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Tribex 10% (Triclabendazole)
Tribex 10% (Triclabendazole)
Tribex 10% (Triclabendazole)

Tribex 10% (Triclabendazole)

was: €~~productWasPrice~~Our Price: 42.00

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Delivery Time: 2-4 Days
Information

Tribex 10% is an oral drench for cattle that is used for the treatment and control of all three stages of liver fluke, mature, immature and early immature.

Active Ingredient: Triclabendazole

Target Species: Cattle

Treats and Controls: Mature, immature and early immature liver fluke

Administration Method: Oral Drench

Withdrawal Time: 56 days for animals intended for meat and offal. The product is not permitted for use during lactation in animals producing milk for human consumption. When used in non-lactating cattle: Milk for human consumption may only be taken from 84 hours after calving. Not intended for use within 41 days of calving. If calving occurs before 41 days after treatment, milk for human consumption may only betaken after 41 days plus 84 hours after the treatment.

Dosage:6 ml per 50 kg of bodyweight

Body WeightDose VolumeNumber of full doses per pack:
800 ml5 Liter
50kg6 ml133833
100kg12 ml67417
150kg18 ml44278
200kg24 ml33208
250kg30 ml27167
300kg36 ml22139
350kg42 ml19119
400kg48 ml17104
450kg54 ml1593
500kg60 ml1383
550kg66 ml1276
600kg72 ml1179

Always read the label and all enclosed information for Tribex 10% before administering to animals!

How Livestock Contracts Liver Fluke

Animals are infected by ingesting encapsulated larvae (metacercariae) on contaminated grass. Typically,individual farms will have wet “flukey areas” that should not be used or grazed at times of the year whenmetacercariae are likely to be present, i.e. late summer to winter (depending on climatic conditions). However,cattle and sheep often graze on such areas. Therefore, it cannot be assumed that liver fluke infection is absentfrom any area of Ireland.

This product is only licensed for sale within the Republic of Ireland

Data Sheet

Summary of Product Characteristics

1 NAME OF THE VETERINARY MEDICINAL PRODUCT
Tribex 10% Oral Suspension for Cattle

2 QUALITATIVE AND QUANTITATIVE COMPOSITION
Each ml contains
Active substance:
Triclabendazole 100 mg
Excipient(s):
Methyl Parahydroxybenzoate (E2I8) 2.0 mg
Propyl Parahydroxybenzoate (E216) 0.2 mg
Carmoisine supra (EB122). 22.5 mg
For a full list of excipients, see section 6.13 PHARMACEUTICAL FORM
Oral suspension
An aqueous pink-coloured suspension

4 CLINICAL PARTICULARS
4.1 Target Species
Cattle

4.2 Indications for use, specifying the target species
The product is indicated for the treatment of acute, sub-acute and chronic fasciolosis in cattle caused by early immature, immature
and adult stages of liverfluke (Fasciola hepatica) susceptible to triclabendazole.

4.3 Contraindications
Do not use in cases of known hypersensitivity to the active ingredient

4.4 Special warnings for each target species
None
Each ml contains
Active substance:
Triclabendazole 100 mg
Excipient(s):
Methyl Parahydroxybenzoate (E2I8) 2.0 mg
Propyl Parahydroxybenzoate (E216) 0.2 mg
Carmoisine supra (EB122). 22.5 mg
For a full list of excipients, see section 6.1

4.5 Special precautions for use
Special precautions for use in animals.
Only use for liver fluke strains susceptible to triclabendazole. Frequent and repeated use may lead to the development
of resistance. Care must be taken not to damage the mouth or pharyngeal region when dosing. Clean drenching
equipment before and after use. Use unaltered product from the original container.
Special precautions to be taken by the person administering the veterinary medicinal product to animals.
When using the product do not eat, drink or smoke, Wear gloves. Wash splashes from eyes and skin immediately. Take
off any contaminated clothing immediately. Wash hands and exposed skin before meals and after work. In cases of
hypersensitivity and contact allergy, direct skin contact and inhalation should be avoided.

4.6 Adverse reactions (frequency and seriousness)
None known

4.7 Use during pregnancy, lactation or lay
The product is safe for use during pregnancy. However, the product is not permitted for use in animals producing milk
for human consumption, including pregnant animals intended to produce milk for human consumption.

4.8 Interaction with other medicinal products and other forms of interaction
None known.

4.9 Amounts to be administered and administration route
For oral administration only, using properly calibrated dosing equipment. Estimate
bodyweight accurately. Shake container before use.
Recommended dose rate: 12 mg triclabendazole per kg bodyweight as a single administration.
DOSAGE GUIDE:
For animals over 400 kg - give an additional 6 ml for each additional 50 kg bodyweight
DOSING PROGRAMME:
Routine treatment (Areas of heavy fluke infection)
As a guide, dose all cattle exposed to fluke infected pastures preventatively at regular intervals of 10 weeks from March/April
through to October/November. In situations where stock are out-wintered, another dose in January may be required. All animals
grazing the pasture should be treated at these times. All bought in animals should be dosed before joining the main flock.
Veterinary advice should be sought with regard to specific preventative dosing regimes.
Routine treatment (Areas of moderate fluke infection)
Dose all cattle on fluke infected pastures at intervals of 10 weeks throughout the fluke season, usually September to January/
February. An additional preventative treatment in the spring will assist in reducing the amount of new infestation on the pastures
in the following autumn. All bought in animals should be dosed before joining the main herd.
In-wintered cattle
Where cattle are in-wintered, a single dose of the product should be given 2 weeks after housing.
Treatment of sub-acute and acute outbreaks
Affected cattle should be treated immediately after diagnosis and veterinary advice should be sought for subsequent dosing
intervals. If a preventative fluke dosing programme is employed, the occurrence of acute fluke is greatly reduced.

4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
No adverse effects were reported following a 3-fold overdose in cattle. A single dose of 200 mg/kg causes inappetence, transient
weight loss and slight effects on motor activity and serum glucose lactate dehydrogenase (GLDH) in calves.

4.11Withdrawal Period(s)
Meat and offal: 56 days.The product is not permitted for use during lactation in animals producing milk for human consumption. When used innon-lactating cattle: Milk for human consumption may only be taken from 84 hours after calving. Not intended for usewithin 41 days of calving. If calving occurs before 41 days after treatment, milk for human consumption may only betaken after 41 days plus 84 hours after the treatment. 
5 PHARMACOLOGICAL or IMMUNOLOGICAL PROPERTIES
Pharmacotherapeutic group: Anthelmintics, Benzimidazoles and related substances
ATC vet-code: QP52ACOI
Bodyweight Dosage Bodyweight Dosage
Up to 50 kg
100 kg
150 kg
200 kg
6 ml
12 ml
18 ml
24 ml
250 kg
300 kg
350 kg
400 kg
30 ml
36 ml
42 ml
48 ml

5.1 Pharmacodynamic properties
Triclabendazole differs from other benzimidazoles in that it is a narrow spectrum anthelmintic. The drug accumulates
significantly in both immature and adult stages of Fasciola hepatica and stimulates the major routes of the parasite’s energy
generating system, as demonstrated by glucose derived acetate and propionate formation. However, under these conditions the
parasite’s motility decreased, indicating that the drug is not associated with inhibition of the energy generating pathways.
Triclabendazole inhibits colchicine binding to microtubular proteins suggesting interference of the drug with microtubular
structure and function. The drug strongly inhibits the release of proteolytic enzymes in immature and adult parasites, a process
dependant on microtubular functions. The precise molecular mode of action of this fasciolicidal drug remains to be elucidated.

5.2 Pharmacokinetic properties
After oral administration, triclabendazole is rapidly metabolised to its sulphoxide and sulphone metabolites. The sulphoxide is
thought to be the active moiety. In cattle the sulphoxide and sulphone metabolites reached a Cmax of approx. 13 microgram/ml
and 26 microgram/ml at 18 and 48 hours, respectively. The vast majority of orally administered triclabendazole is eliminated in
faeces after 7 days. Urinary excretion is minimal.

6 PHARMACEUTICAL PARTICULARS
6.1 List of excipients
70% non-crystallising sorbitol, (E420)
Methyl hydroxybenzoate, (E218)
Propyl hydroxybenzoate, (E216)
Polysorbate 80 (E433)
Aluminium Magnesium silicate
Microcrystalline cellulose & carmellose sodium, (E460 and E466)
Carmoisine supra (E122)
Simethicone emulsion
Purified water

6.2 Incompatibilities
None known.

6.3 Shelf-life
Shelf life of the veterinary medicinal product as packaged for sale: 18 months

6.4 Special precautions for storage
Do not store above 25°C.
Protect from frost.

6.5 Nature and composition of immediate packaging
Pack sizes:
IL pack contains 0.8L of product,
2.5L pack contains 2.2L of product,
5L pack contains 5L of product
Container: High density polyethylene
Closure: Copolymer polypropylene with tamper evident seal
Cap Liner: Polyfaced Steran Wad
Spout: Polypropylene
Not all pack sizes may be marketed.

6.6 Special precautions for the disposal of unused veterinary medicinal products or waste materials
Any unused veterinary medicinal product or waste materials derived from such veterinary
medicinal products should be disposed of in accordance with local requirements.

7 MARKETING AUTHORISATION HOLDER
Channelle Animal Health Ltd
7 Rodney Street
Liverpool
L1 9HZ
England

8 MARKETING AUTHORISATION NUMBER(S)
VPA 10879/013/002

9 DATE OF THE FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION
20th June 2007

10 DATE OF REVISION OF THE TEXT
29th April 2010
26th November 2010

Delivery

 

Delivery Information

Here at Agridirect we have joined forces with DPD to ensure all packages are delivered promptly and safely to you. We ship to all mainland countries within the EU. Deliveries take place Monday to Friday excluding bank holidays. Once your order has been dispatched from our warehouse you will be notified by email. If there is a delay with your order for any reason you will be contacted immediately. 

Delivery Times
Ireland (ROI & NI)United Kingdom (Mainland Only)EU (Mainland Only)
1-3 Working Days2-4 Working Days4-6 Working Days

Some product have an extended delivery time, this is noted on the products.

Delivery Rates

Delivery Rates
CountryOrders Under €70Orders Over €70
Ireland (ROI & NI)€4.99€0.00
Austria€17.99€13.00
Belgium€14.99€10.00
Czech Republic€17.99€13.00
Denmark€17.99€13.00
Finland€29.99€25.00
France€14.99€10.00
Germany€14.99€10.00
Hungary€21.99€17.00
Italy€27.99€23.00
Luxenburg€14.99€10.00
Netherlands€14.99€10.00
Poland€14.99€13.00
Portugal€29.99€25.00
Slovakia€21.99€17.00
Slovenia€21.99€17.00
Spain€27.99€23.00
Sweden€27.99€23.00
United Kingdom (Mainland Only)€14.99€10.00

 

 

A selection of the products we sell are only licensed for sale within the Republic Of Ireland and can not be shipped outside of the country. These products are noted as only being available within the Republic of Ireland on the individual product pages

There may be an addition charge on certain bulky items. This charge will be clearly marked on an applicable products and will be explained on the checkout page before payment has been made.

 

Returns

Returns Policy

We’re sorry your purchase didn’t work out. But don’t worry; we have a great returns policy to help you out.
 

All purchases can be returned to us within 14 days of delivery and returned goods must be received within 14 days from the date you informed us of the return.
 

Purchases may be opened for inspection but must not be used and must be repackaged securely in the original packaging if you wish to return it.
 

If we discover goods have been used or there has been a loss in value of the goods due to damage to the goods, while in your care or whilst being returned to us, we will reduce the amount refunded, which may amount to the full cost of the product, to cover loss of value of goods.
 

We accept no responsibility for goods damaged or lost while in transit to us. 
 

The cost of the return, including all packaging and freight, lies solely with the consumer.
 

I have received a damaged product from you, what should I do?

First off, if you have received a damaged electrical product from us, do not plug it in. Any electrical products that are plugged in are deemed ‘as used and accepted’ and are not accepted as returns. All damages must be reported to us via phone or email within 24hours of receipt of goods. Please ensure you check your items upon delivery.

How do I begin the returns process?

If you wish to begin the return process, please email us at sales@agridirect.ie and ensure the following information is included in your email. Your name, phone number, Order id, the item you wish to return, reason for return and if the product is damaged we require photos of the product.

Once you have sent us all required information a member of our team will assess your claim and will contact you as soon as possible. Please hold off on returning products until a member of our team has called you to confirm.

 

Packaging

All returns must be the complete product which includes boxes, manuals and accessories that may have been include with the order.

All returns must be packaged appropriately for shipping, we will not accept responsibility for damages or loss which occur during shipping of a return product.
 

Address: Please ship the product to the following address: Agridirect, Drumrahan Retail, Church Street, Ballyconnell, Co Cavan
 

Refunds

Once the returned product has been returned to us and fully inspected a refund will be issued.

Please Note: A typical timeline for a refund to show in your account is up to 10 working days from the date processed, depending on your bank.

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