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Flukiver Injection 250ml (Closantel)

Flukiver Injection 250ml (Closantel)

was: €~~productWasPrice~~Our Price: 34.00111101
Availability: In Stock
Delivery Time: 2-4 Days
Information

Flukiver Injection is used for the treatment and control of liver fluke in cattle and sheep. It is also targets the larval stage of nasal bots in sheep.

Active Ingredient:Closantel

Target Species: Cattle, sheep

Treats and Controls: Liver fluke in sheep and cattle, larval stage nasal bots in sheep

Administration Method: Subcutaneous injection (under the skin)

Withdrawal Time:77 days for animals intended for meat and offal, not permitted for use on animals producing milk for human consumption.

Dosage For Cattle:2.5 ml per 50 kg of bodyweight.

Weight in kgDosage in mlDoses in 250 ml Bottle
Up to 502.5100
51 - 1005.050
101 - 1507.533
151 - 20010.025
201 - 25012.520
251 - 30015.016
301 - 35017.514
351 - 40020.0012
401 - 45022.511
451 - 50025.010
501 - 55027.59

 

Dosage for sheep: 1 ml per 10 kg of bodyweight.

Weight in KgDosage in mlDoses per 250 ml Bottle
151.5166
202.0125
252.5100
303.083
353.571
404.062
454.555
505.050
555.545

Always read the label and all enclosed information for Flukiver Injection before administering to animals!

Benifits of using Flukiver for the treatment of parasites:

  • When used in the treatment of culling cows they can grow up to 10 kg heavier
  • Treated herds can produce an extra 1-3% more calves
  • Calves whose mothers have been treated are on average 20 kg heavier at the time of weaning
  • Fluke egg laying is reduced for 13 weeks, this is longer than any other flukicide
  • Fluke egg hatchability is highly reduced
 
Identifying infected cattle:
 
It can sometimes be hard to see the signs of fluke in infected cattle and a slight decline in the performance of the herd can be hard to associate to a single factor. Yet liver fluke affects at least 50% of all Irish herds. The following list will show some of the common signs that your herd has been infected by liver fluke.

 

 
In Young Stock
  • Weakened calves
  • Reduced weight at the time of weaning caused by both the poor quality and quantity of the milk being produced
  • Poor feed conversion
  • On occasion, anaemia, loss of weight and even death in animals younger than 2 years old.
In Breeding Stock
  • Weakened or incapacitated cows, especially in later stages of pregnancy.
  • Lower fertility rates which leads an increase in culls
  • Sale weight of cull cows reduced
  • Production of milk is greatly reduced
  • Reduction in the nutritional value of the milk
  • Lower conception rates
  • Slower growth in heifers
  • Delay in the onset of first oestrus in the herd
  • Poor reproductive performance from bulls
"It's time to revise your tactics for fluke control"
 
This product is only licensed for sale within the Republic of Ireland
Data Sheet

1 NAME OF THE VETERINARY MEDICINAL PRODUCT
Flukiver 50 mg/ml Solution for Injection

2 QUALITATIVE AND QUANTITATIVE COMPOSITION
Active Substance
Closantel (as Closantel sodium) 50 mg/ml
Excipients
For a full list of excipients, see section 6.1.

3 PHARMACEUTICAL FORM
Solution for injection

4 CLINICAL PARTICULARS
4.1 Target Species
Sheep, cattle.

4.2 Indications for use, specifying the target species
Sheep
Trematodes
Fasciola hepatica
Fasciola gigantica
Nematodes
Haemonchus contortus (including benzimidazole-resistant strains)
Oesophagostomum columbianum
Gaigeria pachyscelis
Chabertia ovina
Arthropods
Oestrus ovis
Cattle
Trematodes
Fasciola hepatica
Fasciola gigantica
Nematodes
Haemonchus placei
Bunostomum phlebotomum
Oesophagostomum radiatum
Arthropods
Hypoderma bovis
Hypoderma lineatum

4.3 Contraindications
None.

4.4 Special warnings for each target species
Do not exceed the stated dose.
Care should be taken to ensure that all injection procedures are correctly carried out and body weights accurately
assessed.
Care should be taken to avoid the following practices because they increase the risk of development of resistance and
could ultimately result in ineffective therapy:
- Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
- Underdosing, which may be due to underestimation of body weight, misadministration of the product, or lack of
calibration of the dosing device.
Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal
Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an
anthelmintic belonging to another pharmacological class and having a different mode of action should be used.

4.5 Special precautions for use
Special precautions for use in animals
None
Special precautions to be taken by the person administering the veterinay medicinal product to animals
Wash hands after administration. Take care to avoid accidental self-administration.

4.6 Adverse reactions (frequency and seriousness)
The solution contains polyvidone. This substance may in very exceptional cases induce hyperacute anaphylactic reactions
in cattle.

4.7 Use during pregnancy, lactation or lay
Flukiver 50 mg/ml Solution for Injection is safe for use during pregnancy and lactation. See section 4.11.

4.8 Interaction with other medicinal products and other forms of interaction
None known.

4.9 Amounts to be administered and administration route
Ticks (Ixodes ricinus) feeding on sheep at the time of treatment ate likely to produce fewer viable eggs.
*average efficacy against 6 week immature stages of Fasciola hepatica is 86% in sheep.
Cattle
*average efficacy against 6 week immature stages of Fasciola hepatica is 73% in cattle.
Because of its long half-life, closantel will protect for several weeks against re-infections with the following
nematodes:
2.5 mg/kg sc (1 ml/20 kg BW) Adults Immatures
Haemonchus contortus X X
Gaigeria pachyscelis X X
Oestrus ovis 1st, 2nd and 3rd instar
5 mg/kg sc (1 ml/10 kg BW) Adults Immatures
Fasciola hepatica X 6 weeks*
Fasciola gigantica X 8 weeks
Haemonchus contortus (+ BZ-resistant
strains)
X X
Chabertia ovina X X
Oesophagostomum columbianum X X
2.5 mg/kg sc (1 ml/20 kg BW) Adults Immatures
Fasciola hepatica X
Fasciola gigantica X
Haemonchus placei X X
Bunostomum phlebotomum X
Oesophagostomum radiatum X
5 mg/kg sc (1 ml/10 kg BW) Adults Immatures
Fasciola hepatica X 6 weeks*
Fasciola gigantica X 8 weeks*
Haemonchus placei X X
Bunostomum phlebotomum X X
Oesophagostomum radiatumX X
Hypoderma bovis Dermal stages
Hypoderma lineatum Dermal stages
Sheep
Cattle
Method of administration
Flukiver 50 mg/ml Solution for Injection is to be given by the subcutaneous route. Inject cattle under the loose skin of
the neck and sheep behind the shoulder. To ensure administration of a correct dose, body weight should be determined
as accurately as possible.
When large volumes have to be injected (more than 20 ml), divide the total volume equally over both neck sizes.

4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
Symptoms of acute overdosage are decreased vision or blindness, anorexia, incoordination and general weakness.

4.11 Withdrawal Period(s)
A period of 77 days should be observed between the last administration of the drug and the time of slaughtering of animals
for human consumption.
Not authorised for use in cattle producing milk for human consumption including during the dry period. Do not use during
the last trimester of pregnancy in heifers which are intended to produce milk for human consumption.
Not authorised for use in ewes producing milk for human consumption including during the dry period. Do not use within
1 year prior to the first lambing in ewes intended to produce milk for human consumption.

5 PHARMACOLOGICAL or IMMUNOLOGICAL PROPERTIES
Pharmacotherapeutic group: Anthelmintics, phenol derivatives, including salicylanilides
ATCvet Code: QP52AG09
Residual Activity Dose (mg/kg) Protection Period
Haemonchus contortus 2.5 2 weeks
5 7 weeks
Gaigeria pachyscelis 2.5 3 weeks
5 8 weeks
Oestrus ovis 5 8 weeks
Residual Activity Dose (mg/kg) Protection Period
Haemonchus placei 2.5 4 weeks
5 6 weeks
Bunostomum phlebotom 5 3 weeks
Oesophagostomum radiatum 5 2 weeks

5.1 Pharmacodynamic properties
Flukiver 50 mg/ml Solution for Injection contains the salicylanilide closantel, a synthetic antiparasitic agent with high
efficacy against liver fluke, haematophagous nematodes and larval stages of some arthropods in sheep and cattle. Ticks
feeding on sheep at the time of treatment are likely to produce fewer viable eggs
Closantel is an uncoupler of mitochondrial oxidative phosphorylation resulting in inhibition of ATP synthesis. This induces
a marked change in the energy metabolism and finally leads to death of the parasite.

5.2 Pharmacokinetic properties
Closantel is rapidly absorbed into the systemic circulation with peak plasma levels at 24-48 hours after dosing. In plasma,
closantel is bound 99% to albumin. As a result, tissue distribution is very limited. On average, tissue levels are 15 times
lower than plasma levels. The elimination half-life of closantel from plasma and tissues is approximately 2 to 4 weeks in
sheep and 9 to 21 days in cattle. The drug is poorly metabolised and the main excretion route is in the faeces via the bile.
Urinary excretion in negligible.

6 PHARMACEUTICAL PARTICULARS
6.1 List of excipients
Propylene Glycol
Povidone
Citric AcidMonohydrate
Sodium Hydroxide
Citric Acid
Water for Injections

6.2 Incompatibilities
None known.

6.3 Shelf-life
Shelf-life of the veterinary medicinal product as packaged for sale: 36 months.
Shelf-life after first opening the immediate packaging: 28 days

6.4 Special precautions for storage
Do not store above 25oC.
Protect from light.

6.5 Nature and composition of immediate packaging
Container or pack size: 1 or 4 amber Type I glass vials.
Closure: Grey bromobutyl siliconised rubber stopper.
Cap: Red coloured aluminium.
Contents of each vial: 250 ml aqueous solution.
Not all pack sizes may be marketed.

6.6 Special precautions for the disposal of unused veterinary medicinal products or waste materials
Any unused product or waste materials should be disposed of in accordance with national requirements.
Flukiver 50 mg/ml Solution for Injection should not enter water courses as this may be dangerous to fish and other
aquatic organisms.

7 MARKETING AUTHORISATION HOLDER
Eli Lilly & Company Limited
Elanco Animal Health
Lilly House
Priestly Road
Basingstoke
Hampshire
RG24 9N

8 MARKETING AUTHORISATION NUMBER(S)
VPA 10047/034/001

9 DATE OF THE FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION
30th September 2009

10 DATE OF REVISION OF THE TEXT
February 2013

Delivery

 

Delivery Information

Here at Agridirect we have joined forces with DPD to ensure all packages are delivered promptly and safely to you. We ship to all mainland countries within the EU. Deliveries take place Monday to Friday excluding bank holidays. Once your order has been dispatched from our warehouse you will be notified by email. If there is a delay with your order for any reason you will be contacted immediately. 

Delivery Times
Ireland (ROI & NI)United Kingdom (Mainland Only)EU (Mainland Only)
1-3 Working Days2-4 Working Days4-6 Working Days

Some product have an extended delivery time, this is noted on the products.

Delivery Rates

Delivery Rates
CountryOrders Under €70Orders Over €70
Ireland (ROI & NI)€4.99€0.00
Austria€17.99€13.00
Belgium€14.99€10.00
Czech Republic€17.99€13.00
Denmark€17.99€13.00
Finland€29.99€25.00
France€14.99€10.00
Germany€14.99€10.00
Hungary€21.99€17.00
Italy€27.99€23.00
Luxenburg€14.99€10.00
Netherlands€14.99€10.00
Poland€14.99€13.00
Portugal€29.99€25.00
Slovakia€21.99€17.00
Slovenia€21.99€17.00
Spain€27.99€23.00
Sweden€27.99€23.00
United Kingdom (Mainland Only)€14.99€10.00

 

 

A selection of the products we sell are only licensed for sale within the Republic Of Ireland and can not be shipped outside of the country. These products are noted as only being available within the Republic of Ireland on the individual product pages

There may be an addition charge on certain bulky items. This charge will be clearly marked on an applicable products and will be explained on the checkout page before payment has been made.

 

Returns

Returns Policy

We’re sorry your purchase didn’t work out. But don’t worry; we have a great returns policy to help you out.
 

All purchases can be returned to us within 14 days of delivery and returned goods must be received within 14 days from the date you informed us of the return.
 

Purchases may be opened for inspection but must not be used and must be repackaged securely in the original packaging if you wish to return it.
 

If we discover goods have been used or there has been a loss in value of the goods due to damage to the goods, while in your care or whilst being returned to us, we will reduce the amount refunded, which may amount to the full cost of the product, to cover loss of value of goods.
 

We accept no responsibility for goods damaged or lost while in transit to us. 
 

The cost of the return, including all packaging and freight, lies solely with the consumer.
 

I have received a damaged product from you, what should I do?

First off, if you have received a damaged electrical product from us, do not plug it in. Any electrical products that are plugged in are deemed ‘as used and accepted’ and are not accepted as returns. All damages must be reported to us via phone or email within 24hours of receipt of goods. Please ensure you check your items upon delivery.

How do I begin the returns process?

If you wish to begin the return process, please email us at sales@agridirect.ie and ensure the following information is included in your email. Your name, phone number, Order id, the item you wish to return, reason for return and if the product is damaged we require photos of the product.

Once you have sent us all required information a member of our team will assess your claim and will contact you as soon as possible. Please hold off on returning products until a member of our team has called you to confirm.

 

Packaging

All returns must be the complete product which includes boxes, manuals and accessories that may have been include with the order.

All returns must be packaged appropriately for shipping, we will not accept responsibility for damages or loss which occur during shipping of a return product.
 

Address: Please ship the product to the following address: Agridirect, Drumrahan Retail, Church Street, Ballyconnell, Co Cavan
 

Refunds

Once the returned product has been returned to us and fully inspected a refund will be issued.

Please Note: A typical timeline for a refund to show in your account is up to 10 working days from the date processed, depending on your bank.


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