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This product is only licensed for sale in the Republic Of Ireland

Spirovac is an injectable vaccine that protects beef and dairy cattle against both strains of leptospiia hardjo, Leptospira interrogans serovar hardjo (hardjo Prajitno) and L. borgpetersenii serovar hardjo (hardjo Bovis).

Active Ingredient: Inactivated Leptospira borgpetersenii serovar Hardjo​

Target Species: Cattle

Treats and Controls: Leptospiia hardjo, Leptospira interrogans serovar hardjo (hardjo Prajitno) and L. borgpetersenii serovar hardjo (hardjo Bovis)

Administration Method: Subcutaneous injection (under the skin)

Withdrawal Time: There is no withdrawal time for this product

Dosage for cattle: 2 ml per animal. After the initial vaccination a second dose should be given no less than 4 weeks and no more than 6 weeks after.

Body Weight Dose Volume Doses Per Pack
All Sizes 2ml 25

Always read the label and all enclosed information for Spirovac before administering to animals!

Leptospirosis in cattle

In a study carried out Eoin Lynch MVM it was found that 95% of all beef herds and 76% of all dairy herds have been exposed to leptospirosis infections and if an infection reaches an unvaccinated herd the effects can be severe. He advises that all herd owners should take action in the fight against this infection.

What are the signs of a Leptospirosis infection.

  1. Reduction in milk produced
  2. Abortion which can occur in the late stages of pregnancy
  3. Low conception rates
  4. Weak calves are born
  5. High temperatures in cattle
  6. Flaccid, empty udders
  7. Sudden drop in yield 

How do herds become infected with Leptospirosis?

Leptospirosis is mainly spread through urine, this means all grazing cattle are in danger of becoming infected. The infection can spread where cattle drink from a natural water source such as a river running through land.  Buying in unvaccinated cattle can bring the infection to your herd. The use of a stock bull can spread the infection. Sheep if co-grazing with cattle can spread the infection without showing any signs of infection themselves.

Vaccinating cattle can have increased conception rates.

Another study has shown that vaccinated cattle have a higher conception rate at first service. Herds were divided into two groups, one group was vaccinated and the other was not. The conception rate in vaccinated groups was 51% where the conception rate in the un-vaccinated group was 31 %
This Product is only licensed for sale in the Republic of Ireland

Click here to Download Data Sheet

Summary of Product Characteristics


Each dose (2 ml) of Spirovac contains the following:
Active substances:
Inactivated Leptospira borgpeterseniiserovar Hardjo ≥2RP* * RP = ELISA Relative Potency.

Aluminium hydroxide3.0 to 3.6 mg of aluminium

Formaldehyde<1 mg Thiomersalmax 0.01% (w/v) See Section 6.1 for full list of excipients.

Suspension for injection.
Slightly coloured turbid liquid which might contain a loose sediment.

4.1 Target Species

Cattle from 4 weeks of age.

4.2 Indications for use, specifying the target species
For active immunisation
- of cattle to reduce kidney colonisation and shedding of Leptospira borgpetersenii serovar Hardjo type hardjobovis to the extent that no viable organisms can be detected by culture in the urine of vaccinated animals after challenge; a 3 weeks onset of immunity and 12 months duration of protection have been demonstrated by challenge with Leptospira borgpetersenii serovar Hardjo type hardjobovis.
- of cattle persistently infected with Leptospira borgpetersenii serovar Hardjo type hardjobovis: to reduce urinary shedding of Leptospira borgpetersenii serovar Hardjo type hardjobovis withoutclearance of renal colonisation; this effect appears 4 weeks post vaccination and its duration is unknown.

The epidemiological significance of the reduced shedding has not been demonstrated.
The vaccination may not prevent abortion in cows in which placental infection has already occurred.

4.3 Contraindications

4.4 Special warnings for each target species
Vaccinated cattle may be positive in diagnostic tests for leptospirosis and therefore unacceptable for export to some countries.

4.5 Special precautions for use
Special precautions for use in animals

Special precautions to be taken by the person administering the veterinary medicinal product to animals Even though animals may have been vaccinated, the risk of transmission of leptospirosis from cattle to their handlers, albeit very much reduced, remains.
Appropriate precautions should be maintained at all times and prompt medical advice sought in the event of clinical signs of possible infection.

4.6 Adverse reactions (frequency and seriousness)
A diffuse and oedematous swelling up to 10 cm in diameter, sometimes sensitive to palpation, could occur in up to 40% of animals and can last for up to 66 days after completion of vaccination.
The reaction to subsequent vaccinations and the reaction in pregnant animals (see 4.7) are more marked.
The injection site reaction may be sensitive to palpation the week following vaccination and may persist as a hard nodule for several weeks.

4.7 Use during pregnancy, lactation or lay
Can be used during pregnancy and lactation.
The swelling is more marked in pregnant animals.
A diffuse swelling of up to 22 cm in diameter can occur following second injection.
This effect is more marked for pregnant animals in their third trimester of pregnancy. 

4.8 Interaction with other medicinal products and other forms of interaction
No information is available on the safety and efficacy of this vaccine when used with any other veterinary medicinal product. A decision to use this vaccine before or after any other veterinary medicinal product therefore needs to be made on a case by case basis.

4.9 Amounts to be administered and administration route
Dose: 2 ml Administration:
By subcutaneous injection, preferably in the neck.
Shake the container well before withdrawing the dose.

Basic vaccination scheme: 2 doses of vaccine separated by a 4 to 6 week interval.

Revaccination scheme: A single 2 ml dose on an annual basis.

4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
No adverse drug reactions, other than those listed in Section 4.6, occurred after administration of twice the normal dose.
As part of the natural response following vaccination, and following an overdose of twice the maximum dose of the vaccine, a reactive lymphadenopathy in the local lymph node as well as production of a subcutaneous, granulomatous, inflammatory reaction could be visible under the skin for at least 2 months.
The total duration of this reaction in the underlying tissues is not known.

4.11 Withdrawal period(s)
Zero days.

To stimulate an active immunity against Leptospira borgpeterseniiserovar Hardjo type hardjobovis.
Vaccination induces humoral antibody response and cell-mediated immunity as measured by serology and gamma-interferon production.
A marked, statistically significant difference is also seen in the anamnestic response following a single booster vaccination or infection (challenge) 12 months after primary vaccination.
A strong serological cross-reactivity post vaccination has been demonstrated against Leptospira interrogansserovar Hardjo, a closely related species in the same serovar.
This was sustained for at least 12 months following primary vaccination, and is also seen in the anamnestic response following a single booster vaccination.

A cattle challenge model is not available to document protection.

ATC Vet code:
QI02AB03 (Immunologicals for bovidae, inactivated bacterial vaccines, Leptospira).

6.1 List of excipients

Aluminium hydroxide Thiomersal Formaldehyde Water for injections

6.2 Incompatibilities
Do not mix with any veterinary medicinal product.

6.3 Shelf-life
Shelf life of the veterinary medicinal product as packaged for sale: 2 years.
Shelf life after first opening the immediate packaging: 10 hours.

6.4 Special precautions for storage
Store and transport refrigerated (2°C- 8°C).
Do not freeze.
Protect from light.

6.5 Nature and composition of immediate packaging
5 doses (10ml) or 25 doses (50ml)
Glass type I vials.

Chlorobutyl stopper with aluminium overseal.

Outer Packaging:
Cardboard carton with package insert leaflet.

Pack sizes:
5 or 25 doses (10 or 50ml).

Not all pack sizes may be marketed.

6.6 Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Zoetis Belgium S.A.
2nd Floor,
Building 10
Cherrywood Business Park
Co Dublin


Date of first authorisation: 14th March 2008
Date of last renewal: 28th October 2011

September 201

 Cattle Injectables
Injectables should be given according to the manufacturer’s instructions at the recommended injection site.
• Always use a clean, sterile syringe and needle. If using a multiple injection gun, ensure the needle is disinfected between injections, e.g. with an automatic sterilisation system.
• If the site to be injected is dirty, clean the skin and swab with an alcohol-impregnated wipe or cotton wool.
• Before injecting, check the expiry date and read the instructions of the product to be used. Some products need to be shaken before use.
• Use the correct-sized needle according to the size of the animal and site of injection.
• Ensure the animal is adequately restrained before attempting the injection.
• Take care to ensure it is given subcutaneously and not intramuscularly. Raise a fold of skin at the injection site (mainly neck but some are ear) recommended by the product manufacturer and inject carefully into the space created.
• If a large dose is to be delivered, it may be advisable to split the dose between two injection sites. After the injection, briefly massage the site to improve the dispersal of the injected material.
• Dispose of the needle and syringe in appropriate clinical waste and sharps containers.


Delivery Information

Delivery Service

Here at Agridirect we have joined forces with DPD to ensure all packages are delivered promptly and safely to you. We ship to all mainland countries within the EU. Deliveries take place Monday to Friday excluding bank holidays. Once your order has been dispatched from our warehouse you will be notified by email. If there is a delay with your order for any reason you will be contacted immediately. 

Due to Brexit we are temporarily unable to ship to the UK. Shipping to Northern Ireland will remain in place.

Delivery Times
Ireland (ROI & NI) EU (Mainland Only)
2-4 Working Days 4-6 Working Days

Some products have an extended delivery time, this is noted on the products.

Delivery Rates

Country Orders Under €129 Orders Over €129
Ireland (ROI & NI) €7.99 €0.00
Austria €24.99 €17.00
Belgium €21.99 €14.00
Czech Republic €24.99 €17.00
Denmark €24.99 €17.00
Finland €36.99 €29.00
France €21.99 €14.00
Germany €21.99 €14.00
Hungary €28.99 €21.00
Italy €34.99 €23.00
Luxenburg €21.99 €14.00
Netherlands €21.99 €14.00
Poland €21.99 €17.00
Portugal €36.99 €29.00
Slovakia €28.99 €21.00
Slovenia €28.99 €21.00
Spain €34.99 €27.00
Sweden €34.99 €27.00


A selection of the products we sell are only licensed for sale within the Republic Of Ireland and can not be shipped outside of the country. These products are noted as only being available within the Republic of Ireland on the individual product pages.

There may be an addition charge on certain bulky items. This charge will be clearly marked on an applicable products and will be explained on the checkout page before payment has been made.

Agridirect Returns Policy

We’re sorry your purchase didn’t work out. But don’t worry; we have a great returns policy to help you out.

All purchases can be returned to us within 14 days of delivery and returned goods must be received within 14 days from the date you informed us of the return.

Purchases may be opened for inspection but must not be used and must be repackaged securely in the original packaging if you wish to return it.

If we discover goods have been used or there has been a loss in value of the goods due to damage to the goods, while in your care or whilst being returned to us, we will reduce the amount refunded, which may amount to the full cost of the product, to cover loss of value of goods.

All returns should be complete which includes boxes, manuals and accessories that may have been included with the order.

All returns must be packaged appropriately for shipping, we will not accept responsibility for damages or loss which occur during shipping of a return product.

We accept no responsibility for goods damaged or lost while in transit to us. 

How do I return a product?

We have partnered with DPD to make your returns process easy and secure. simply follow the steps below and bring your package to an official DPD pickup point.

1) All returns must be accompanied with a fully filled out returns form which can be downloaded here.

2) To print off your return label click here or visit and follow the on-screen instructions. Make sure and use your order number as your reference.

  • Select “Continue as Guest”
  • Select “Agridirect” from the drop-down menu
  • Select your reason for returning
  • Select the size of the package you wish to return
  • Accept DPD’s terms and conditions
  • Fill in your payment details
  • Fill in your own details
  • Follow the instructions to print off your label

3) Bring your package to a DPD pickup point. To find your nearest drop off point here.

Once the returned product has been received into our warehouse and been fully inspected a refund will be issued.

If you choose not to use the DPD returns service we recommend that you use a method that can be tracked.

For the return of bulk products please contact us at

I have received a damaged product from you, what should I do?

First off, if you have received a damaged electrical product from us, do not plug it in. Any electrical products that are plugged in are deemed ‘as used and accepted’ and are not accepted as returns. All damages must be reported to us via phone or email within 24hours of receipt of goods. Please ensure you check your items upon delivery.

How do I begin the returns process?

If you wish to begin the return process, please email us at and ensure the following information is included in your email. Your name, phone number, Order id, the item you wish to return, reason for return and if the product is damaged we require photos of the product.

Once you have sent us all required information a member of our team will assess your claim and will contact you as soon as possible. Please hold off on returning products until a member of our team has called you to confirm.


Once the returned product has been returned to us and fully inspected a refund will be issued.

Please Note: A typical timeline for a refund to show in your account is up to 10 working days from the date processed, depending on your bank.



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