flunixin Injection has also been shown to have some benefit in the treatment of acute pulmonary emphysema [fog fever] and as adjunctive therapy in the treatment of acute mastitis.

In pigs, Flunixin Injection is indicated as an adjunctive therapy in the treatment of swine respiratory diseases.

4.3 Contraindications
Do not exceed the recommended dose or duration of treatment.
Do not administer to pregnant mares.
Use is contraindicated in animals suffering from cardiac, hepatic or renal disease, where there is the possibility of gastro-intestinal ulceration or bleeding, where there is evidence of a blood dyscrasia or hypersensitivity to the product.

4.4 Special warnings for each target species
The cause of the underlying inflammatory condition or colic should be determined and treated with appropriate concomitant therapy. 

4.5 Special precautions for use Special precautions for use in animals
Avoid intra-arterial injection. Use in any animals less than 6 weeks of age or in aged animals may involve additional risk. If such use cannot be avoided animals may require careful clinical management.
Avoid use in any dehydrated, hypovalaemic or hypotensive animal except in the case of endotoxaemia or septic shock. It is preferable that NSAIDs which inhibit prostaglandin synthesis are not administered to animals undergoing general anaesthesia until fully recovered.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

Flunixin meglumine is irritating to the eye.
Avoid contact with the skin and splashes to the eye.

4.6 Adverse reactions (frequency and seriousness)

For this class of drug, untoward effects include gastrointestinal irritation, ulceration and, in dehydrated or hypovolaemic animals, potential for renal damage.
There are occasional reports of collapse following rapid intravenous injection in horses and calves.

4.7 Use during pregnancy, lactation or lay

Flunixin Injection may be used in pregnant and lactating cattle.
Do not administer Flunixin Injection to pregnant mares or pregnant sows.
Safety studies in pregnant mares or pregnant sows have not been conducted.

4.8 Interaction with other medicinal products and other forms of interactions

Monitor drug compatibility closely where adjunctive therapy is required.
Do not administer other non-steroidal anti-inflammatory drugs (NSAIDs) concurrently or within 24 hours of each other. Some NSAIDs may be highly bound to plasma proteins and compete with other highly bound drugs which can lead to toxic effects.
Concurrent administration of potentially nephrotoxic drugs should be avoided.

4.9 Amounts to be administered and administration route

Flunixin Injection is indicated for intravenous administration to cattle and horses and intramuscular injection to pigs.

Horses:
For use in equine colic, the recommended dose rate is 1.1 mg flunixin/kg bodyweight equivalent to 1 ml per 45 kg bodyweight. Treatment may be repeated once or twice if colic recurs.
During clinical trials, approximately 10% of the horses required one or two additional treatments. The cause of colic should be determined and treated with concurrent therapy.
For use in musculo-skeletal disorders, the recommended dose rate is 1.1 mg flunixin/kg bodyweight equivalent to 1 ml per 45 kg bodyweight, once daily for up to 5 days according to clinical response.

Cattle:
For use in acute inflammatory conditions, the recommended dose rate is 2.2 mg flunixin/kg bodyweight equivalent to 2 ml per 45 kg bodyweight. Repeat as necessary at 24 hour intervals for up to 5 consecutive days. 

Pigs:
For use in pigs, the recommended dose rate is 2.2 mg flunixin/kg bodyweight equivalent to 2 ml per 45 kg bodyweight once by intramuscular injection. Flunixin Injection should be administered as adjunctive therapy in conjunction with a suitable course of antibacterial therapy.

4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
In common with other drugs in this class, overdose is associated with gastrointestinal toxicity.

4.11 Withdrawal period(s)
Meat: Animals must not be slaughtered for human consumption during treatment.
Horses and cattle intended for human consumption may be slaughtered 7 days following treatment.
Pigs intended for human consumption may be slaughtered 24 days following treatment.

Milk for human consumption must not be taken during treatment.
Milk: 36 hours.
Milk intended for human consumption may only be taken from treated cows after 36 hours from the last treatment.

5 PHARMACOLOGICAL or IMMUNOLOGICAL PROPERTIES

Pharmacotherapeutic group
:
non-steroidal anti-inflammatory drug

ATC vet code:

QM01AG90

5.1 Pharmacodynamic properties
Flunixin meglumine is a relatively potent non-narcotic, non-steroidal analgesic with anti-inflammatory, anti-endotoxic and anti-pyretic properties.
Flunixin meglumine acts as a reversible inhibitor of cyclo-oxygenase, an important enzyme in the arachidonic acid cascade pathway which is responsible for converting arachidonic acid to cyclic endoperoxides. Consequently, synthesis of eicosanoids, important mediators of the inflammatory process involved in central pyresis, pain perception and tissue inflammation, is inhibited.
Through its effects on the arachidonic acid cascade, flunixin also inhibits the production of thromboxane, a potent platelet pro-aggregator and vasoconstrictor which is released during blood clotting.
Flunixin exerts its antipyretic effect by inhibiting prostaglandin E2 synthesis in the hypothalamus.
By inhibiting the arachidonic acid cascade pathway, flunixin also produces an anti-endotoxic effect by suppressing eicosanoid formation and therefore preventing their involvement in anti-endotoxin associated disease states.

5.2 Pharmacokinetic particulars
Flunixin was administered intravenously to horses as a single dose of 1.1 mg/kg.
At the first timepoint measured (10 minutes after administration) the plasma concentration was 11.45 micrograms/ml and the elimination half-life was approximately 2 hours.
Flunixin was administered intravenously to cattle as a single dose of 2.2 mg/kg.
At the first timepoint measured (10 minutes after administration) the plasma concentration was 12.32 micrograms/ml and the elimination half-life was approximately 4 hours.

6 PHARMACEUTICAL PARTICULARS

6.1 List of excipients

Phenol
Sodium formaldehyde sulphoxylate dihydrate
Disodium Edetate
Sodium hydroxide
Propylene Glycol
Hydrochloric Acid Water for Injections 

6.2 Major incompatibilities

None known.

6.3 Shelf-life
3 years. Following withdrawal of the first dose the product should be used within 28 days.

6.4 Special precautions for storage
Do not store above 25°C.
Protect from light.

6.5 Nature and composition of immediate packaging
Flunixin Injection is supplied in 50ml and 100ml type I clear glass vials, complete with bromobutyl bungs and aluminium caps.

6.6 Special precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products

Unused product or waste material should be disposed of in accordance with current practice for pharmaceutical waste under national waste disposal regulations.

7 MARKETING AUTHORISATION HOLDER
Norbrook Laboratories (Ireland) Limited
Rossmore Industrial Estate
Monaghan
Ireland

8 MARKETING AUTHORISATION NUMBER(S)
VPA22664/046/001

9 DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION
Date of first authorisation: 23rd April 1997
Date of last renewal: 22nd April 2007

10 DATE OF REVISION OF THE TEXT
August 2019

 Cattle Injectables
Injectables should be given according to the manufacturer’s instructions at the recommended injection site.
• Always use a clean, sterile syringe and needle. If using a multiple injection gun, ensure the needle is disinfected between injections, e.g. with an automatic sterilisation system.
• If the site to be injected is dirty, clean the skin and swab with an alcohol-impregnated wipe or cotton wool.
• Before injecting, check the expiry date and read the instructions of the product to be used. Some products need to be shaken before use.
• Use the correct-sized needle according to the size of the animal and site of injection.
• Ensure the animal is adequately restrained before attempting the injection.
• Take care to ensure it is given subcutaneously and not intramuscularly. Raise a fold of skin at the injection site (mainly neck but some are ear) recommended by the product manufacturer and inject carefully into the space created.
• If a large dose is to be delivered, it may be advisable to split the dose between two injection sites. After the injection, briefly massage the site to improve the dispersal of the injected material.
• Dispose of the needle and syringe in appropriate clinical waste and sharps containers.

Delivery Information

Delivery Service

Here at Agridirect we have joined forces with DPD to ensure all packages are delivered promptly and safely to you. We ship to all mainland countries within the EU. Deliveries take place Monday to Friday excluding bank holidays. Once your order has been dispatched from our warehouse you will be notified by email. If there is a delay with your order for any reason you will be contacted immediately. 

Due to Brexit we are temporarily unable to ship to the UK. Shipping to Northern Ireland will remain in place.

Delivery Times
Ireland (ROI & NI)EU (Mainland Only)
2-4 Working Days4-6 Working Days

Some product have an extended delivery time, this is noted on the products.

Delivery Rates

CountryOrders Under €99Orders Over €99
Ireland (ROI & NI)€6.99€0.00
Austria€19.99€13.00
Belgium€16.99€10.00
Czech Republic€19.99€13.00
Denmark€19.99€13.00
Finland€31.99€25.00
France€16.99€10.00
Germany€16.99€10.00
Hungary€23.99€17.00
Italy€29.99€23.00
Luxenburg€16.99€10.00
Netherlands€16.99€10.00
Poland€16.99€13.00
Portugal€31.99€25.00
Slovakia€23.99€17.00
Slovenia€23.99€17.00
Spain€29.99€23.00
Sweden€29.99€23.00

 

A selection of the products we sell are only licensed for sale within the Republic Of Ireland and can not be shipped outside of the country. These products are noted as only being available within the Republic of Ireland on the individual product pages.

There may be an addition charge on certain bulky items. This charge will be clearly marked on an applicable products and will be explained on the checkout page before payment has been made.

Agridirect Returns Policy

We’re sorry your purchase didn’t work out. But don’t worry; we have a great returns policy to help you out, plus returns are free.

All purchases can be returned to us within 14 days of delivery and returned goods must be received within 14 days from the date you informed us of the return.

Purchases may be opened for inspection but must not be used and must be repackaged securely in the original packaging if you wish to return it.
 

If we discover goods have been used or there has been a loss in value of the goods due to damage to the goods, while in your care or whilst being returned to us, we will reduce the amount refunded, which may amount to the full cost of the product, to cover loss of value of goods.

All returns should be complete which includes boxes, manuals and accessories that may have been included with the order.

All returns must be packaged appropriately for shipping, we will not accept responsibility for damages or loss which occur during shipping of a return product.

We accept no responsibility for goods damaged or lost while in transit to us. 

How do I return a product?

Making returns to us are free, simply follow the steps below and bring your package to an official DPD pickup point.

  • All returns must be accompanied with a fully filled out returns form which can be downloaded here.
  • To print off your return label click here or visit www.dpd.ie/returns and follow the on-screen instructions. Make sure and use your order number as your reference.
  • Bring your package to a DPD pickup point. To find your nearest drop off point here.

Once the returned product has been received into our warehouse and been fully inspected a refund will be issued.

For the return of bulk products please contact us at sales@agridirect.ie

I have received a damaged product from you, what should I do?

First off, if you have received a damaged electrical product from us, do not plug it in. Any electrical products that are plugged in are deemed ‘as used and accepted’ and are not accepted as returns. All damages must be reported to us via phone or email within 24hours of receipt of goods. Please ensure you check your items upon delivery.

How do I begin the returns process?

If you wish to begin the return process, please email us at sales@agridirect.ie and ensure the following information is included in your email. Your name, phone number, Order id, the item you wish to return, reason for return and if the product is damaged we require photos of the product.

Once you have sent us all required information a member of our team will assess your claim and will contact you as soon as possible. Please hold off on returning products until a member of our team has called you to confirm.

Refunds

Once the returned product has been returned to us and fully inspected a refund will be issued.

Please Note: A typical timeline for a refund to show in your account is up to 10 working days from the date processed, depending on your bank.

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