Moxodex LA 100 mg/ml (Moxidectin)

Moxodex LA 100 mg/ml Solution for Injection for Cattle is a long-acting injectable parasiticide containing moxidectin 100 mg/ml. It is used for the treatment and prevention of mixed infestations of gastrointestinal roundworms, lungworms and certain external parasites in cattle weighing between 100 kg and 500 kg.

With a single injection, Moxodex LA provides persistent protection against specified parasites for up to 150 days, depending on the parasite species. Treatment immediately before turnout can help reduce the build-up of infective larvae on pasture and reduce the need for repeated handling of cattle.

Product Information

Withdrawal Periods

Important: The withdrawal period is based solely on a single injection at the specified ear injection site. Observe the 108-day meat and offal withdrawal period following treatment.

What Does Moxodex LA Treat?

Moxodex LA is used for the treatment and prevention of mixed infestations of susceptible internal and external parasites in cattle weighing between 100 kg and 500 kg.

Cattle - Parasites Treated and Controlled

• Gastrointestinal Roundworms: Haemonchus placei, Haemonchus contortus, Ostertagia ostertagi, Trichostrongylus axei, Trichostrongylus colubriformis, Nematodirus helvetianus (adults only), Nematodirus spathiger, Cooperia surnabada, Cooperia oncophora, Cooperia pectinata, Cooperia punctata, Oesophagostomum radiatum, Bunostomum phlebotomum (adults only), Chabertia ovina (adults only) and Trichuris species (adults only).
• Inhibited Larvae: Effective against inhibited larvae of Ostertagia ostertagi.
• Lungworms: Dictyocaulus viviparus (adult and immature stages).
• Warble Grubs: Migrating larvae of Hypoderma bovis and Hypoderma lineatum.
• Sucking Lice: Linognathus vituli, Haematopinus eurysternus and Solenopotes capillatus.
• Biting Lice: Aids in the control of Bovicola bovis.
• Mange Mites: Sarcoptes scabiei and Psoroptes ovis. Aids in the control of Chorioptes bovis.

Key Features of Moxodex LA

• Long-Acting Parasite Control: Provides persistent protection against specified internal and external parasites for up to 150 days.
• Single Injection: One treatment can reduce repeated handling and treatment requirements against the parasites covered.
• Turnout Treatment: Suitable for administration immediately before eligible cattle are turned out to pasture.
• Lungworm Protection: Provides 120 days of protection against Dictyocaulus viviparus.
• Gastrointestinal Worm Protection: Provides 90-150 days of protection against specified gastrointestinal roundworms.
• Lice Protection: Provides 133 days of protection against Linognathus vituli.
• Reduced Pasture Contamination: Helps reduce the build-up of infective larvae associated with specified parasites on pasture.
• Use During Pregnancy: May be used during pregnancy, subject to the stated milk restrictions and contraindications.
• Group Dosing: Cattle of similar bodyweight can be grouped and dosed according to the heaviest animal in each group.

Moxodex LA Dosage for Cattle

Recommended Dose: 0.5 ml per 50 kg bodyweight, equivalent to 1 mg moxidectin per kg.

This dose is administered as a single subcutaneous injection into the loose tissue on the dorsal (hairy) surface of the ear.

Important: Do not use in cattle weighing less than 100 kg or more than 500 kg.

Cattle - Dose and Bottle Coverage

Bottle Coverage: The 50 ml and 250 ml columns show the number of complete doses available at the stated bodyweight, calculated from the dose volume and rounded down to whole doses. Figures assume no product wastage.

Persistent Protection Periods

Moxodex LA provides protection against infection or reinfection with the following parasites for the specified periods.

Important: Persistent protection periods have not been established for parasite species other than those listed above. Reinfection with other parasites may occur before the stated protection periods have ended.

Administration Instructions

• Ear Injection Only: Administer by subcutaneous injection into the loose tissue on the dorsal (hairy) surface of the ear. Do not use any other injection site or route.
• Shake Before Use: Shake the vial well before administering Moxodex LA.
• Accurate Bodyweight: Determine bodyweight as accurately as possible to calculate the correct dose.
• Correct Equipment: Use an 18-gauge, 25-40 mm hypodermic needle.
• Injection Site Preparation: Clean the dorsal surface of the ear with antiseptic and allow it to air dry.
• Correct Injection Position: Insert the needle approximately 3-3.5 cm distal to the edge of the auricular cartilage, directing it towards the base of the ear.
• Avoid Blood Vessels: Take care to avoid arteries and veins. Gently aspirate before injecting to confirm that the needle is not in a blood vessel.
• After Injection: Apply pressure at the insertion point while withdrawing the needle to help seal the opening.
• Equipment Calibration: Check dosing equipment before treatment to reduce the risk of underdosing or overdosing.
• Aseptic Technique: Use strict aseptic technique to reduce the risk of injection-site abscesses.
• Do Not Mix: Do not mix Moxodex LA with other veterinary medicinal products.

Important Safety Information

• Target Species: For cattle only, weighing between 100 kg and 500 kg.
• Hypersensitivity: Do not use in animals with known hypersensitivity to moxidectin or any of the excipients.
• Injection Route: Never administer by intravascular injection. Accidental injection into a blood vessel may cause ataxia, paralysis, convulsions, collapse or death.
• Pregnancy: May be used during pregnancy, subject to the specified restrictions.
• Milk Restriction: Not permitted for use in lactating animals producing milk for human consumption or industrial purposes, or within 80 days of expected calving.
• Anthelmintic Resistance: Unnecessary treatment, repeated use and underdosing can increase the risk of parasite resistance. Discuss treatment programmes with your veterinary surgeon.
• Warble Grub Treatment: Consult a veterinary surgeon regarding the correct treatment timing to reduce the risk of reactions associated with dying Hypoderma larvae.
• Adverse Reactions: Injection-site swelling, depression and ataxia have been reported rarely. Injection-site abscesses have been reported very rarely.
• Skin and Eye Contact: Avoid direct contact with skin and eyes. Wash exposed skin with soap and water and rinse eyes thoroughly with water if accidental contact occurs.
• After Handling: Wash hands thoroughly after use. Do not eat, drink or smoke while handling the product.
• Accidental Self-Injection: Seek immediate medical advice and show the product label or package leaflet.
• Environmental Protection: Moxidectin is toxic to aquatic organisms and may temporarily affect dung-feeding organisms.
• Watercourse Restriction: Treated cattle should not have access to watercourses for 10 days after treatment.

How Cattle Become Infected with Parasites

Cattle can become infected with gastrointestinal roundworms and lungworms while grazing pasture contaminated with infective parasite larvae. Infection risk can vary depending on grazing conditions, pasture history, weather and previous parasite-control measures.

External parasites such as lice and mange mites may spread through contact between animals, while warble flies can expose cattle to Hypoderma larvae during the fly season.

Parasite burdens can affect cattle health, growth and productivity. Farmers should consider grazing history, parasite monitoring and veterinary advice when planning parasite-control programmes.

Important: Moxodex LA provides persistent protection only against the specific parasites and for the durations stated in the product data sheet. It should not be assumed to provide equal protection against every parasite throughout the grazing season.

Storage and Shelf Life

• Shelf Life: 2 years when packaged for sale.
• After Opening: Use within 28 days of first opening.
• Storage: Do not store above 25°C.
• Light Protection: Keep the vial in its outer carton to protect it from light.
• Pack Sizes: Available in 50 ml and 250 ml vials.
• 50 ml Vial: Do not puncture the stopper more than 20 times.
• 250 ml Vial: Use automatic syringe equipment and do not puncture the stopper more than five times.
• Disposal: Do not contaminate waterways with the product or used containers. Dispose of unused veterinary medicines and waste through appropriate take-back schemes.
• Marketing Authorisation Holder: Chanelle Pharmaceuticals Manufacturing Limited.
• Irish Marketing Authorisation Number: VPA10987/171/001.

Important: Always read the product label and all enclosed information for Moxodex LA 100 mg/ml Solution for Injection for Cattle before administering to animals. Follow veterinary advice and observe the specified withdrawal periods.