Doramax 10 mg/ml Injection (Doramectin)

Doramax 10 mg/ml Solution for Injection is a broad-spectrum antiparasitic treatment for cattle, sheep and pigs. Containing 10mg/ml doramectin, it treats a range of internal and external parasites, including gastrointestinal roundworms, lungworms, mange mites and other species-specific parasites.

Doramax provides persistent activity against certain parasites following treatment, helping farmers manage parasite challenges in their herds and flocks. It is administered by subcutaneous injection in cattle and intramuscular injection in sheep and pigs.

Product Information

Withdrawal Periods

Important: Always observe the specified meat and offal withdrawal periods and milk restrictions before treating livestock.

What Does Doramax Injection Treat?

Cattle - Parasites Treated and Controlled

• Gastrointestinal Roundworms: Ostertagia ostertagi (including inhibited larvae), Ostertagia lyrata (adults), Haemonchus placei, Trichostrongylus axei, Trichostrongylus colubriformis, Cooperia oncophora, Cooperia pectinata (adults), Cooperia punctata, Cooperia surnabada, Nematodirus spathiger (adults), Bunostomum phlebotomum (adults), Strongyloides papillosus (adults), Oesophagostomum radiatum and Trichuris species (adults).
• Lungworms: Dictyocaulus viviparus (adults and fourth-stage larvae).
• Eyeworms: Thelazia species (adults).
• Warbles: Hypoderma bovis and Hypoderma lineatum (parasitic stages).
• Sucking Lice: Haematopinus eurysternus, Linognathus vituli and Solenopotes capillatus.
• Mange Mites: Psoroptes bovis and Sarcoptes scabiei.
• Additional Control: May aid in the treatment of Nematodirus helvetianus, Damalinia bovis biting lice, Ixodes ricinus ticks and Chorioptes bovis mange mites.

Sheep - Parasites Treated and Controlled

• Gastrointestinal Roundworms: Bunostomum trigonocephalum (adults), Chabertia ovina, Cooperia curticei (fourth-stage larvae), Cooperia oncophora, Gaigeria pachyscelis, Haemonchus contortus, Nematodirus battus (fourth-stage larvae), Nematodirus filicollis (adults), Nematodirus spathiger, Ostertagia (Teladorsagia) circumcincta, Ostertagia (Teladorsagia) trifurcata (adults), Oesophagostomum venulosum (adults), Oesophagostomum columbianum, Strongyloides papillosus, Trichostrongylus axei, Trichostrongylus colubriformis, Trichostrongylus vitrinus and Trichuris species (adults).
• Lungworms: Cystocaulus ocreatus (adults), Dictyocaulus filaria, Muellerius capillaris (adults), Neostrongylus linearis (adults) and Protostrongylus rufescens (adults).
• Nasal Bots: Oestrus ovis (first, second and third instar larvae).
• Sheep Scab: Psoroptes ovis, using the specified higher dose.

Pigs - Parasites Treated and Controlled

• Gastrointestinal Roundworms: Hyostrongylus rubidus, Ascaris suum, Strongyloides ransomi (adults), Oesophagostomum dentatum and Oesophagostomum quadrispinulatum.
• Lungworms: Metastrongylus species (adults).
• Kidney Worms: Stephanurus dentatus (adults).
• Sucking Lice: Haematopinus suis.
• Mange Mites: Sarcoptes scabiei.

Doramax provides protection against infection or reinfection with Sarcoptes scabiei in pigs for 18 days following treatment.

Key Features of Doramax Injection

• Broad-Spectrum Treatment: Treats a range of internal and external parasites in cattle, sheep and pigs.
• Persistent Activity: Provides continued protection against certain specified parasites following administration.
• Sheep Scab Treatment: Indicated for treatment of Psoroptes ovis using the specified higher dose.
• Pig Mange Control: Protects against Sarcoptes scabiei infection or reinfection for 18 days.
• Breeding Animals: May be used in pregnant cows and ewes and is indicated for breeding and lactating sows and breeding boars, subject to milk restrictions.
• Species-Specific Dosing: The correct dosage and injection route depend on the species and treatment indication.

Doramax Injection Dosage for Cattle

Recommended Dose: 1ml per 50kg bodyweight, equivalent to 200 micrograms doramectin per kg bodyweight.

Administration: A single subcutaneous injection in the neck region.

Maximum Injection Volume: 5ml per injection site. Divide larger doses between multiple injection sites.

Cattle - Dose and Bottle Coverage

Bottle Coverage: Figures show the number of complete doses available at each bodyweight, rounded down to whole doses and assuming no product wastage.

Doramax Injection Dosage for Sheep

Sheep require different doses depending on the parasite being treated. All sheep doses are administered by intramuscular injection.

Maximum Injection Volume: 1.5ml per injection site.

General Sheep Parasite Treatment - 1ml per 50kg

For the gastrointestinal roundworms and nasal bots specified in the data sheet, the recommended dose is 1ml per 50kg bodyweight, equivalent to 200 micrograms doramectin per kg.

Sheep Scab Treatment - 1ml per 33kg

For treatment of clinical signs of Psoroptes ovis (sheep scab) and elimination of living mites, administer 1ml per 33kg bodyweight, equivalent to approximately 300 micrograms doramectin per kg, by intramuscular injection in the neck.

Bottle Coverage: Figures show complete doses calculated from the listed dose volumes, rounded down to whole doses and assuming no wastage.

Important: Sheep scab requires the higher dose of 1ml per 33kg. Divide doses exceeding 1.5ml between injection sites.

Doramax Injection Dosage for Pigs

Recommended Dose: 1ml per 33kg bodyweight, equivalent to approximately 300 micrograms doramectin per kg.

Administration: A single intramuscular treatment.

Maximum Injection Volume: 2.5ml per injection site. Divide larger doses between multiple injection sites.

Pigs - Dose and Bottle Coverage

Bottle Coverage: Figures show complete doses at the listed bodyweights, rounded down to whole doses and assuming no wastage. Divide doses exceeding 2.5ml between injection sites.

Piglets Weighing 16kg or Less

For piglets weighing 16kg or less, follow the specific dosage table provided in the official data sheet.

Important: For piglets weighing 16kg or less, use a 1ml disposable syringe graduated in increments of 0.1ml or less. The data sheet does not specify a dose for exactly 4kg; seek veterinary clarification rather than assuming a dose.

Persistent Activity in Cattle

Following treatment, Doramax provides protection against reinfection with the specific cattle parasites listed below. These protection periods do not apply to every parasite treated by the product.

When Should I Treat Livestock with Doramax?

The most suitable treatment time depends on the animal species, parasite risk, grazing history and individual farm management.

Common times to review parasite-control requirements with your veterinary surgeon include:

• At Turnout: Assessing gastrointestinal roundworm and lungworm risk when cattle begin grazing.
• During the Grazing Season: Monitoring parasite exposure and animal performance to determine whether treatment is needed.
• At Housing: Reviewing internal and external parasite burdens as part of winter management.
• Sheep Scab Outbreaks: Treating affected sheep and managing contact between infected and uninfected groups.
• Pig Herd Management: Assessing mange, lice and internal parasite risks as part of a veterinary-led herd health programme.

Important: These are general parasite-management considerations, not fixed treatment dates specified in the data sheet. Treatment should be based on parasite risk, local resistance patterns and veterinary advice.

Sheep Scab Treatment and Flock Management

When treating sheep scab caused by Psoroptes ovis, Doramax must be administered at the specified 1ml per 33kg intramuscular dose.

The data sheet also advises appropriate biosecurity measures to prevent reinfestation:

• Ensure all sheep that have been in contact with infested sheep are treated.
• Prevent contact between treated and untreated sheep where there is a risk of reinfestation.
• Follow veterinary advice and appropriate flock-management practices.

Administration Instructions

• Cattle: Administer by subcutaneous injection in the neck region. Maximum 5ml per injection site.
• Sheep: Administer by intramuscular injection. Maximum 1.5ml per injection site.
• Pigs: Administer by intramuscular injection. Maximum 2.5ml per injection site.
• Accurate Bodyweight: Determine bodyweight as accurately as possible before treatment.
• Dosing Equipment: Check the accuracy of dosing equipment.
• Group Treatment: Group animals according to bodyweight to reduce the risk of underdosing or overdosing.
• Hygiene: Use sterile equipment, follow aseptic procedures and swab the vial septum before removing each dose.
• Automatic Equipment: For group treatment, use a suitable automatic dosing device and vented draw-off apparatus.
• Vial Punctures: When using an automatic injection device, do not puncture the vial stopper more than once.
• Manual Withdrawal: Do not puncture the vial stopper more than 10 times for 50ml packs or 25 times for 250ml and 500ml packs.
• Individual Pigs: Seek veterinary advice on suitable needle and syringe sizes.
• Small Piglets: For piglets weighing 16kg or less, use a 1ml disposable syringe graduated in increments of 0.1ml or less.
• Warble Treatment: The data sheet recommends treatment at the end of warble fly activity and before larvae reach their resting sites, to reduce the risk of secondary reactions associated with dying larvae.

Important Safety Information

• Target Species: For cattle, sheep and pigs only.
• Contraindications: Do not use in dogs or in animals with known hypersensitivity to doramectin or any excipients.
• Milk Restrictions: Not authorised for use in cattle or sheep producing milk for human consumption. Observe the additional restrictions for pregnant dairy animals.
• Pregnancy and Breeding: May be used in pregnant cows and ewes, subject to milk restrictions. The product is indicated for breeding and lactating sows and breeding boars.
• Anthelmintic Resistance: Frequent repeated use of the same anthelmintic class and underdosing can increase the risk of resistance.
• Resistance Monitoring: Resistance to avermectins and related antiparasitic medicines has been reported in certain parasite populations. Seek veterinary advice on appropriate treatment programmes.
• Non-Target Species: Severe reactions, including fatalities, may occur in certain dog breeds and in turtles or tortoises.
• Adverse Events: None known according to the supplied data sheet.
• Personal Protection: Do not smoke or eat while handling the product. Wash hands after use and avoid accidental self-injection. Seek medical attention if concerning symptoms occur following accidental self-injection.
• Environmental Warning: Doramectin is very toxic to aquatic organisms and dung fauna and may accumulate in sediments.
• Water Protection: Keep treated cattle away from water bodies for two to five weeks after treatment to reduce environmental risk.
• Compatibility: Do not mix with other veterinary medicinal products.

What Are the Effects of Parasites on Livestock?

Internal and external parasite infections can affect livestock health, growth and overall performance. Depending on the parasite involved and severity of infection, possible effects include:

• Reduced Growth: Parasite burdens may contribute to poor liveweight gain and reduced body condition.
• Reduced Productivity: Infected animals may experience poorer performance and reduced feed efficiency.
• Respiratory Problems: Lungworm infections can cause coughing and breathing difficulties.
• Skin Irritation: Lice and mange mites can cause itching, discomfort and skin damage.
• Animal Welfare: Heavy parasite burdens can affect overall animal health and wellbeing.

Effective parasite management should be based on the parasites present, animal age, grazing history, local resistance patterns and veterinary advice.

Storage and Shelf Life

• Shelf Life: 30 months when packaged for sale.
• After Opening: Use within 28 days of first opening.
• Storage: Store in the original package to protect from light.
• Packaging: Type II amber glass multidose vials with chlorobutyl rubber stoppers and aluminium caps.
• Pack Sizes: 50ml, 250ml and 500ml. Not all pack sizes may be marketed.
• Disposal: Do not dispose of the product via wastewater or household waste. Use appropriate veterinary medicine take-back schemes and follow local disposal requirements.
• Marketing Authorisation Holder: Chanelle Pharmaceuticals Manufacturing Ltd.
• Irish Marketing Authorisation Number: VPA10987/170/001.
• Legal Classification: Veterinary medicinal product subject to prescription.

Important: Always read the product label and all enclosed information for Doramax 10 mg/ml Solution for Injection before administering to animals. Follow veterinary advice and observe the specified withdrawal periods.