Taktic

Taktic 12.5% w/v is used for the treatment and control lice, ticks, mites, mange and keds in sheep, cattle and pigs. It is used as a spray for cattle and pigs or can be used as a dip or as a spray for sheep. The active ingredient in Taktic 12.5% is amitraz and when used as part of a regular cleaning routine will keep your animals free from external parasites such as lice and ticks. 

Active Ingredient: amitraz

Target Species: Cattle, sheep, pigs

Treats and Controls: lice, ticks, mites, mange, keds and sheep scab

Administration Method: Spray or dip

Withdrawal Time: 4 days for cattle intended for meat and offal, 4 days for cattle producing milk for human consumption. 24 days for sheep intended for meat and offal, not suitable for sheep producing milk for human consumption. 1 day for pigs intended for meat or offal.

Dosing for Cattle : Mix at the rate of 20 ml Taktic with every 10 litres of water. Prepare spray on the day of treatment, using clean water. Spray each animal depending on its live weight with 5 - 10 litres. Spray the whole body of the animal until it is thoroughly wet. In severe cases of mange and lice repeat the treatment after 7 - 10 days. In order to maintain the herd free from mange and lice, it is advisable to carry out regular routine treatments. Treat all animals in a group whether visibly affected or not. For control of ticks, cattle should be treated every 9 - 10 days during the period of risk.

Dosing for Pigs : Mix at the rate of 40 ml Taktic with every 10 litres of water. Prepare spray on the day of treatment, using clean water. Remove feed from pen and cover drinking bowls. Remove bedding and clean out pens. Treat all animals in a group at the same time, whether visibly affected or not. Use sufficient spray to soak animals thoroughly, paying particular attention to ears, groin and between the forelegs. Scabs need not be removed prior to treatment. During treatment spray walls, floors and fittings in the pen.

Dosing for Sheep : For ticks, lice, keds and mange mites including sheep scab, all sheep at risk should be treated. A single treatment will kill ticks and provide protection against reinfestation for up to 6 weeks. For lice and keds treatment should be repeated after 14 days and thereafter, if signs of reinfestation appear. Taktic is approved for control of sheep scab in a single dipping. Taktic has no strong odour - does not cause mis-mothering.

Always read the label and all enclosed information for Taktic 12.5% before administering to animals!

Advantages of using Taktic

Easy to use: Taktic 12.5% is easy to use as a dip or a spray which makes the treatment of livestock quick and easy saving the farmer time and money.

Summary of Product Characteristics

1 NAME OF THE VETERINARY MEDICINAL PRODUCT
Taktic 12.5% w/v Concentrate for dip emulsion

2 QUALITATIVE AND QUANTITATIVE COMPOSITION
Active Substance
Amitraz 125 g/litre
For a full list of excipients see section 6.1.

3 PHARMACEUTICAL FORM
Concentrate for dip emulsion

4 CLINICAL PARTICULARS
4.1 Target Species
Pigs, cattle and sheep.

4.2 Indications for use, specifying the target species
Pigs: For the treatment and control of sarcoptic mange and lice.
Cattle: For the treatment and control of ticks, mange mites and lice.
Sheep: For the treatment and control of ticks and mange mites and for the treatment of lice and keds.

4.3 Contraindications
Do not use in animals with known hypersensitivity to the active ingredient.
Do not use in sheep producing milk for human consumption.

4.4 Special warnings for each target species
Do not dip tired or thirsty animals.

4.5 Special precautions for use
Special precautions for use in animals
None.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
When handling concentrate or when spraying: Wear water proof overalls, rubber gloves (neoprene or nitrile of
minimum thickness 0.5 mm), rubber boots and face shield when opening containers, diluting or spraying animals with
diluted product or when washing out empty containers.
When handling dip concentrate or working with diluted dip and freshly dipped sheep: Wear rubber gloves (heavy-duty
gauntlet style nitrile at least 300 mm in length and 0.5 mm thick), rubber boots, waterproof trousers or leggings and
coat or bib-apron and a face shield when handling the concentrate. Dipping should be carried out in a well ventilated
area, preferably outdoors.
When using, do not eat, drink or smoke. Do not breathe spray mist. Avoid all contact with mouth, skin and eyes.
Wash concentrate or splashes of diluted spray from skin or eyes immediately. Wash all protective clothing thoroughly
after use, especially the inside’s of gloves. Wash hands and exposed skin before eating, drinking or smoking after
work.
GUIDE TO DOCTOR: Amitraz is NOT an organophosphorus compound. If poisoning is suspected, treatment should
be symptomatic and supportive, paying particular attention to monitoring of respiratory and cardiac function.
However, recovery is normally spontaneous. Do NOT use Atropine. Do NOT induce vomiting.

4.6 Adverse reactions (frequency and seriousness)
None at the recommended treatment rates.

4.7 Use during pregnancy, lactation or lay
This product may be used during pregnancy and lactation.
Do not use in sheep producing milk for human consumption.

4.8 Interaction with other medicinal products and other forms of interaction
None.

4.9 Amounts to be administered and administration route
As a spray for pigs and cattle or by spray or dip treatment for sheep.
Pigs: Mix at the rate of 40 ml ‘Taktic’ with every 10 litres of water. Prepare spray on the day of treatment, using
clean water. Remove feed from pen and cover drinking bowls. Remove bedding and clean out pens. Treat all animals
in a group at the same time, whether visibly affected or not. Use sufficient spray to soak animals thoroughly, paying
particular attention to ears, groin and between the forelegs. Scabs need not be removed prior to treatment. During
treatment spray walls, floors and fittings in the pen.
Recommended Control Programme
Initially treat the whole herd with Taktic. Repeat after 7 - 10 days. Make routine prophylactic treatment as follows:
Working Boars: Treat routinely every 2 - 3 months
Sows and Gilts: Treat as they enter farrowing quarters
Young Pigs: Treat after weaning or before moving to fattening houses
New additions to herd: Isolate and treat before mixing with other pigs
Buildings: To disinfect empty buildings, a single treatment of 80 ml Taktic with 10 litres water can be used
Cattle: Mix at the rate of 20 ml Taktic with every 10 litres of water. Prepare spray on the day of treatment, using clean
water. Spray each animal depending on its live weight with 5 - 10 litres. Spray the whole body of the animal until it is
thoroughly wet. In severe cases of mange and lice repeat the treatment after 7 - 10 days. In order to maintain the herd
free from mange and lice, it is advisable to carry out regular routine treatments. Treat all animals in a group whether
visibly affected or not. For control of ticks, cattle should be treated every 9 - 10 days during the period of risk.
Sheep: For ticks, lice, keds and mange mites including sheep scab, all sheep at risk should be treated. A single
treatment will kill ticks and provide protection against reinfestation for up to 6 weeks. For lice and keds treatments
should be repeated after 14 days and thereafter, if signs of reinfestation appear. Taktic is approved for control of sheep
scab in a single dipping. Taktic has no strong odour - does not cause mis-mothering.
INITIAL CONCENTRATION: Mix at the rate of 1 litre Taktic with every 250 litres of water. Topping up: Mix at the
rate of 1.5 litres Taktic with every 250 litres of water added. Do not allow the volume in the dip to drop by more than
10 % of the original volume before topping up.
METHOD: Prepare the dip on the day of dipping. Fill the bath with clean water. Add
the required amount of Taktic directly into the water in the bath and mix thoroughly by stirring well. Dip wash must be
used on the day of preparation and must be discarded at the end of the day’s dipping.
WHEN TO DIP: Adult sheep should be dipped immediately before ticks are expected to appear. Growing sheep
should be dipped before being introduced to the tick infested land. Lambs can be safely dipped from 3 - 4 days of age
and should be re-dipped after 3 to 4 weeks as the short fleece cannot hold sufficient dip to give prolonged protection.
Allow sheep to rest and satisfy thirst before dipping. Sheep should be held in the dip wash for 1 minute immersing the
head at least once.

4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
In the unlikely event of accidental overdose, sedation may be observed. Natural recovery can normally be expected
without clinical intervention but if necessary, supportive therapy should be maintained until symptoms subside.

4.11Withdrawal Period(s)
Cattle
Meat and offal: 4 days
Milk: 4 days
Pig
Meat and offal: 1 day
Sheep
Meat and offal: 24 days
Milk: Not to be used for human consumption

5 PHARMACOLOGICAL or IMMUNOLOGICAL PROPERTIES
Pharmacotherapeutic group: Ectoparasiticides for topical use, amitraz.
ATCvet code: QP53AD01

5.1 Pharmacodynamic properties
Amitraz is a parasiticide belonging to the formamidine group of insecticides. The principle mode of action is
interaction with octopamine receptors in the central nervous system (CNS) of ectoparasites which induces increased
neuronal activity, abnormal behaviour, detachment and death.
Amitraz has a variety of pharmacodynamic activities which are believed to contribute both to its biological efficacy and
to the clinical signs of toxicity.
Amitraz is a contact insecticide/acaricide with extended residual activity, functioning as an agonist at octopamine
receptors in the nerve synapses. This produces increased nervous activity leading to rapid detachment of parasites and
their eventual mortality. This novel mode of action differs from other established insecticides e.g. organophosphates,
carbamates and synthetic pyrethroids.
In mammals, the following activities have been reported:
i. Alpha-2-adrenoreceptor agonist:
This is the main activity responsible for most clinical signs.
ii. Weak inhibitor of serotonin receptors
iii. Weak H1 receptor antagonist
iv. Mono-amine oxidase inhibitor in vitro but not apparently in vivo
Clinical symptoms of toxicity include:
i. Signs of CNS depression e.g. drowsiness
ii. Reduced body temperature
iii. Reduced heart rate and blood pressure
iv. Increased blood sugar levels (alpha-2-adrenergic agonists are known to reduce insulin release, e.g. clonidine)
v. Delayed gastro-intestinal transit.

5.2 Pharmacokinetic properties
Dermal absorption of amitraz is relatively slow and achieves peak blood levels 24-72 hours after dosing. Less than 10
% of the total applied dose was absorbed during the first 12 hours of a study on pigs.
Metabolism appears to follow the same route in all mammals observed to date.
Initial hydrolysis of amitraz is to N-(2,4-dimethylphenyl)-N’-methylformamidine (BTS 27271) and 2,4-
dimethylformanilide (BTS 27919). The main end-products of metabolism are excreted predominantly in the urine and
consist of 2-methyl-4-carboxyformanilide (BTS 39098), 4-acetamido-3-methylbenzoic acid (FBC 31158), their
respective conjugates and conjugates of 4-amino-3-methylbenzoic acid (BTS 28369).
All these products may be converted to BTS 28369 by acid hydrolysis during extraction and processing. Excretion has
been rapid following oral dosing in all species studied, with urine as the major route, accounting for 65 - 84 % of the
dose (55 - 76 % in the first 24 hours).

6 PHARMACEUTICAL PARTICULARS

6.1 List of excipients
Tetra isopropyldiphenylcarbodiimide (Staboxol 1)
Nonyl phenol-ethylene oxide condensate (Ethylan KEO)
Solvesso 200

6.2 Incompatibilities
None known.

6.3 Shelf-life
Shelf-life of the veterinary medicinal product as packaged for sale: 2 years.
In-use shelf-life: Make up wash immediately before use. Any remaining product should be discarded.

6.4 Special precautions for storage
Do not store above 25oC.
Protect from frost.
Store in the original container tightly closed.

6.5 Nature and composition of immediate packaging
1 litre and 5 litre co-extruded PA/HDPE bottle with polyethylene screw cap. Not all pack sizes may be marketed.

6.6 Special precautions for the disposal of unused veterinary medicinal products or waste materials
WARNING
Harmful to fish. Do not contaminate ponds, waterways or ditches. Empty containers thoroughly and dispose of safely.
Do not re-use empty containers.
Used dip should either be stored in a suitable holding tank prior to disposal by a reputable specialist contractor or it
may be spread onto suitable land where there is no risk of pollution to ground or surface water.
Unused product or waste material should be disposed of in accordance with current practice for pharmaceutical waste
under national waste disposal regulations.

7 MARKETING AUTHORISATION HOLDER
Intervet Ireland Limited,
Magna Drive
Magna Business Park
Citywest Road
Dublin 24

8 MARKETING AUTHORISATION NUMBER(S)
VPA 10996/125/001

9 DATE OF THE FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION
30th september 2009
 

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